TH1701002216A - Functional indolcarboxamides as inhibitors of kinase - Google Patents
Functional indolcarboxamides as inhibitors of kinaseInfo
- Publication number
- TH1701002216A TH1701002216A TH1701002216A TH1701002216A TH1701002216A TH 1701002216 A TH1701002216 A TH 1701002216A TH 1701002216 A TH1701002216 A TH 1701002216A TH 1701002216 A TH1701002216 A TH 1701002216A TH 1701002216 A TH1701002216 A TH 1701002216A
- Authority
- TH
- Thailand
- Prior art keywords
- compound
- disclosed
- formula
- disease
- salt
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title claims abstract 3
- 230000002401 inhibitory effect Effects 0.000 title claims abstract 3
- VFHUJFBEFDVZPJ-UHFFFAOYSA-N 1H-indole-2-carboxamide Chemical class C1=CC=C2NC(C(=O)N)=CC2=C1 VFHUJFBEFDVZPJ-UHFFFAOYSA-N 0.000 title 1
- 102000030951 Phosphotransferases Human genes 0.000 title 1
- 108091000081 Phosphotransferases Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 9
- 150000003839 salts Chemical class 0.000 claims abstract 3
- 239000011780 sodium chloride Substances 0.000 claims abstract 3
- 239000000126 substance Substances 0.000 claims abstract 3
- 206010003816 Autoimmune disease Diseases 0.000 claims abstract 2
- 206010061818 Disease progression Diseases 0.000 claims abstract 2
- 201000009596 autoimmune hypersensitivity disease Diseases 0.000 claims abstract 2
- 201000010099 disease Diseases 0.000 claims abstract 2
- 239000005426 pharmaceutical component Substances 0.000 claims abstract 2
- 230000002265 prevention Effects 0.000 claims abstract 2
- 230000001225 therapeutic Effects 0.000 claims abstract 2
- 201000011528 vascular disease Diseases 0.000 claims abstract 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 102000001714 Agammaglobulinaemia Tyrosine Kinase Human genes 0.000 abstract 1
- 108010029445 Agammaglobulinaemia Tyrosine Kinase Proteins 0.000 abstract 1
Abstract
ที่เปิดเผยคือ สารประกอบของสูตร (I) (สูตรเคมี) (I) หรือ เกลือของมัน, ซึ่ง: X คือ CR4 หรือ N; R1, R2, R3, R4, และ A ได้ถูกนิยามไว้ในที่นี้ ที่เปิดเผยไว้ เช่นกันคือวิธีใช้ สารประกอบดังกล่าวเป็นสารยับยั้งของ Bruton's tyrosine kinase (Btk), และ องค์ประกอบทางเภสัชกรรม ซึ่งประกอบรวมด้วยสารประกอบดังกล่าว สารประกอบเหล่านี้ใช้ ประโยชน์ในการรักษา, การป้องกัน, หรือการหน่วง ในความก้าวหน้าของโรคหรือความผิดปกติ ในบริเวณที่ต้องทำการรักษา (therapeutic areas) ต่างๆ, เช่น โรคภูมิคุ้มกันต้านตนเอง (autoimmune disease) และโรคหลอดเลือด (vascular disease): Disclosed is The compound of formula (I) (chemical formula) (I) or its salt, in which: X is CR4 or N; R1, R2, R3, R4, and A are defined here. Disclosed As well is how to use The compound is an inhibitor of Bruton's tyrosine kinase (Btk), and a pharmaceutical component. Which consists of those compounds These compounds are used Useful as a treatment, prevention, or delay in disease progression or disorder In therapeutic areas, such as autoimmune disease and vascular disease:
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH1701002216A true TH1701002216A (en) | 2019-05-17 |
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