TH175849A - Piperidinone derivatives as MDM2 inhibitors for cancer treatment - Google Patents
Piperidinone derivatives as MDM2 inhibitors for cancer treatmentInfo
- Publication number
- TH175849A TH175849A TH1201006296A TH1201006296A TH175849A TH 175849 A TH175849 A TH 175849A TH 1201006296 A TH1201006296 A TH 1201006296A TH 1201006296 A TH1201006296 A TH 1201006296A TH 175849 A TH175849 A TH 175849A
- Authority
- TH
- Thailand
- Prior art keywords
- cancer treatment
- formula
- alkyl
- mdm2 inhibitors
- mdm2
- Prior art date
Links
- 102100019155 MDM2 Human genes 0.000 title abstract 5
- 101700032565 MDM2 Proteins 0.000 title abstract 5
- 239000003112 inhibitor Substances 0.000 title abstract 5
- 230000002401 inhibitory effect Effects 0.000 title abstract 5
- 201000011510 cancer Diseases 0.000 title abstract 3
- XUWHAWMETYGRKB-UHFFFAOYSA-N 2-Piperidinone Chemical class O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 4
- 239000003814 drug Substances 0.000 claims abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 6
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000005426 pharmaceutical component Substances 0.000 abstract 2
Abstract
DC60 (01/03/56) การประดิษฐ์นี้จัดให้มีสารประกอบตัวยับยั้ง MDM2 จากสูตร I สูตร (I), โดยที่ตัวแปรถูกกำหนดไว้ข้างต้นซึ่งสารประกอบสามารถนั้นมีประโยชน์คือเป็นสารกระทำ เชิงบำบัด โดยเฉพาะอย่างยิ่งสำหรับรักษาโรคมะเร็ง นอกจากนี้การประดิษฐ์นี่ยังเกี่ยว กับองค์ประกอบเภสัชภัณฑ์ซึ่งมีตัวยับยั้ง MDM2 การประดิษฐ์นี้จัดให้มีสารประกอบตัวยับยั้ง MDM2 จากสูตร (I), ที่ซึ่งตัวแปรได้ ถูกกำหนดไว้ข้างต้น, ซึ่งสารประกอบสามารถใช้ประโยชน์เป็นสารบำบัดรักษาโรค, โดยเฉพาะ อย่างยิ่งสำหรับรักษาโรคมะเร็ง การะประดิษฐ์นี่ยังเกี่ยวข้องกับองค์ประกอบทางเภสัชกรรมที่ ประกอบด้วยสารยับยั้ง MDM2 สิทธิบัตรยา DC60 (01/03/56) This invention provides MDM2 inhibitor compounds from formula I formula (I), where the above-defined variables can be useful as therapeutic agents. For cancer treatment In addition, this invention is about With a pharmaceutical component containing an MDM2 inhibitor, the invention provides an MDM2 inhibitor compound from the formula (I), where the variable Was defined above, where the compound could be used as a therapeutic agent, especially for the treatment of cancer. This is also related to the pharmaceutical components that Contains patented MDM2 inhibitors
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH175849A true TH175849A (en) | 2018-05-17 |
Family
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