TH169445B - Manufacturing methods 2-fluoro-4-borono-L-phenylalanine and its precursors 2-fluoro-4-borono-L-phenylalanine - Google Patents
Manufacturing methods 2-fluoro-4-borono-L-phenylalanine and its precursors 2-fluoro-4-borono-L-phenylalanineInfo
- Publication number
- TH169445B TH169445B TH1601003559A TH1601003559A TH169445B TH 169445 B TH169445 B TH 169445B TH 1601003559 A TH1601003559 A TH 1601003559A TH 1601003559 A TH1601003559 A TH 1601003559A TH 169445 B TH169445 B TH 169445B
- Authority
- TH
- Thailand
- Prior art keywords
- group
- borono
- phenylalanine
- fluoro
- iodine
- Prior art date
Links
- 102000014961 Protein Precursors Human genes 0.000 title 1
- 108010078762 Protein Precursors Proteins 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- OZAIFHULBGXAKX-UHFFFAOYSA-N precursor Substances N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 5
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000005467 butylenyl group Chemical group 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000005469 ethylenyl group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000005470 propylenyl group Chemical group 0.000 claims 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- -1 CI group Chemical group 0.000 abstract 4
- KGBXLFKZBHKPEV-UHFFFAOYSA-N Boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 abstract 2
- 239000004327 boric acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 2
- 229910052740 iodine Inorganic materials 0.000 abstract 2
- 239000011630 iodine Substances 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N iodine atom Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 2
- KTNLYTNKBOKXRW-UHFFFAOYSA-N phenyliodanium Chemical compound [IH+]C1=CC=CC=C1 KTNLYTNKBOKXRW-UHFFFAOYSA-N 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000005842 heteroatoms Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 abstract 1
Abstract
แก้ไข 9/9/2559 การประดิษฐ์นี้มีส่วนเกี่ยวข้องกับการเตรียมสารประกอบที่มีการแสดงแทนด้วยสูตรดังนี้ (ในสูตรดังกล่าว R1 แสดงแทนหมู่ Br, หมู่ไอโอดีน, หมู่ CI, หมู่ NO2 หรือหมู่ NH2, R2 แสดงแทน หมู่ฮาโลเจน, หมู่ NO2, หมู่ NH2, Sn(R6)3, N=N-NR7R8, OSO2R9, N R10R11, เฟนิลไอโอโดเนียม, หมู่เฮเทอโรไซคลิกไอโอดีน, กรดบอริก หรือบอเรตเอสเตอร์, R30 แสดงแทนหมู่ปกป้อง PG1, R40 หรือ R50 แสดงแทนไฮโดรเจน, หมู่ปกป้อง PG2 หรือ C6H5(C6H5)C=N โดยที่ NR40R50 อยู่ใน ลักษณะประกอบเข้าด้วยกัน) ---------------------------------------------------------------------------------------- การประดิษฐ์นี้มีส่วนเกี่ยวข้องกับการเตรียมสารประกอบที่มีการแสดงแทนด้วยสูตรดังนี้ (ในสูตรดังกล่าว R1 แสดงแทนหมู่ Br, หมู่ไอโอดีน, หมู่ CI,หมู่NO2หรือหมู่ NH2,R2 แสดงแทน หมู่ฮาโลเจน, หมู่ NO2,หมู่ (สูตร) เฟนิลไอโอโดเนียม, หมู่เฮเทอโรไซคลิกไอโอดีน,กรดบอริก หรือบอเรตเอสเตอร์, R30 แสดงแทนหมู่ปกป้อง PG1, R40 หรือ R50 แสดงแทนไฮโดรเจน, หมู่ปกป้อง PG2 หรือ (สูตร) โดยที่ NR40 R50 อยู่ใน ลักษณะประกอบเข้าด้วยกัน) Revised 9/9/2016 This invention involved the preparation of compounds represented by formulas: (In the above formula, R1 represents Br group, Iodine group, CI group, NO2 group or NH2 group, R2 represents halogen group, NO2 group, NH2 group, Sn (R6) 3, N = N-NR7R8, OSO2R9. , N R10 R11, phenyl iodonium, heterocyclic iodine, boric acid or borate ester, R30 represents PG1, R40 or R50 protection group, PG2 or C6H5 protection group. (C6H5) C = N where NR40R50 is assembled) --------------------------------- -------------------------------------------------- ----- This invention involved the preparation of substituted compounds with the following formulas: (In the above formula, R1 represents Br group, Iodine group, CI group, NO2 group or NH2 group, R2 represents halogen group, NO2 group, group (formula) phenyl iodonium, hetero group. Cyclic iodine, boric acid Or borate ester, R30 represents the PG1, R40 or R50 protection group, the PG2 or (formula) hydrogen, the NR40 R50 is assembled).
Claims (1)
Publications (3)
| Publication Number | Publication Date |
|---|---|
| TH169445B true TH169445B (en) | 2017-10-19 |
| TH169445A TH169445A (en) | 2017-10-19 |
| TH1601003559A TH1601003559A (en) | 2017-10-19 |
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