TH175742B - High temperature stable second type of bonomorphogenetic protein Using fusion proteins Recombinant Statorin - Fibronectin And that process of preparation - Google Patents
High temperature stable second type of bonomorphogenetic protein Using fusion proteins Recombinant Statorin - Fibronectin And that process of preparationInfo
- Publication number
- TH175742B TH175742B TH1701005131A TH1701005131A TH175742B TH 175742 B TH175742 B TH 175742B TH 1701005131 A TH1701005131 A TH 1701005131A TH 1701005131 A TH1701005131 A TH 1701005131A TH 175742 B TH175742 B TH 175742B
- Authority
- TH
- Thailand
- Prior art keywords
- protein
- type
- fibronectin
- statorin
- high temperature
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title claims abstract 4
- 108090000623 proteins and genes Proteins 0.000 title claims abstract 4
- 102000016359 Fibronectins Human genes 0.000 title claims 2
- 108010067306 Fibronectins Proteins 0.000 title claims 2
- 102000037865 fusion proteins Human genes 0.000 title abstract 2
- 108020001507 fusion proteins Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims abstract 3
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims abstract 3
- 230000004927 fusion Effects 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 abstract 4
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 abstract 4
- 229940112869 bone morphogenetic protein Drugs 0.000 abstract 3
- 230000004071 biological effect Effects 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 230000001002 morphogenetic effect Effects 0.000 abstract 1
- 230000017854 proteolysis Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับกระบวนการปกป้องการเสื่อมสภาพของโปรตีนโบนมอร์โฟเจเนติก ชนิดที่สองสำหรับการใช้งานภายใต้สภาวะที่มีอุณหภูมิสูง โดยการนำโปรตีนฟิวชันรีคอมบิแนนท์ สแตเทอริน-ไฟโบรเนคติกมาผสมกับโปรตีนโบนมอร์โฟเจเนติกชนิดที่สอง ด้วยสัดส่วนของโปรตีน โบนมอร์โฟเจเนติกชนิดที่สองและโปรตีนฟิวชันรีคอมบิแนนท์สแตเทอริน-ไฟโบรเนคตินเป็น 15 จึงจะ ส่งผลให้สามารถป้องกันการเสื่อมสภาพของโปรตีนโบนมอร์โฟเจเนติกชนิดที่สองในระหว่างที่ใช้งาน ภายใต้สภาวะที่มีอุณหภูมิสูงถึง 90 องศาเซลเซียส ภายในเวลา 1 ชั่วโมง นอกเหนือจากนั้นยังส่งผลในการ ช่วยเสริมการออกฤทธิ์ทางชีวภาพของโปรตีนโบนมอร์โฟเจเนติกชนิดที่สองให้สูงขึ้น 6 เท่า: The present invention relates to a process of protecting against degradation of bone morphogenetic proteins. The second type is for use under high temperature conditions. By using recombinant fusion proteins Statorin-fibronectin is combined with a second bone morphogenetic protein. With the proportion of protein The second type of bone morphogenetic and recombinant statherin-fibronectin fusion protein was 15 thus able to prevent bone protein degradation. The second type of morphogenetic during its use Under conditions with temperatures as high as 90 degrees Celsius within 1 hour, in addition to that, it also results in Enhances the biological activity of the second type of bone morphogenetic protein by 6 times:
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH175742B true TH175742B (en) | 2018-05-10 |
| TH175742A TH175742A (en) | 2018-05-10 |
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