TH167999A - 1,3-benzodiazole derivatives - Google Patents
1,3-benzodiazole derivativesInfo
- Publication number
- TH167999A TH167999A TH1601005342A TH1601005342A TH167999A TH 167999 A TH167999 A TH 167999A TH 1601005342 A TH1601005342 A TH 1601005342A TH 1601005342 A TH1601005342 A TH 1601005342A TH 167999 A TH167999 A TH 167999A
- Authority
- TH
- Thailand
- Prior art keywords
- group
- salt
- formula
- compound
- general formula
- Prior art date
Links
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical class C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims abstract 7
- 150000003839 salts Chemical class 0.000 claims abstract 5
- 239000011780 sodium chloride Substances 0.000 claims abstract 5
- 239000000126 substance Substances 0.000 claims abstract 5
- 102100016041 EZH2 Human genes 0.000 claims abstract 4
- 101700041849 EZH2 Proteins 0.000 claims abstract 4
- 101700017378 EZH1 Proteins 0.000 claims abstract 2
- 239000000470 constituent Substances 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drugs Drugs 0.000 claims abstract 2
- 230000000694 effects Effects 0.000 claims abstract 2
- 230000002401 inhibitory effect Effects 0.000 claims abstract 2
- 230000000144 pharmacologic effect Effects 0.000 claims abstract 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Abstract
การประดิษฐ์นี้ให้สารประกอบที่มีโครงสร้างเคมีที่เฉพาะ หรือ เกลือซึ่งเป็นที่ยอมรับทาง เภสัชวิทยาของมัน ซึ่งมีผลยับยั้งดีเลิศต่อ EZH1 และ/หรือ EZH2 แอคทิวิที การประดิษฐ์นี้ให้ สารประกอบที่มีโครงสร้าง 1,3-เบนโซไดออกโซล ซึ่งแทนโดยสูตรทั่วไป (I) หรือ เกลือซึ่งเป็นที่ ยอมรับทางเภสัชวิทยาของมัน, หรือ องค์ประกอบทางเภสัชกรรมซึ่งประกอบรวมด้วย สารประกอบ (ซึ่ง R1, R2, R3, R4, R5, R6, และ V ในสูตร (I) แต่ละหมู่มีความหมายตามที่ได้นิยามไว้ในรายละเอียด ของการประดิษฐ์นี้) (สูตรเคมี) (I) สิทธิบัตรยา This invention provides a compound with a specific chemical structure, or a salt that is technically acceptable. Its pharmacology Which has excellent inhibitory effects on EZH1 and / or EZH2 activity. Structured compound 1,3-benzodiazole Which is represented by the general formula (I) or salt, which is Its pharmacological, or pharmaceutical constituents are composed of compounds (where R1, R2, R3, R4, R5, R6, and V in the formula (I) each have their meaning as described in detail. Of this invention) (chemical formula) (I) patent drug
Claims (1)
Publications (2)
Publication Number | Publication Date |
---|---|
TH167999A true TH167999A (en) | 2017-09-21 |
TH167999B TH167999B (en) | 2017-09-21 |
Family
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TH167999A (en) | 1,3-benzodiazole derivatives | |
TH167999B (en) | 1,3-benzodiazole derivatives |