TH166726A - Cyclic A Mic derivative used as an inhibitor of 11- beta-hydroxy steroid dehydrogenase and its use - Google Patents
Cyclic A Mic derivative used as an inhibitor of 11- beta-hydroxy steroid dehydrogenase and its useInfo
- Publication number
- TH166726A TH166726A TH1401003603A TH1401003603A TH166726A TH 166726 A TH166726 A TH 166726A TH 1401003603 A TH1401003603 A TH 1401003603A TH 1401003603 A TH1401003603 A TH 1401003603A TH 166726 A TH166726 A TH 166726A
- Authority
- TH
- Thailand
- Prior art keywords
- beta
- treatment
- compounds
- disorders
- conditions
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title claims abstract 5
- 102000004277 11-beta-Hydroxysteroid Dehydrogenases Human genes 0.000 title 1
- 108090000874 11-beta-Hydroxysteroid Dehydrogenases Proteins 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 8
- 201000010099 disease Diseases 0.000 claims abstract 8
- 208000001072 Type 2 Diabetes Mellitus Diseases 0.000 claims abstract 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims abstract 4
- 150000002632 lipids Chemical class 0.000 claims abstract 4
- 210000004369 Blood Anatomy 0.000 claims abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract 2
- 102000004190 Enzymes Human genes 0.000 claims abstract 2
- 108090000790 Enzymes Proteins 0.000 claims abstract 2
- 208000002705 Glucose Intolerance Diseases 0.000 claims abstract 2
- 206010020772 Hypertension Diseases 0.000 claims abstract 2
- 102000004877 Insulin Human genes 0.000 claims abstract 2
- 108090001061 Insulin Proteins 0.000 claims abstract 2
- 206010022489 Insulin resistance Diseases 0.000 claims abstract 2
- 208000008589 Obesity Diseases 0.000 claims abstract 2
- 102000004316 Oxidoreductases Human genes 0.000 claims abstract 2
- 108090000854 Oxidoreductases Proteins 0.000 claims abstract 2
- 230000002159 abnormal effect Effects 0.000 claims abstract 2
- 150000001408 amides Chemical class 0.000 claims abstract 2
- 239000008280 blood Substances 0.000 claims abstract 2
- 239000000306 component Substances 0.000 claims abstract 2
- 230000001419 dependent Effects 0.000 claims abstract 2
- 230000037213 diet Effects 0.000 claims abstract 2
- 235000005911 diet Nutrition 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drugs Drugs 0.000 claims abstract 2
- 235000020828 fasting Nutrition 0.000 claims abstract 2
- 239000008103 glucose Substances 0.000 claims abstract 2
- 230000001771 impaired Effects 0.000 claims abstract 2
- 235000020824 obesity Nutrition 0.000 claims abstract 2
- 239000005426 pharmaceutical component Substances 0.000 claims abstract 2
- 241000894007 species Species 0.000 claims abstract 2
Abstract
DC60 (20/06/57) การประดิษฐ์นี้เกี่ยวข้องกับอนุพันธ์เอไมด์บางชนิดที่มีความสามารถในการยับยั้ง 11-เบตา-ไฮดรอก ซีสเตียรอยด์ดีไฮโดรจีเนสชนิดที่ 1 (11เบตา-HSD-1) และซึ่งจึงเป็นประโยชน์ในการรักษาความผิดปกติบาง ชนิดที่สามารถได้รับการป้องกันหรือรักษาโดยการยับยั้งเอนไซม์นี้ได้ นอกจากนี้ การประดิษฐ์นี้ เกี่ยวข้องกับสารประกอบ วิธีการสำหรับการเตรียมสารประกอบดังกล่าว องค์ประกอบทางเภสัชกรรมที่มี ส่วนประกอบของสารประกอบดังกล่าว และการใช้สารประกอบเหล่านี้ในการรักษาความผิดปกติบางชนิด คาดว่า สารประกอบของการประดิษฐ์นี้จะสามารถใช้งานในการรักษาภาวะ เช่น เบาหวานชนิดที่ 2 แบบ ไม่พึ่งอินซูลิน (NIDDM) ภาวะต้านทานอินซูลิน โรคอ้วน ภาวะกลูโคสช่วงอดอาหารบกพร่อง ความทน ต่อกลูโคสบกพร่อง ความผิดปกติของลิพิด เช่น ภาวะสารไขมันในเลือดผิดปกติ ความดันเลือดสูง และ โรคและภาวะอื่น ๆ สิทธิบัตรยา DC60 (20/06/14) This invention involves some amide derivatives with inhibitory potential. 11- beta-hydroxyl C steroid dehydrogenase type 1 (beta 11-HSD-1) and thus useful in the treatment of some disorders. Species that can be prevented or treated by inhibiting this enzyme. Related to compounds Methods for the preparation of such compounds Available pharmaceutical components Components of the said compound And the use of these compounds in the treatment of certain disorders is expected to be used in the treatment of conditions such as type 2 diabetes mellitus non-insulin dependent (NIDDM), insulin resistance, obesity, fasting glucose, Impaired diet, impaired glucose tolerance. Lipid disorders, such as abnormal blood lipids Hypertension and other diseases and conditions, patent drug
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH166726A true TH166726A (en) | 2017-08-24 |
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