TH153753A - Quinoline derivatives as a PDE10A inhibitor - Google Patents
Quinoline derivatives as a PDE10A inhibitorInfo
- Publication number
- TH153753A TH153753A TH1401003608A TH1401003608A TH153753A TH 153753 A TH153753 A TH 153753A TH 1401003608 A TH1401003608 A TH 1401003608A TH 1401003608 A TH1401003608 A TH 1401003608A TH 153753 A TH153753 A TH 153753A
- Authority
- TH
- Thailand
- Prior art keywords
- provides
- compounds
- inhibitor
- quinoline derivatives
- pde10a inhibitor
- Prior art date
Links
- 102100017569 PDE10A Human genes 0.000 title claims abstract 3
- 101710031109 PDE10A Proteins 0.000 title claims abstract 3
- 239000003112 inhibitor Substances 0.000 title claims abstract 3
- 230000002401 inhibitory effect Effects 0.000 title claims abstract 3
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title claims abstract 3
- 229940093918 Quinoline gynecological antiinfectives Drugs 0.000 title 1
- 229940027991 antiseptics and disinfectants Quinoline derivatives Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 6
- 239000003814 drug Substances 0.000 claims abstract 4
- 102000004190 Enzymes Human genes 0.000 claims abstract 2
- 108090000790 Enzymes Proteins 0.000 claims abstract 2
- 206010053643 Neurodegenerative disease Diseases 0.000 claims abstract 2
- 229940079593 drugs Drugs 0.000 claims abstract 2
- 239000005426 pharmaceutical component Substances 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- 230000001225 therapeutic Effects 0.000 claims abstract 2
- 206010037175 Psychiatric disease Diseases 0.000 abstract 1
Abstract
DC60 (20/06/57) การประดิษฐ์นี้จัดให้มีอนุพันธ์ควิโนลีนของสูตร I ที่เป็นตัวยับยั้งเอนไซม์ PDE10A, และ ดังเช่นนั้นจึงเป็นประโยชน์ในการบำบัดความผิดปกติที่เกี่ยวกับระบบประสาทและจิตเวช โดยเฉพาะ อย่างยิ่ง, การประดิษฐ์จัดให้มีสารประกอบที่เฉพาะส่วนสูงสำหรับ PDE10 มากกว่าแบบชนิดย่อย PDE อื่นๆ การประดิษฐ์นี้ยังจัดให้มีองค์ประกอบทางเภสัชกรรมที่ประกอบรวมด้วยสารประกอบของ การประดิษฐ์ และวิธีการบำบัดความผิดปกติโดยการใช้สารประกอบของการประดิษฐ์ (สูตรเคมี) I สิทธิบัตรยา DC60 (20/06/14) This invention provides a quinoline derivative of Formula I as an inhibitor of the PDE10A enzyme, and thus is useful in the treatment of neurodegenerative and psychiatric disorders. More specifically, the invention provides a highly specialized compound for PDE10 than other PDE subtypes. The invention also provides a pharmaceutical component comprising fabricated compounds and therapeutics. Use of invention compounds (chemical formulas) I, drug patents.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH153753A true TH153753A (en) | 2016-06-30 |
| TH1401003608A TH1401003608A (en) | 2016-06-30 |
Family
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