TH151426A - Rabies virus, mutants and vaccines - Google Patents

Abstract

DC60 (10/01/57) to provide a highly safe, effective, and inexpensive phobia vaccine. That has been prepared A mutated rabies virus (such as the ERA-N273 / 394- G333 strain shown in Figure 2) has at least one of the following mutations in a structural protein. Of the hydrophobia virus, ie, the mutation of residual amino acid at the -273 position in N protein to the remnant of the non-phenylalanine amino acid, the mutation of What's left of Amino acid at the -394 position in the N protein to the remnant of the non-tyrosine amino acid, and the residual mutation of the amino acid at the -333 position in the G protein to the Remaining of Non-arginine or lysine amino acids; Rabies vaccine preparations containing the malaria virus; And non-imports of amino acid residual mutations at position -333 in G protein induced attenuation of the virulence of the rabies virus, and the import of the mutations. Varieties of residues of amino acids at location-273. And the -394 position in N protein induced Improve the immunity and safety of the Rabophobia virus. In addition, the import of the Mutation of residual amino acids at position -273 And the -394 position in the N protein makes it possible to prevent an increase in the virulence of the Rabies virus, even when mutation of the Residuals of amino acids at the -194 position in the G protein to lysine are formed and, as a result, the possibility of the occurrence of a reversal of the pathogenesis of the hydrophobia virus caused by The The mutants can be degraded, and the safety of the hydrophobia virus can be further improved to provide a highly safe, effective and inexpensive solution for the Rabies. The information provided is: Mutant phobia virus (eg ERA-N273 / 394- G333 strain shown in Fig. 2) where at least one of the following mutations in a structural protein Of the hydrophobia virus, namely Mutation of residual amino acid at position -373 in N protein to residual of non-phenylalanine amino acid, residual mutation of Amino acid at the -394 position in the N protein to the remnant of the non-tyrosine amino acid and the residual mutation of the amino acid at the -333 position in the G protein to the Remaining of Non-arginine or lysine amino acids; Rabies vaccine preparations containing strains of water-phobia virus. Turns; and that is not The imports of amino acid residual mutations at the -333 position in the G protein induced attenuation of the virulence of the rabies virus, and the import of the mutations. Varieties of residues of amino acids at location-273. And the -394 position in N protein induced Improve the immunity and the safety of the Rabies Virus. In addition to that, import of the Mutation of residual amino acids at position -273 And the -394 position in the N protein makes it possible to prevent an increase in the virulence of the Rabies virus, even when mutation of the Residuals of amino acids at the -194 position in G protein to lysine are formed and, as a result, the The possibility of the occurrence of reversal of the pathogenesis of the hydrophobia virus, which is caused by Mutants can be mitigated and the safety of the Rabophobia virus can be further improved: drug patents.

Claims (2)

: DC60 (10/01/57) to provide a highly safe, effective and inexpensive phobia vaccine. As far as possible, this is: mutant phobia virus (such as the ERA-N273 / 394- G333 strain shown in Figure 2) which contains at least one of the following mutations in a structural protein. Of the hydrophobia virus, ie, the mutation of residual amino acid at the -273 position in N protein to the remnant of the non-phenylalanine amino acid, the mutation of What's left of Amino acid at the -394 position in the N protein to the remnant of the non-tyrosine amino acid, and the residual mutation of the amino acid at the -333 position in the G protein to the Remaining of Non-arginine or lysine amino acids; Rabies vaccine preparations containing the malaria virus; And non-imports of amino acid residual mutations at position -333 in G protein induced attenuation of the virulence of the rabies virus, and the import of the mutations. Varieties of residues of amino acids at location-273. And the -394 position in N protein induced Improve the immunity and safety of the Rabophobia virus. In addition, the import of the Mutation of residual amino acids at position -273 And the -394 position in the N protein makes it possible to prevent an increase in the virulence of the Rabies virus, even when mutation of the Residuals of amino acids at the -194 position in the G protein to lysine are formed and, as a result, the possibility of the occurrence of a reversal of the pathogenesis of the hydrophobia virus caused by The The mutants can be degraded, and the safety of the hydrophobia virus can be further improved to provide a highly safe, effective and inexpensive solution for the Rabies. The information provided is: Mutant phobia virus (eg ERA-N273 / 394- G333 strain shown in Fig. 2) where at least one of the following mutations in a structural protein Of the hydrophobia virus, namely Mutation of residual amino acid at position -373 in N protein to residual of non-phenylalanine amino acid, residual mutation of Amino acid at the -394 position in the N protein to the remnant of the non-tyrosine amino acid and the residual mutation of the amino acid at the -333 position in the G protein to the Remaining of Non-arginine or lysine amino acids; Rabies vaccine preparations containing strains of water-phobia virus. Turns; and that is not The imports of amino acid residual mutations at the -333 position in the G protein induced attenuation of the virulence of the hydrophobia, and the import of the mutations. Varieties of amino acid residues at location-273. And the -394 position in N protein induced Improve the immunity and safety of the Rabies virus. In addition to that, import of the Mutation of residual amino acids at position -273 And the -394 position in the N protein makes it possible to prevent an increase in the virulence of the Rabies virus, even when Residuals of amino acids at the -194 position in G protein to lysine are formed and, as a result, the The possibility of the occurrence of reversal of the pathogen of the hydrophobia virus caused by Mutants can be compromised and the safety of the Rabies virus can be improved. Next, the claim (Item one) which will appear on the advertisement page: edit 16/03/2015 1. The mutant water phobia virus Which includes at least the resin of the amino acids In addition to phenylalanine at position 273 in protein N, amino acid resin in addition to tyrosine at position 394 in protein N and amino acid necidus other than A. Marginine or lysine at position 333 in the G protein within the structural protein of the Rabies virus. 2. Rabies virus mutants according to claim No. 1 tagged: drug patent