TH158976A - 3-pyrimidin-4-il-oxasolidin-2-transfer. As a inhibitor of IDH mutants - Google Patents
3-pyrimidin-4-il-oxasolidin-2-transfer. As a inhibitor of IDH mutantsInfo
- Publication number
- TH158976A TH158976A TH1501005470A TH1501005470A TH158976A TH 158976 A TH158976 A TH 158976A TH 1501005470 A TH1501005470 A TH 1501005470A TH 1501005470 A TH1501005470 A TH 1501005470A TH 158976 A TH158976 A TH 158976A
- Authority
- TH
- Thailand
- Prior art keywords
- idh
- formula
- oxasolidin
- pyrimidin
- inhibitor
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 239000000126 substance Substances 0.000 claims abstract 3
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drugs Drugs 0.000 claims abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 1
- -1 C1-6 Lcoxy Chemical group 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract 3
- 101700024037 IDH1 Proteins 0.000 abstract 2
- 101700030371 IDH2 Proteins 0.000 abstract 2
- 102100002772 IDH2 Human genes 0.000 abstract 2
- 101710022949 icd Proteins 0.000 abstract 2
- 102000008300 Mutant Proteins Human genes 0.000 abstract 1
- 108010021466 Mutant Proteins Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
Abstract
การประดิษฐ์ได้มุ่งเน้นถึงสูตร (I) (สูตรเคมี) (I) หรือ เกลือที่สามารถยอมรับได้ทางเภสัชกรรมของสารนั้น ที่ซึ่ง R1, R2a, R2b, และ R3-R7 อยู่ใน ที่นี้ การประดิษฐ์ยังได้มุ่งเน้นถึงองค์ประกอบที่ประกอบด้วย สารประกอบของสูตร (I) และ การใช้ ของสารประกอบนั้นในการยับยั้งโปรตีน IDH กลายพันธุ์ ที่มีแอคทิวิตี้ของสัณฐานแบบใหม่ การประดิษฐ์ยังได้มุ่งเน้นถึงการใช้ของสารประกอบ (I) ในการบำบัดโรคหรือความผิดปกติที่เกิด ร่วมกับโปรตีน IDH กลายพันธุ์ ที่รวมถึง แต่ก็มิได้ถูกจำกัดเพียง ความผิดปกติในการเพิ่มจำนวน เซลล์ เช่นมะเร็ง สิทธิบัตรยา The invention focuses on the formula (I) (chemical formula) (I) or the pharmacologically acceptable salt of that substance, where R1, R2a, R2b, and R3-R7 are present. Composition Compounds of formula (I) and their use to inhibit the new amorphous IDH mutant protein. The invention also focused on the use of compound (I) in the treatment of diseases or disorders. Together with the IDH protein mutants including but not limited to Cell proliferation disorders, such as cancer, drug patent
Claims (1)
Publications (3)
| Publication Number | Publication Date |
|---|---|
| TH158976A true TH158976A (en) | 2017-01-04 |
| TH1501005470A TH1501005470A (en) | 2017-01-04 |
| TH158976B TH158976B (en) | 2017-01-04 |
Family
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