TH162099B - New insulin analogues and their uses - Google Patents
New insulin analogues and their usesInfo
- Publication number
- TH162099B TH162099B TH1501004860A TH1501004860A TH162099B TH 162099 B TH162099 B TH 162099B TH 1501004860 A TH1501004860 A TH 1501004860A TH 1501004860 A TH1501004860 A TH 1501004860A TH 162099 B TH162099 B TH 162099B
- Authority
- TH
- Thailand
- Prior art keywords
- insulin
- insulin analogues
- conjugate
- new insulin
- titer
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims abstract 17
- 102000004877 Insulin Human genes 0.000 claims abstract 5
- 108090001061 Insulin Proteins 0.000 claims abstract 5
- 102000003746 Insulin Receptor Human genes 0.000 claims abstract 2
- 108010001127 Insulin Receptor Proteins 0.000 claims abstract 2
- 239000004026 insulin derivative Substances 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000036499 Half live Effects 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 230000003247 decreasing Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับ อินซูอินอะนาล็อก (insulin analog) ที่มีอินซูลิน ไตเตอร์ (insulin titer) ลดลง และความสามาารถในการจับตัวรับอินซูลินลดลง เมื่อเทียบกับรูปแบบทั่วไปในธรรมชาติ (native form) สำหรับวัตถุประสงค์ในการเพิ่มค่าครึ่งชีวิตในเลือกของอินซูลิน, คอนจูเกต (conjugate) ถูกเตรียมขึ้น โดยการเชื่อมต่ออินซูลินอะนาล็อก (insulin analog) และตัวพา, สูตรตำรับที่ออกฤทธิ์นานนรวมถึงคอนจูเกต (conjugate), และวิธีการสำหรับการเตรียมคอนจูเกต (conjugate) This invention involves Insulin analogs with reduced insulin titer and decreased insulin receptor ability Compared with the native form for the purpose of increasing the selective half-life of insulin, the conjugate was prepared. By connecting insulin analogs and carriers, long-acting formulations including conjugates, and a method for preparing a conjugate.
Claims (3)
Publications (3)
Publication Number | Publication Date |
---|---|
TH1501004860A TH1501004860A (en) | 2017-04-27 |
TH162099A TH162099A (en) | 2017-04-27 |
TH162099B true TH162099B (en) | 2017-04-27 |
Family
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