TH171924A - Compound 6,7-dihydropyrazolo [1,5-a] pyrazine-4 (5H) - transfer, and its use as a mGluR2 ellosteric inhibitor. Setter - Google Patents
Compound 6,7-dihydropyrazolo [1,5-a] pyrazine-4 (5H) - transfer, and its use as a mGluR2 ellosteric inhibitor. SetterInfo
- Publication number
- TH171924A TH171924A TH1501007226A TH1501007226A TH171924A TH 171924 A TH171924 A TH 171924A TH 1501007226 A TH1501007226 A TH 1501007226A TH 1501007226 A TH1501007226 A TH 1501007226A TH 171924 A TH171924 A TH 171924A
- Authority
- TH
- Thailand
- Prior art keywords
- mglur2
- compounds
- dihydropyrazolo
- transfer
- involved
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 8
- 102100006616 GRM2 Human genes 0.000 title claims abstract 6
- 108010038421 metabotropic glutamate receptor 2 Proteins 0.000 title claims abstract 6
- 239000003112 inhibitor Substances 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 claims abstract 4
- 108010010914 Metabotropic Glutamate Receptors Proteins 0.000 claims abstract 2
- 102000016193 Metabotropic Glutamate Receptors Human genes 0.000 claims abstract 2
- 230000003281 allosteric Effects 0.000 claims abstract 2
- 230000000051 modifying Effects 0.000 claims abstract 2
- 239000005426 pharmaceutical component Substances 0.000 claims abstract 2
- 230000002265 prevention Effects 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 230000002503 metabolic Effects 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับอนุพันธ์ 6,7-ไดไฮโดรไพราโซโล[1,5-a]ไพรามีน-4(5H)-โอน ชนิดใหม่ตามสูตร (I) ในฐานะเป็นสารยับยั้งแอลโลสเตอริก (negative allosteric modulators, NAMs) ของเมทาบอทรปิกกลูตาเมตรีเซ็ปเตอร์ชนิดย่อย 2 (metabotropic glutamate receptor subtype 2, "mGluR2") นอกจากนั้นการประดิษฐ์เกี่ยวข้องกับองค์ประกอบทางเภสัชกรรมซึ่งประกอบรวมด้วย สารประกอบดังกล่าว, เกี่ยวข้องกับกระบวนการสำหรับเตรียมสารประกอบและองค์ประกอบดังกล่าว, และเกี่ยวข้องกับการใช้สารประกอบและองค์ประกอบดังกล่าว สำหรับการป้องกัน หรือการบำบัด ความผิดปกติ ที่ซึ่งเกี่ยวข้องกับเมทาบอโทรปิกรีเซ็ปเตอร์ชนิดย่อย mGluR2 โดยเฉพาะอย่างยิ่งความ ผิดปกติ CNS สิทธิบัตรยา This invention is related to the derivative. 6,7-dihydropyrazolo [1,5-a] pyramine-4 (5H) - transfer A new type of formula (I) as a negative allosteric modulators (NAMs) of metabotropic glutamate receptor subtype 2, " mGluR2 ”). In addition, the invention is related to the pharmaceutical components which include Such compounds, involved in the process for the preparation of such compounds and elements, are involved in the use of such compounds and elements. For the prevention or treatment of disorders associated with the mGluR2 subtypes mGluR2, especially the patented CNS disorder.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH171924A true TH171924A (en) | 2018-01-04 |
| TH1501007226A TH1501007226A (en) | 2018-01-04 |
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