TH168664A - Rats with major Histoompatibility The complex was genetically modified. - Google Patents
Rats with major Histoompatibility The complex was genetically modified.Info
- Publication number
- TH168664A TH168664A TH1401001713A TH1401001713A TH168664A TH 168664 A TH168664 A TH 168664A TH 1401001713 A TH1401001713 A TH 1401001713A TH 1401001713 A TH1401001713 A TH 1401001713A TH 168664 A TH168664 A TH 168664A
- Authority
- TH
- Thailand
- Prior art keywords
- human
- genetically modified
- polypeptide
- animals
- major
- Prior art date
Links
- 241000700159 Rattus Species 0.000 title claims abstract 3
- 241000282414 Homo sapiens Species 0.000 claims abstract 16
- 229920001184 polypeptide Polymers 0.000 claims abstract 7
- 241001465754 Metazoa Species 0.000 claims abstract 4
- 108091006028 chimera Proteins 0.000 claims abstract 3
- 241000282412 Homo Species 0.000 claims abstract 2
- 210000000987 Immune System Anatomy 0.000 claims abstract 2
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims abstract 2
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims abstract 2
- 210000004027 cells Anatomy 0.000 claims abstract 2
- 210000002257 embryonic structures Anatomy 0.000 claims abstract 2
- 210000001519 tissues Anatomy 0.000 claims abstract 2
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000006011 modification reaction Methods 0.000 claims 1
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 1
Abstract
DC60 (25/06/57) หนูที่มีเมเจอร์ ฮิสโตคอมแพทาบิลิตี้ คอมเพลกซ์ซึ่งถูกดัดแปลงทางพันธุกรรม การประดิษฐ์นี้ได้จัดให้มีสัตว์ที่ไม่ใช่มนุษย์ซึ่งถูกดัดแปลงทางพันธุกรรมที่แสดงไคเมอริก MHC I โพลีเปปไทด์ของมนุษย์/ที่ไม่ใช่ของมนุษย์ หรือ เบตา2 ไมโครโกลบูลิน โพลีเปปไทด์ที่ถูกทำ ให้เหมือนของมนุษย์ พร้อมทั้ง เอมบริโอ, เซลล์ และ เนื้อเยื่อที่ประกอบด้วยสิ่งเดียวกันนั้น ทั้งยังได้ จัดให้มีสิ่งสร้างสำหรับการสร้างสัตว์ดัดแปลงพันธุกรรมดังกล่าว และวิธีการของการสร้างสิ่ง เดียวกันนั้น วิธีการของการใช้สัตว์ดัดแปลงพันธุกรรมเพื่อศึกษาแง่มุมต่างๆ ของระบบภูมิคุ้มกัน ของมนุษย์ได้ถูกจัดให้มีขึ้น DC60 (25/06/57) Rats with Major Histoompatibility The complex was genetically modified. This invention provides a genetically engineered non-human animal showing the human / non-human chimeric MHC I polypeptide or beta 2 microglobulin. Polypeptide that has been made It is the same as that of humans, with embryos, cells and tissues that comprise the same thing, and provides for the creation of these genetically modified animals. And methods of creating the same; methods of using genetically modified animals to study various aspects. Of the immune system Of human beings has been made
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH168664A true TH168664A (en) | 2017-10-05 |
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