TH17364A - - Google Patents
Info
- Publication number
- TH17364A TH17364A TH9401000157A TH9401000157A TH17364A TH 17364 A TH17364 A TH 17364A TH 9401000157 A TH9401000157 A TH 9401000157A TH 9401000157 A TH9401000157 A TH 9401000157A TH 17364 A TH17364 A TH 17364A
- Authority
- TH
- Thailand
- Prior art keywords
- lys
- glu
- thr
- val
- asp
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims abstract 13
- 239000000126 substance Substances 0.000 claims abstract 6
- SITLTJHOQZFJGG-XPUUQOCRSA-N Glu-Val Chemical group CC(C)[C@@H](C(O)=O)NC(=O)[C@@H](N)CCC(O)=O SITLTJHOQZFJGG-XPUUQOCRSA-N 0.000 claims 4
- VEGLGAOVLFODGC-GUBZILKMSA-N Lys-Glu-Ser Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O VEGLGAOVLFODGC-GUBZILKMSA-N 0.000 claims 4
- ULUQBUKAPDUKOC-GVXVVHGQSA-N Lys-Glu-Val Chemical group [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(O)=O ULUQBUKAPDUKOC-GVXVVHGQSA-N 0.000 claims 4
- SITLTJHOQZFJGG-UHFFFAOYSA-N N-L-alpha-glutamyl-L-valine Chemical group CC(C)C(C(O)=O)NC(=O)C(N)CCC(O)=O SITLTJHOQZFJGG-UHFFFAOYSA-N 0.000 claims 4
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
- LPMNLSKIHQMUEJ-UHFFFAOYSA-N 2-[2-[[2-[[2-[(2-amino-3-methylbutanoyl)amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]propanoylamino]pentanedioic acid;azane Chemical compound N.CC(C)C(N)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(C)C(=O)NC(CCC(O)=O)C(O)=O LPMNLSKIHQMUEJ-UHFFFAOYSA-N 0.000 claims 2
- LLSUNJYOSCOOEB-GUBZILKMSA-N Lys-Glu-Asp Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(O)=O LLSUNJYOSCOOEB-GUBZILKMSA-N 0.000 claims 2
- 108010005233 alanylglutamic acid Chemical group 0.000 claims 2
- LIWMQSWFLXEGMA-WDSKDSINSA-N Ala-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](C)N LIWMQSWFLXEGMA-WDSKDSINSA-N 0.000 claims 1
- LKDIBBOKUAASNP-FXQIFTODSA-N Glu-Ala-Glu Chemical group OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(O)=O LKDIBBOKUAASNP-FXQIFTODSA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical group NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- WPSKTVVMQCXPRO-BWBBJGPYSA-N Thr-Ser-Ser Chemical group [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(O)=O WPSKTVVMQCXPRO-BWBBJGPYSA-N 0.000 claims 1
- 239000012634 fragment Substances 0.000 abstract 1
Abstract
สารประกอบที่มีสูตรดังนี้ R1-X-R2-Y (I) ซึ่ง X คือ Ser-Asp-Ala-Ab-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp- Leu-Lys-Glu-Lys-Lys-Glu-Val-Glu-Glu-Ala-Glu หรือนุพันธ์ หรือชิ้นส่วน ของลำดับเหล่านี้ ที่ออกฤทธิ์ได้ในทางชีววิทยา R1 คือ Ac หรือ Z ซึ่ง Ac คือ หมู่อาซีติค และ Z คือ (สูตรเคมี) ซึ่ง Ac และ X มีความหมายดังที่กำหนดไว้ข้างบน R2 คือ Asn หรือ Asp สิทธิบัตรยา
Claims (2)
1. สารประกอบของข้อถือสิทธิข้อ 3 ซึ่ง X2 คือ Z-Ser-Asp-Ala-Ala-Val- Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys- Glu-Val, ซึ่ง Z ใช้แทนได้ด้วยสูตรดังนี้ (สูตรเคมี) ซึ่ง R3 คือ Asn และ X3 คือ X4-Val-Glu-Glu-Ala-Glu, ซึ่ง X4 คือ Lys-Asp-Leu-Lys-Glu-lys-Lys-Glu-Val, Thr- Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val, Thr-Thr-Lys-Asp-Leu-Lys- Glu-Lys-Lys-Glu-Val, Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys- Glu-Val, Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val, Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val หรือ Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val. 1
2. สารประกอบของข้อถือสิทธิข้อ 3 ซึ่ง X2 คือ Z-Ser-Asp-Ala-Ala- Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys- Lys-Glu-Val, ซึ่ง Z ใช้แทนได้ด้วยสูตรดังนี้ (สูตรเคมี) ซึ่ง R3 คือ Asn และ X3 คือ X4-Val-Glu-Glu-Ala-Glu, ซึ่ง X4 คือ Thr-Ser-Ser-Glu-Ile,Thr-Thr-Lys-Asp-Leu- Lys-Glu-Lys-Lys-Glu-Val, Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys- Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val, Val-Asp-Thr-Ser-Ser-Glu-Ile- Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val, Ala-Val-Asp-Thr- Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val, Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys- Glu-Lys-Lys-Glu-Val, Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile- Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val หรือ Ser-Asp-Ala- Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu- Lys-Lys-Glu-Val.
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH17364A true TH17364A (th) | 1996-01-11 |
| TH15241B TH15241B (th) | 2003-08-27 |
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