TH152685A - Pyrolopyrimidine compounds and their applications - Google Patents
Pyrolopyrimidine compounds and their applicationsInfo
- Publication number
- TH152685A TH152685A TH901003793A TH0901003793A TH152685A TH 152685 A TH152685 A TH 152685A TH 901003793 A TH901003793 A TH 901003793A TH 0901003793 A TH0901003793 A TH 0901003793A TH 152685 A TH152685 A TH 152685A
- Authority
- TH
- Thailand
- Prior art keywords
- compounds
- need
- protein kinase
- treatment
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 9
- 102000001253 Protein Kinases Human genes 0.000 claims abstract 4
- 108060006633 Protein Kinases Proteins 0.000 claims abstract 4
- YQGHJCYLMLPCCB-UHFFFAOYSA-N 2,4-diaminopyrimidin-5-ol Chemical compound NC1=NC=C(O)C(N)=N1 YQGHJCYLMLPCCB-UHFFFAOYSA-N 0.000 claims abstract 2
- 206010003816 Autoimmune disease Diseases 0.000 claims abstract 2
- 102100019396 CDK2 Human genes 0.000 claims abstract 2
- 102100019398 CDK4 Human genes 0.000 claims abstract 2
- 101700008359 CDK4 Proteins 0.000 claims abstract 2
- 102100006129 CDK5 Human genes 0.000 claims abstract 2
- 101700001733 CDK5 Proteins 0.000 claims abstract 2
- 102100006130 CDK6 Human genes 0.000 claims abstract 2
- 102100006116 CDK7 Human genes 0.000 claims abstract 2
- 101700007872 CDK7 Proteins 0.000 claims abstract 2
- 102100003970 CDK8 Human genes 0.000 claims abstract 2
- 102100003972 CDK9 Human genes 0.000 claims abstract 2
- 101700049227 CDK9 Proteins 0.000 claims abstract 2
- 108010024986 Cyclin-Dependent Kinase 2 Proteins 0.000 claims abstract 2
- 108010025468 Cyclin-Dependent Kinase 6 Proteins 0.000 claims abstract 2
- 108010025415 Cyclin-Dependent Kinase 8 Proteins 0.000 claims abstract 2
- 201000009596 autoimmune hypersensitivity disease Diseases 0.000 claims abstract 2
- 201000011510 cancer Diseases 0.000 claims abstract 2
- 230000001276 controlling effect Effects 0.000 claims abstract 2
- 230000002596 correlated Effects 0.000 claims abstract 2
- 201000010099 disease Diseases 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drugs Drugs 0.000 claims abstract 2
- 230000000694 effects Effects 0.000 claims abstract 2
- 239000007943 implant Substances 0.000 claims abstract 2
- 230000002265 prevention Effects 0.000 claims abstract 2
- 238000002560 therapeutic procedure Methods 0.000 claims abstract 2
- QLGFTMMDEPUTTK-UHFFFAOYSA-N N,N-dimethylpyrimidine-4-carboxamide Chemical compound CN(C)C(=O)C1=CC=NC=N1 QLGFTMMDEPUTTK-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Abstract
DC60 (10/11/52) สารประกอบซึ่งถูกเปิดเผยเกี่ยวกับการรักษาและการบำบัดสำหรับความผิดปกติซึ่งสัมพันธ์กัน กับ-โปรตีนคิเนส มีความต้องการด้วยเช่นกันสำหรับสารประกอบที่เป็นประโยชน์ในการบำบัดหรือการ ป้องกันหรือการเยียวยาของหนึ่งหรือมากกว่าของกลุ่มอาการของมะเร็ง, การปฏิเสธสิ่งปลูกถ่าย, และ โรคภูมิคุ้มกันตนเอง นอกจากนั้น, มีความต้องการสำหรับวิธีสำหรับการคุมกิจกรรมของโปรตีนคิเนส, เช่น CDKI, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8, และ CDK9, โดยใช้สารประกอบซึ่งถูกจัด ให้มีในกรณีนี้ สิทธิบัตรยา DC60 (10/11/52) Compound, revealed treatment and therapy for correlated disorders. With - protein kinase There is also a need for beneficial compounds in the treatment or Prevention or remedies of one or more of cancer syndromes, implant rejection, and autoimmune disease.In addition, there is a need for methods for controlling the activity of protein kinase, such as CDKI, CDK2, CDK4, CDK5. , CDK6, CDK7, CDK8, and CDK9, using compounds that were To have in this case the patent for the drug
Claims (2)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH0901003793A TH0901003793A (en) | 2016-06-03 |
| TH152685A true TH152685A (en) | 2016-06-03 |
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