TH168837A - Derivative of 4- alkyline imidazole and pharmaceutical products that contain it As an active ingredient - Google Patents
Derivative of 4- alkyline imidazole and pharmaceutical products that contain it As an active ingredientInfo
- Publication number
- TH168837A TH168837A TH1501007427A TH1501007427A TH168837A TH 168837 A TH168837 A TH 168837A TH 1501007427 A TH1501007427 A TH 1501007427A TH 1501007427 A TH1501007427 A TH 1501007427A TH 168837 A TH168837 A TH 168837A
- Authority
- TH
- Thailand
- Prior art keywords
- alkyline
- diseases
- imidazole
- derivative
- contain
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N Imidazole Chemical compound C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 2
- 239000004480 active ingredient Substances 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229940079593 drugs Drugs 0.000 claims abstract 4
- 239000003814 drug Substances 0.000 claims abstract 3
- 239000000126 substance Substances 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 239000011780 sodium chloride Substances 0.000 claims abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract 3
- 206010061218 Inflammation Diseases 0.000 abstract 2
- 101710011551 PTGER4 Proteins 0.000 abstract 2
- 230000001939 inductive effect Effects 0.000 abstract 2
- 230000004054 inflammatory process Effects 0.000 abstract 2
- 210000000447 Th1 Cells Anatomy 0.000 abstract 1
- 210000000068 Th17 Cells Anatomy 0.000 abstract 1
- 230000003213 activating Effects 0.000 abstract 1
- 230000003110 anti-inflammatory Effects 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 201000008175 pain disease Diseases 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 210000001519 tissues Anatomy 0.000 abstract 1
Abstract
สารอนุพันธ์ 4-แอลคินิลอิมิดาโซลหรือเกลือที่มีการอนุญาตให้มีเชิงเภสัชวิทยานั้น ซึ่งมีการแสดง โดยสูตรทั่วไป (I) ต่อไปนี้ซึ่งมีฤทธิ์ต้านรีเซปเตอร์ EP4 และมีประโยชน์สำหรับเป็นเวชภัณฑ์สำหรับ บำบัดโรคที่รีเซปเตอร์ EP4 เกี่ยวข้อง เช่น ยาระงับการอักเสบและ/หรือแก้ปวดของโรคที่มีสาเหตุมาก จากการอักเสบหรือโรคที่มีความปวดเกิดขึ้นร่วมด้วยแบบต่างๆ อีกทั้ง เป็นเวชภัณฑ์สำหรับบำบัดโรคที่ มีสาเหตุมาจากการภูมิคุ้มกันจากการทำให้เซลล์ Th1 และ/หรือเซลล์ Th17 มีแอกทิวิตี ทำให้เกิดการ ทำลายเนื้อเยื่อและเหนี่ยวนำให้เกิดการอักเสบ เคมี 1 (สูตรเคมี) --- (I) สิทธิบัตรยา 4-alkyline-imidazole derivatives or pharmacologic salts. Which has been shown The general formula (I) is effective against EP4 receptors and is useful as a pharmaceutical drug for Treat the diseases that EP4 receptors are involved in, such as anti-inflammatory drugs and / or pain relievers for the underlying disease. From inflammation or pain diseases that occur together with various forms, and is a medical product for the treatment of diseases that It is caused by immunity by activating Th1 and / or Th17 cells, inducing tissue destruction and inducing inflammation. Chemical 1 (Chemical formula) --- (I) Drug patent.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH1501007427A TH1501007427A (en) | 2017-10-12 |
| TH168837A true TH168837A (en) | 2017-10-12 |
Family
ID=
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1119490T1 (en) | PYRAZOLOPYROLIDINE PRODUCTS AND THEIR USE IN PATIENT TREATMENT | |
| MX2016013529A (en) | Amide derivatives and pharmaceutically acceptable salts thereof, preparation method therefor and medicinal application thereof. | |
| ECSP13012967A (en) | 1,3-OXAZINES AS INHIBITORS OF THE BACE1 AND / OR THE BACE2 | |
| ECSP13013068A (en) | HALOGENOALQUIL-1,3-OXAZINAS AS INHIBITORS OF THE BACE1 AND / OR BACE2 | |
| ECSP13013048A (en) | SPIRO- [1,3] -OXACINES AND SPIRO- [1,4] -OXACEPINS AS INHIBITORS | |
| BR112015030315A2 (en) | 4-alkynylimidazole derivative and medicament comprising the same as active ingredient | |
| ECSP13013024A (en) | 1,3-OXAZINES AS INHIBITORS OF BACE1 AND / OR BACE2 | |
| BR112014027841A8 (en) | Pyrazole derivative and its use for medical purposes | |
| EA201391029A1 (en) | OXAZIN DERIVATIVES AND THEIR APPLICATION IN THE TREATMENT OF NEUROLOGICAL DISORDERS | |
| UA113538C2 (en) | FLUOROMETHYL-5,6-DIHYDRO-4H- $ 1,3] OXAZINES | |
| GT201400059A (en) | DERIVATIVES OF ESTRA-1,3,5 (10), 16-TETRAEN-3-CARBOXAMIDE, PROCEDURES FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS THAT CONTAIN THEM, AS WELL AS THEIR USE FOR THE PREPARATION OF MEDICINES | |
| PH12015502365B1 (en) | Bace1 inhibitors | |
| EA201501164A1 (en) | SOLID PHARMACEUTICAL MEDICINE FORM | |
| TR201905218T4 (en) | USEFUL VITANOLIDES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES. | |
| CL2017002229A1 (en) | Bace1 inhibitors. | |
| TR201908151T4 (en) | Isoindoline derivatives. | |
| EA201691058A1 (en) | DERIVATIVES OF PYRROLOPIRROLON AND THEIR APPLICATION FOR THE TREATMENT OF DISEASES | |
| TH168837A (en) | Derivative of 4- alkyline imidazole and pharmaceutical products that contain it As an active ingredient | |
| AR107752A1 (en) | BACE1 INHIBITORS | |
| TH152517A (en) | Dipluoro-hexahydro-cyclopentahoxinil and dipluoro-hexahydro-benzooxinil as BACE1 inhibitors. | |
| CY1122561T1 (en) | BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS | |
| TH1801001591A (en) | Therapeutic or prophylactic agents of fungal cornealitis | |
| TH169293A (en) | BACEI inhibitors | |
| CU20160170A7 (en) | CARBOXAMIDE DERIVATIVES | |
| TH166182A (en) | "Pharmaceutical mixtures for the prevention or treatment of skin rashes" |