TH167877B - A new formula for gonadotropin - Google Patents
A new formula for gonadotropinInfo
- Publication number
- TH167877B TH167877B TH1601002207A TH1601002207A TH167877B TH 167877 B TH167877 B TH 167877B TH 1601002207 A TH1601002207 A TH 1601002207A TH 1601002207 A TH1601002207 A TH 1601002207A TH 167877 B TH167877 B TH 167877B
- Authority
- TH
- Thailand
- Prior art keywords
- buffer
- gonadotropin
- godotropin
- aggregation
- new formula
- Prior art date
Links
- 102000006771 Gonadotropins Human genes 0.000 title claims abstract 3
- 108010086677 Gonadotropins Proteins 0.000 title claims abstract 3
- 239000002622 gonadotropin Substances 0.000 title claims abstract 3
- 239000000203 mixture Substances 0.000 claims abstract 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M buffer Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 5
- 239000008363 phosphate buffer Substances 0.000 claims 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1
- GHCZTIFQWKKGSB-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;phosphoric acid Chemical compound OP(O)(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O GHCZTIFQWKKGSB-UHFFFAOYSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229940035504 Tromethamine Drugs 0.000 claims 1
- 239000008351 acetate buffer Substances 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 239000007979 citrate buffer Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 125000003372 histidine group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 230000002335 preservative Effects 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000000087 stabilizing Effects 0.000 claims 1
- 229960000281 trometamol Drugs 0.000 claims 1
- 230000002776 aggregation Effects 0.000 abstract 2
- 238000004220 aggregation Methods 0.000 abstract 2
- 239000000470 constituent Substances 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000006062 fragmentation reaction Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับองค์ประกอบที่เหมาะสมสำหรับโกนาโดโทรพิน การประดิษฐ์นี้จัดให้มี องค์ประกอบที่เป็นประโยชน์สำหรับการทำให้โกโดโทรพินเสถียรขณะที่ป้องกันการรวมกลุ่ม, การแตกตัว, การแตกระจาย และการสร้างสิ่งผันแปรของสปีชีส์ที่ถูกออกซิไดซ์ในสารละลายสำหรับการฉีด ดังนั้น มันจึงป้องกันความไม่เสถียรของโมเลกุลโปรตีนหรือโพลิเพปไทด์ที่มีสาเหตุอันเนื่องจากการรวมกลุ่ม หรือ การแตกกระจาย หรือการออกซิไดซ์ ระหว่างหรือหลังการกำหนดสูตรผสม เช่นกันมันจัดให้มีองค์ประกอบ ทางเภสัชกรรมของโกโดโทรพิน ซึ่งสามารถถูกใช้ทางการรักษาสำหรับการรักษาข้อบ่งชี้ต่างในรูปแบบ ขนาดยาเดียว หรือในรูปแบบหลายขนาดยา The invention involved a suitable composition for gonadotropin. This invention provides A useful constituent for stabilization of godotropin while preventing aggregation, disintegration, dispersion, and the generation of oxidized species in solution for injection. Hence, it prevents instability of protein molecules or polypeptides that are caused due to aggregation or fragmentation or oxidization. During or after formulation As well, it provides elements Pharmacy of Godotropin They can be used therapeutically for different indications in single-dose or multi-dose forms.
Claims (2)
Publications (3)
| Publication Number | Publication Date |
|---|---|
| TH167877B true TH167877B (en) | 2017-09-21 |
| TH1601002207A TH1601002207A (en) | 2017-09-21 |
| TH167877A TH167877A (en) | 2017-09-21 |
Family
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