TH174504A - Derivative of 2,3-disusstitudate 1-azyl-4-amino-1,2,3,4-tetrahydroquinone And their use as a bromodomain inhibitor. - Google Patents
Derivative of 2,3-disusstitudate 1-azyl-4-amino-1,2,3,4-tetrahydroquinone And their use as a bromodomain inhibitor.Info
- Publication number
- TH174504A TH174504A TH1501005420A TH1501005420A TH174504A TH 174504 A TH174504 A TH 174504A TH 1501005420 A TH1501005420 A TH 1501005420A TH 1501005420 A TH1501005420 A TH 1501005420A TH 174504 A TH174504 A TH 174504A
- Authority
- TH
- Thailand
- Prior art keywords
- alkyl
- compound
- bromodomain inhibitor
- available
- disusstitudate
- Prior art date
Links
- 102000001805 Bromodomains Human genes 0.000 title claims abstract 3
- 108050009021 Bromodomains Proteins 0.000 title claims abstract 3
- 239000003112 inhibitor Substances 0.000 title claims abstract 3
- 230000002401 inhibitory effect Effects 0.000 title claims abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 10
- 150000001875 compounds Chemical class 0.000 claims abstract 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims abstract 3
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drugs Drugs 0.000 claims abstract 2
- 125000005843 halogen group Chemical group 0.000 claims abstract 2
- 125000005842 heteroatoms Chemical group 0.000 claims abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 2
- 239000005426 pharmaceutical component Substances 0.000 claims abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Abstract
คำขอใหม่ปรับปรุงวันที่ 7/03/2559 การประดิษฐ์นี้เกี่ยวกับสารประกอบใหม่ของสูตร (I), ซึ่ง R1 คือ C1-4แอลคิล; R2 คือ C1-4 แอลคิล, C3-7 ไซโคลแอลคิล, -CH2CF3, -CH2OCH3 หรือเฮเทโรไซคลิล; R3 คือ C1-4แอลคิล, -CH2F, -CH2OH หรือ -CH2O(O)CH3;R4 เมื่อมี เป็นตามที่นิยามในข้อถือสิทธิข้อ 1;R5 เมื่อมี คือ H,แฮโล, ไฮดรอกซิ หรือ C1-6 แอลคอกซิ; A คือ -NH-, -O-, -S-, -SO-, -SO2-, -N(C1-4แอลคิล)- หรือ -NC(O)(CH)-; V คือ เฟนิล, เฮเทโรแอโรแมติก หรือ พิริโดน ซึ่งอาจจะเลือกให้หมู่ใดหมู่หนึ่งให้ถูก แทนที่โดย 1, 2 หรือ 3 หมู่แทนที่; W คือ CH หรือ N; X คือ C หรือ N; Y คือ C หรือ N; และ Z คือ CH หรือ N; ด้วยเงื่อนไขว่า ไม่เกิน 2 ของ W, X, Y และ Z เป็น N, องค์ประกอบทางเภสัชกรรมที่มี สารประกอบดังกล่าว และกับการใช้มันตัวยับยั้งโบรโมโดเมน: สิทธิบัตรยา New request updated 07/03/2016 This invention relates to a new compound of formula (I), of which R1 is C1-4 alkyl; R2 is C1-4 alkyl, C3-7 cycloalkyl, -CH2CF3, -CH2OCH3 or heterocyclil; R3 is C1-4 alkyl, -CH2F, -CH2OH, or -CH2O (O) CH3; R4 when available, as defined in claim 1; R5 where available is H, halo, hydroxyl. Or C1-6 Lcoxin; A is -NH-, -O-, -S-, -SO-, -SO2-, -N (C1-4 alkyl) - or -NC (O) (CH) -; V is phenyl, Hetero, aerobic, or piridone, which may choose to be replaced by either group 1, 2 or 3; W is CH or N; X is C or N; Y is C or N; And Z is CH or N; Provided that no more than 2 of W, X, Y, and Z are N, the active pharmaceutical component Such compound And with its use, bromodomain inhibitor: drug patent
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH174504A true TH174504A (en) | 2018-03-16 |
| TH1501005420A TH1501005420A (en) | 2018-03-16 |
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