TH1895B - The process of preparing PGRF (Physical Grain-Based Fertilizer) for mammals. - Google Patents

Abstract

has shown the synthesis process of PGRF, which is a strong substance To stimulate human release of pituitary GH, the formula is as follows (chemical formula) This peptide or its parts containing Biological activity or its analogues known to Replaces and/or fills well and salts of the aforementioned substances. The above are non-toxic and may be administered to mammals, mammals as well as humans and may be used for the diagnosis of peptides. These are useful in stimulating GH release and stimulating animal growth. warm-blooded non-human including also using To improve aquaculture

Claims (9)

1. The process of fabricating a compound with formula (I) (chemical formula) or parts of this substance. It is bioactive where R is (chemical formula) consisting of (a) prepared compound formula (II) with at least one protection group (chemical formula), where (chemical formula) may be hydrogen or defense group and (X8) may be. Is amide or hydroxyl Or protection group, and (b) remove the protection group or such group in the formula (II) compound to obtain formula (I) peptide or bioactive fragment and, if desired (c), replace the peptide. The resulting salt is a non-toxic salt. 2. The process mentioned in claim 1 where R34 is (chemical formula). 3. The process mentioned in Clause 1 or No. 2, where R34 is (chemical formula). 4. The process mentioned in one of the claims 1-3, where R is NH2. 5. The process of mentioned in one of the claims from 1-3, where R is OH. 6. The process as mentioned in claim No. 1, where the formula of the substance It is assembled as follows (chemical formula) 7. As mentioned in any of the claims of 1-6, where X1 is hydrogen or alpha-amino protection group, X2 is hydrogen or phenolic hydroxy protective group of (formula Chemistry) is the hydrogen or carboxyl group of Asp or (chemical formula) X4 is hydrogen or L protection group. The hydroxy alcohol of (chemical formula) X5 is the hydrogen or alcohol protection group, the hydroxy acid of (chemical formula) X6 is the hydrogen or the valence moic of (chemical formula) X7. Is the hydrogen or amino protective group. The side of (chemical formula) and X8 are selected from the type containing OH, OCH3 esters, amides, hydrazides, (chemical formula) resins, and NH-resin support 8. The process as mentioned in Clause 7, where X1-X8 is the chemical formula. 9.Such a process in claim 7, where X1-X8 is the chemical formula (9 claims, 2 pages, 0 images).