TH176462A - New immunosuppressive therapies against many tumors, including gastric and intestinal cancers. - Google Patents
New immunosuppressive therapies against many tumors, including gastric and intestinal cancers.Info
- Publication number
- TH176462A TH176462A TH1201004820A TH1201004820A TH176462A TH 176462 A TH176462 A TH 176462A TH 1201004820 A TH1201004820 A TH 1201004820A TH 1201004820 A TH1201004820 A TH 1201004820A TH 176462 A TH176462 A TH 176462A
- Authority
- TH
- Thailand
- Prior art keywords
- involved
- seq
- cells
- peptide
- tumor
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract 5
- 206010017758 Gastric cancer Diseases 0.000 title 1
- 230000001506 immunosuppresive Effects 0.000 title 1
- 201000002313 intestinal cancer Diseases 0.000 title 1
- 201000011549 stomach cancer Diseases 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract 5
- 210000004027 cells Anatomy 0.000 claims abstract 4
- 230000028993 immune response Effects 0.000 claims abstract 4
- 229960005486 vaccines Drugs 0.000 claims abstract 4
- 230000000259 anti-tumor Effects 0.000 claims abstract 3
- 201000011510 cancer Diseases 0.000 claims abstract 2
- 239000000470 constituent Substances 0.000 claims abstract 2
- 230000001472 cytotoxic Effects 0.000 claims abstract 2
- 231100000433 cytotoxic Toxicity 0.000 claims abstract 2
- 238000001647 drug administration Methods 0.000 claims abstract 2
- 230000001900 immune effect Effects 0.000 claims abstract 2
- 108020004707 nucleic acids Proteins 0.000 claims abstract 2
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 2
- 230000003285 pharmacodynamic Effects 0.000 claims abstract 2
- 230000001225 therapeutic Effects 0.000 claims abstract 2
- 210000004881 tumor cells Anatomy 0.000 claims abstract 2
- 210000001744 T-Lymphocytes Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
Abstract
DC60 (18/12/55) การประดิษฐ์นี้เกี่ยวข้องกับเปปไทด์, กรดนิวคลีอิคและเซลล์สำหรับใช้ในวิธีการรักษา ทางภูมิคุ้มกัน โดยเฉพาะอย่างยิ่ง, การประดิษฐ์นี้เกี่ยวข้องกับการรักษาทางภูมิคุ้มกันของมะเร็ง การประดิษฐ์นี้่ยังเกี่ยวข้องกับอีพิโทปของเปปไทด์ของ T เซลล์ที่เป็นพิษต่อเซลล์ (CTL) เกี่ยวข้องกับ เนื้องอก, อย่างเดียวหรือในการรวมกันกับเปปไทด์ที่เกี่ยวกับเนื้องอกอื่นซึ่งทำหน้าที่เป็นส่วนประกอบ ออกฤทธิ์ทางเภสัชกรรมขององค์ประกอบวัคซีนซึ่งกระตุ้นการตอบสนองภูมิคุ้มกันในการต้านเนื้องอก การประดิษฐ์นี้เกี่ยวข้องกับ 95 ลำดับเปปไทด์ใหม่และตัวแปรของสิ่งเหล่านี้ที่ได้รับจากโมเลกุล HLA กลุ่ม I ของเซลล์เนื้องอกของมนุษย์ที่สามารถถูกใช้ในองค์ประกอบวัคซีนสำหรับการแสดงการ ตอบสนองภูมิคุ้มกันในการต้านเนื้องอก สิทธิบัตรยา DC60 (18/12/55) This invention involves peptides, nucleic acids and cells for therapeutic use. Immune In particular, this invention relates to the immunological treatment of cancer. The invention also involved epitope of T cell cytotoxic peptide (CTL) involved in tumors, alone or in combination with other tumor-related peptides that act. Constituted The pharmacodynamic effect of the vaccine component stimulates the antitumor immune response. The invention involved 95 new peptide sequences and variants of them derived from the HLA group I molecules of human tumor cells that could be used in vaccine constituents for drug administration. Immune response in anti-tumor drug patent
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH176462A true TH176462A (en) | 2018-06-07 |
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