TH150488A - Methods for preparation 4- amino-3-chloro-5-fluoro-6- (substitutated) picolinate - Google Patents
Methods for preparation 4- amino-3-chloro-5-fluoro-6- (substitutated) picolinateInfo
- Publication number
- TH150488A TH150488A TH1301004136A TH1301004136A TH150488A TH 150488 A TH150488 A TH 150488A TH 1301004136 A TH1301004136 A TH 1301004136A TH 1301004136 A TH1301004136 A TH 1301004136A TH 150488 A TH150488 A TH 150488A
- Authority
- TH
- Thailand
- Prior art keywords
- amino
- fluoro
- picolinate
- halogen
- steps involved
- Prior art date
Links
- SIOXPEMLGUPBBT-UHFFFAOYSA-M picolinate Chemical compound [O-]C(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-M 0.000 title claims abstract 4
- 238000000034 method Methods 0.000 title claims abstract 3
- 238000002360 preparation method Methods 0.000 title claims 2
- 230000032050 esterification Effects 0.000 claims abstract 4
- 238000005886 esterification reaction Methods 0.000 claims abstract 4
- 238000005658 halogenation reaction Methods 0.000 claims abstract 4
- 229910052751 metal Inorganic materials 0.000 claims abstract 4
- 239000002184 metal Substances 0.000 claims abstract 4
- 238000006243 chemical reaction Methods 0.000 claims abstract 3
- 229910052736 halogen Inorganic materials 0.000 claims abstract 3
- 150000002367 halogens Chemical class 0.000 claims abstract 3
- KFPBGJYBKSQIAI-UHFFFAOYSA-N 3,4,5,6-tetrachloropyridine-2-carbonitrile Chemical compound ClC1=NC(C#N)=C(Cl)C(Cl)=C1Cl KFPBGJYBKSQIAI-UHFFFAOYSA-N 0.000 claims abstract 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000005576 amination reaction Methods 0.000 claims abstract 2
- 230000008878 coupling Effects 0.000 claims abstract 2
- 238000010168 coupling process Methods 0.000 claims abstract 2
- 238000005859 coupling reaction Methods 0.000 claims abstract 2
- 229910052731 fluorine Inorganic materials 0.000 claims abstract 2
- 239000011737 fluorine Substances 0.000 claims abstract 2
- 230000026030 halogenation Effects 0.000 claims abstract 2
- 230000007062 hydrolysis Effects 0.000 claims abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 claims abstract 2
- 150000002739 metals Chemical class 0.000 claims abstract 2
- 238000010641 nitrile hydrolysis reaction Methods 0.000 claims abstract 2
- SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical class OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 claims abstract 2
- 230000007704 transition Effects 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000000758 substrate Substances 0.000 abstract 1
Abstract
DC60 (15/10/56) 4-อะมิโน-3-คลอโร-5-ฟลูออโร-6- (ซับสติติวเตด) พิโคลิเนตถูกเตรียมขึ้นได้อย่างสะดวกจาก 3,4,5,6-เตตระคลอโรพิโคลิโนไนไทรล์ ด้วยขั้นตอนชุดหนึ่งซึ่งเกี่ยวพันกับการเเลกเปลี่ยนฟลูออรีน, อะมิเนชั่น, การเเลกเปลี่ยนฮาโลเจน และ ไฮโดรไลซิส, เอสเทอริฟิเคชัน และ การคัปปลิ้งที่มีโลหะ ทรานสิชันช่วย 4-อะมิโน-5-ฟลูออโร-5-ฮาโล-6-(ซับสทิทิวเทด)พิโคลิเนตส์ถูกเตรียมอย่างสะดวกจาก 3,4,5,6-ไตรคลอโรพิโคลิโนไตร์ล ด้วยลำดับของขั้นตอนที่เกี่ยวข้องกับการเเลกเปลี่ยนฟลูออรี อะมิเนชั่น การเเลกเปลี่ยนฮาโลเจน ฮาโลเจน ฮาโลจิเนชั่น ไนไตร์ลไฮโดรไลซิส เอสเทอริฟิเคชั่น เเละการ ดับบลิงที่ถูกช่วยเหลือจากโลหะทรานซิซั่น DC60 (15/10/56) 4-amino-3-chloro-5-fluoro-6- (substrate) picolinate was conveniently prepared from 3,4,5,6-tetrachloropicolinonitrile There is a series of steps involved in fluorine conversion, amination, halogen and hydrolysis, esterification and coupling. metal Transitions help 4- amino-5-fluoro-5-halo-6- (substituteed) picolinates were conveniently prepared from 3,4,5,6-trichloropycolinotyral The sequence of steps involved in fluorization conversion, halogen-halogenation, halogenation, nitrile hydrolysis, was used for the process. Esterification and dubbing rescued from transitional metals
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH150488A true TH150488A (en) | 2016-03-14 |
Family
ID=
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112013018975A2 (en) | Process for the preparation of 4-amino-5-fluoro-3-halo-6- (substituted) picolinates | |
| UA109806C2 (en) | METHOD OF OBTAINING 4-AMINO-5-FLUORO-3-HALOGEN-6- (SUBSTITUTED) PICOLINATES | |
| BR112013019025A2 (en) | Process for the preparation of 4-amino-3-chloro-5-fluoro-6- (substituted) picolinates | |
| MX2013008604A (en) | Process for the preparation of 4-amino-3-chloro-5-fluoro-6-(subst ituted)picolinates. | |
| BR112016031007B8 (en) | INTERMEDIARIES FOR THE PREPARATION OF 4-ALKOXY-3- HYDROXYPICOLINIC ACIDS | |
| PL397479A1 (en) | New, fluorescent heterocyclic dyes and a process for their manufacturing | |
| TH150488A (en) | Methods for preparation 4- amino-3-chloro-5-fluoro-6- (substitutated) picolinate | |
| TH141685A (en) | Methods for preparation 4- amino-5-fluoro-halo-6- (substitutated) picolinate | |
| TH141686A (en) | Methods for preparation 4- amino-5-fluoro-halo-6- (substitutated) picolinate | |
| TH141683A (en) | Methods for preparation 4- amino-3-chloro-5-fluoro-6- (substitutated) picolinate | |
| BR112018014763A2 (en) | process for the preparation of 4-alkoxy-3-hydroxypicolinic acids | |
| EP4365267A3 (en) | Fluorinated diester compounds and their use in heat transfer system | |
| HK1189125A (en) | Process for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates | |
| TH112927A (en) | Salt is used for cooking and other products. Of salt for cooking | |
| HK1189124A (en) | Process for the preparation of 4-amino-3-chloro-5-fluoro-6-(substituted)picolinates | |
| TH156232A (en) | Method of production of the derivative 4,4-difluoro-3,4-dihydroisocquinoline | |
| Kemalov et al. | INVOLVEMENT OF HEAVY PITCHES OF RAW MATERIALS PYROLYSIS IN PRODUCTION OF water-BITUMen EMULSIONS | |
| TH170789A (en) | Process for the preparation of 4-Loxin-3-Hydroxipicolinic Acid | |
| TH160640A (en) | 4- amino-6- (4-substrate-phenyl) -picolinate and 6-amino-2- (4-substrate-phenyl) - Pyrimidine-4-carboxylate And the use of those substances as herbicides | |
| TH156194A (en) | Benzoic acid derivatives | |
| TH170788A (en) | Process for acid preparation 4-Loxin-3-Hydroxypicholinic | |
| TH132745A (en) | Useful amidofoxiindesole is an inhibitor of C-MET. | |
| TH1701002555A (en) | 2- amino-6- (diffuoromethyl) -5,5-diffluoro-6-phenyl -3,4,5,6-tetra hydropyridine A Is a BACE1 inhibitor | |
| TH151589A (en) | A new method for preparing the compound by Michael's addition reaction using water or various acids as additives. | |
| TH154970A (en) | Aca indolene |