TH147151A

TH147151A - Triazolopyridine compounds are PIM kinase inhibitors.

Info

Publication number: TH147151A
Application number: TH1301004736A
Authority: TH
Inventors: อี โรรินสัน นายจอห์น; เอฟ เบลค นายเจมส์; เอ็ม เกรแฮม นายเจมส์; หวัง นายบิน; ไลออน นายไมเคิล; ซู นายริว; เคิร์ก เดลิเซิล นายโรเบิร์ต; เอ เด มีเซ่ นายลิซ่า; เลอ ฮูโร นายวาน; เอ็ม วอลเลซ นายเอลิ
Original assignee: นางดารานีย์ วัจนะวุฒิวงศ์; นางสาวสนธยา สังขพงศ์; แอร์เรย์ ไบโอฟาร์มา อิงค์
Filing date: 2012-02-24
Publication date: 2016-03-04

Abstract

DC60 (26/08/56) สารประกอบที่มีสูตรโครงสร้างที่ I ซึ่ง R1, R2, R3, R4 และ R10 มีความหมายที่ให้ไว้ใน รายละเอียดการประดิษฐ์ คือ สารยับยั้งรีเซพเตอร์ไทโรซีนที่เป็นประโยชน์ในการรักษาโรคต่างๆ ที่มี PIM-1 และ/หรือ PIM-2 และ/หรือ PIM-3 ไคเนสเป็นสื่อกลางDC60 (26/08/56) A compound with structural formula I, where R1, R2, R3, R4 and R10 have the meanings given in the invention description, is a tyrosine receptor inhibitor with therapeutic efficacy in various diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases.

Claims

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1. A type of compound with a general structural formula at I (chemical formula) and stereoisomers; pharmaceutically acceptable salts and substances formed from the reaction of various solvents and solutes. Of the compounds mentioned, where R1 is H, halogen, CN, OH, (1-6C)alkyl, fluoro(1-6C)alkyl, difluoro(1-6C)alkyl, trifluoro(1-6C)alkyl, hydroxy(1-6C)alkyl, cyano(1-6C)alkyl, (1-3C alkoxy)(1-C6)alkyl (with alternative hydroxy substitution), di(1-3C alkoxy)(1-6C)alkyl, (1-6C)alkoxy, fluoro(1-6C)alkoxy, difluoro(1-6C)alkoxy, trifluoro(1-6C)alkoxy, hydroxy(2-C6)alkoxy, cyano(1-6C)alkoxy, (1-3C (2-6C)alkoxy, di(1-3C alkoxy), (2-6C)alkoxy, (3-6C cycloalkyl)methoxy, oxetanylmethoxy (with alternative substitution of methyl), (1-6C alkyl)sulfanyl, -C(=O)NRaRb,-CH2C(=O)NRcRd or (3-6C)cycloalkyl with Alternatively, -CH2OH or -CH2O(1-4C alkyl) Ra, Rb, Rc, and Rd are independently selected groups derived from H and (1-4C)alkyl. R2 is H, halogen, CN, OH, (1-6C)alkyl, fluoro(1-6C)alkyl, difluoro(1-6)alkyl, trifluoro(1-6C)alkyl, hydroxya(1-6C)alkyl, (1-3C alkoxy)(1-6C)alkyl, (1-6)alkoxy. (Alternative substitutions include (1-6C alkyl)C(=O)O-, amino(1-6C alkyl)C(=O)O-, or phenyl (C=O)O-), fluoro(1-6C)alkoxy, difluoro(1-6C)alkoxy, trifluoro(1-6C)alkoxy, hydroxy(2-6C)alkoxy, (1-3C alkoxy)(2-6C)alkoxy, (3-6C cycloalkyl)methoxy, (3-6C)cycloabxoxy (with alternative substitution by OH), oxetanylmethoxy (with alternative substitution by methyl), tetrahydropyranyloxy, (1-6C alkyl)sulfanyl, hydroxy(2-6C Alkyl)sulfanil, (1-3C alkylsulfanil)(2-6C)alkoxy, -COOH, hetAr1, -C(-O)NReRf,-NReC(=O)Rf, oxetanil or cyclopropyl with alternative substitution by -CH2OH or -CH2O(1-6C alkyl) or R1 and R2 when attached to the atom to which the group is attached. A 5-6 polygonal heterocyclic ring is constructed with one or two heterogeneous atoms in the ring, independently selected from O and N, where the ring is alternatively substituted with (1-4C) alkyl alkyls. Ar1 is a 5-6 polygonal heterocyclic ring with one or two nitrogen atoms in the ring, and is alternatively substituted with one or more groups chosen from (1-6C) alkyls. Re and Rf are H, (1-6C) alkyls, or cyclopropyls, which are alternatively substituted with (1-4C) alkyls independently. R3 is H, a halogen, or (1-6C) alkyls. R4 is R5 is CF3, CH2F, CHF2, methyl, or ethyl. R5a is H or methyl, or R5 and R5a when attached to the atom to which the group is attached. A cyclopropyl ring is formed. R6 is H, NH2, OH, (1-6C alkyl)NH-, fluoro(1-6C alkyl)NH, hydroxy(1-6C alkyl)NH-, (3-6C cycloalkyl)CH-NH-, (1-6C alkyl)C(=O)NH, (1-6C alkyl)OC(=O)NH- (with alternative substitution of 5-methyl-2-oxo-1,3-dioxol-4-yl) or amino(1-6C)alkyl-. R7 is H, (1-6C)alkyl, fluoro(1-6C)alkyl, or hydroxy(1-6C)alkyl, or R6 and R7 when attached to the atom to which these groups are attached. A 5-6 polygonal spiralcyclic heterocycle is formed with a nitrogen atom in one of the atomic rings. R8 is H, a halogen, OH, or (1-6C)alxoxy, or R6 and R8 when connected to the carbon atom to which the group is attached. A cyclopropyl ring is formed with an alternative substitution of NH2. R9 is H, or R6 and R9 when connected. A linking group with the structural formula -CH2NH- is formed, which connects the carbon atom to which the group is attached, and R10 is H or a halogen.

2. A compound according to claim 1, where R1 is H, halogen, CN, OH, (1-6C)alkyl, fluoro(1-6C)alkyl, difluoro(1-6C)alkyl, trifluoro(1-6C)alkyl, hydroxy(1-6C)alkyl, cyano(1-6C)alkyl, (1-3C alkoxy)(1-6C)alkyl (with alternative hydroxy substitution), di(1-3C alkoxy)(1-6C)alkyl, (1-6C)alkoxy, fluoro(1-6C)alkoxy, difluoro(1-6C)alkoxy, trifluoro(1-6C)alkoxy, hydroxy(2-6C)alkoxy, cyano(1-6C)alkoxy, (1-3C alkoxy)(2-6C)alkoxy, di(1-3C alkoxy)(2-6C)alkoxy, (3-6C cycloalkyl)methoxy, oxetanylmethoxy (with alternative substitution by methyl), (1-6C alkyl)sulfanyl, -C(=O)NRaRb,-CH2C(=O)NRcRd or (3-6C)cycloal with Alternative substitution with -CH2OH or -CH2O(1-4C alkyl). Ra, Rb, Rc and Rd are independently selected groups from H and (1-4C)alkyl. R2 is H, halogen, CN, OH.(1-6C)alkyl, fluoro(1-6C)alkyl, difluoro(1-6)alkyl, trifluoro(1-6C)alkyl, hydroxy(1-6C)alkyl, (1-3C alkoxy)(1-6C)alkyl, (1-6C)alkoxy (with alternative substitution with (1-6C alkyl)C(=O)O- or amino(1-6C). (Alkyl)C(=O)O-), fluoro(1-6C)alkoxy, difluoro(1-6C)alkoxy, trifluoro(1-6C)alkoxy, hydroxya(2-6C)alkoxy, (1-3C alkoxy)(2-6C)alkoxy, (3-6C cycloalkyl)methoxy, oxetanylmethoxy (with substitution) Alternatively substituted with methyl), tetrahydropyranyloxy, (1-6C alkyl)sulfanil, hydroxy(2-6C alkyl)sulfanil, (1-3C alkylsulfanil)(2-6C)alxoxy, -COOH, hetAr1, C(=O)NReRf, -NReC(=O)Rf, or cyclopropyl with alternative substitution of -CH2OH or -CH2O(1-6C alkyl) or R1 and R2 when attached to the atom to which the group is attached. A 5-6 polygonal heterocyclic ring is constructed with one or two heterogeneous atoms in the ring, independently selected from O and N, where the ring is alternatively substituted with (1-4C) alkyl atoms. Ar1 is a 5-6 polygonal heterocyclic ring with one or two nitrogen atoms in the ring, and is alternatively substituted with one or more groups chosen from (1-6C) alkyl atoms. Re and Rf are H, (1-6C) alkyl or cyclopropyl atoms that are independently substituted with (1-4C) alkyl atoms. R3 is H, a halogen, or (1-6C) alkyl atom. R4 is (chemical formula). R5 is CF3, CH+F, CHFz, methyl, or ethyl. R5a is H or methyl, or R5 and R5a when attached to the atom to which the group is attached. A cyclopropyl ring is formed. R6 is H, -NH2, OH, (1-6C alkyl)NH-, fluoro(1-6C alkyl)NH-, hydroxy(1-6C alkyl)NH-, (3-6C cycloallyl)CH2NH-, (1-6C alkyl)C(=O)NH, (1-6C alkyl)OC(=O)NH-, or amino(1-6C)alkyl-. R7 is H, (1-6C)alkyl, fluoro(1-6C)alkyl, or hydroxy(1-6C)alkyl, or R6 and R7 when attached to an atom to which the group is attached. A 5-6 polygonal spiralcyclic heterocycle is formed with a nitrogen atom in one of the atomic rings. R8 is H, halogen, OH, or (1-6C)alxoxy, or R6 and R8 when connected to the carbon atom to which the group is attached. A cyclopropyl ring is formed with an alternative substitution of NH2. R9 is H, or R6 and R9 when connected. A linking group with the structural formula -CH2NH- is formed, which connects the carbon atom to which the group is attached, and R10 is H.

3. A compound of claim 1 or 2, where R1 is a selected group of H, (1-6C)alkyl, (3-6C)cycloalkyl with alternative substitution of -CH2OH or -CH2O(1-4C alkyl), (1-6C)alkoxy, trifluoro(1-6C)alkoxy, hydroxy(2-6C)alkoxy, (1-3C alkoxy)(2-6C)alkoxy and (3-6C)cycloalkylmethoxy.

4. A compound of claim III where R1 is a chosen group from H, methyl, ethyl, isopropyl, tertiary-butyl, cyclopropyl, methoxy, ethoxy, isopropoxy, trifluoromethoxy, 2-hydroxyethoxy, 2-hydroxypropoxy, 3-hydroxypropoxy, 2-methoxyethoxy, 3-methoxypropoxy, 2-methoxypropoxy, 3-methoxyprop-2-oxy, 2-ethoxyethoxy, 1,3-dimethoxypropan-2-yloxy and cyclopropylmethoxy.

5. A compound of claim number 4, where R1 is H.

6. A compound of claim 4 where R1 is (1-3C alkoxy)(2-6C)alkoxy.

7. A compound of claim I, where R1 is the selected halogen group, CN, OH, fluoro(1-6C)alkyl, difluoro(1-6C)alkyl, trifluoro(1-6C)alkyl, hydroxy(1-6C)alkyl, cyano(1-6C)alkyl, di(1-3C alkoxy)(1-6C)alkyl, fluoro(1-6C)alkoxy, difluoro(1-6C)alkoxy, trifluoro(1-6C)alkoxy, cyano(1-6C)alkoxy, di(1-3C alkoxy)(2-6C)alkoxy, oxetanylmethoxy. (with alternative substitution with methyl), (1-6C alkyl)sulfanyl, -C(=O)NRaRb and -CH-C(=O)NRcRd

8. A compound according to one of the claims 1-7, where R2 is a selected group of H, (1-3C alkoxy)(1-6C)alkyl, hydroxy(2-6C)alkoxy and (1-6C)alkoxy which is alternatively substituted by (1-6C alkyl)C(=O)O- or amino(1-6C alkyl)C(=O)O-.

9. A compound according to claim number 8, where R2 is a selected group from H, 2-methoxyethoxy, 3-methoxyprop-2-oxy, 2-methoxypropoxy, 2-ethoxyethoxy and 2-hydroxyethoxy.

10. A compound according to claim number 9, where R2 is H.

11. A compound according to one of the claims 1-7, where R2 is the selected group from the halogen, CN, OH, (1-6C)alkyl, fluoro(1-6C)alkyl, difluoro(1-6C)alkyl, trifluoro(1-6C)alkyl, hydroxy(1-6C)alkyl, fluoro(1-6C)alkoxy, difluoro(1-6C)alkoxy, trifluoro(1-6C)alkoxy, (1-3C alkoxy)(2-6C)alkoxy, (3-6C cycloalkyl)methoxy, oxethanylmethoxy (with alternative substitution by methyl), tetrahydropyranyloxy, (1-6C alkyl)sulfanyl, hydroxy(2-6C Alkyl)sulfanil, (1-3C alkylsulfanil)(2-6C)aloxy, -COOH, hethAr1, -C(=O)NReRf, -NReC(-O)Rf and cyclopropyl with alternative substitution of -CH2OH or -CH2O(1-6C alkyl).

12. A compound of the nature of claim 1 or 2 such that R1 and R2, when attached to the atoms of the said group, form a 5-6 polygonal heterocyclic ring containing 1 to 2 heterogeneous atoms in the ring, independently selected from O and N, in which the ring is alternatively replaced by (1-4C)alkyl atoms.

13. A compound that meets one of the claims from clauses 1-12, where R3 is a chosen group from H, F, and methyl.

14. A compound according to claim 13, where R3 is H.

15. A compound according to claim 13, where R3 is F.

16. A compound according to one of the claims from clauses 1-15, where R5 is CF3, CH2F, CHF2, methyl or ethyl, and R5a is H.

17. A compound according to claim 16, where R5 is CF3 and R5a is H.

18. A compound according to one of the claims from clauses 1-15, where R85 is CF3, CH2F, CHF2, methyl or ethyl and R5a is methyl.

19. A compound according to claim 15, where R5 is methyl and R5a is H.

20. A compound that meets one of the claims from clauses 1-19, where R6 is a chosen group from H, NH2, OH, CH3NH-, (CH3)CHNH-, FCH2CH2NH-, HOCH2CH2NH-, (cyclopropyl)CH2NH-, CH3C(=O)NH-, (CH3)3COC(=O)NH- and NH2CH2.

21. A compound according to claim 20, where R6 is NH2.

22. A compound that meets one of the claims from clauses 1-21, where R7 is a selected group from H, methyl, ethyl, FCH2-, and HOCH2-.

23. A compound according to claim 22, where R7 is H.

24. A compound according to claim 23, where R7 is methyl.

25. A compound, according to one of the claims from 1-19, such that R6 and R7, when attached to the atoms to which they are bound, form a 5-6 sided spirocyclic heterocyclic ring containing a nitrogen atom in one of the atomic rings.

26. A compound that aligns with one of the claims from clauses 1-25, where R8 is a chosen group from H, F, OH, or -OMe.

27. A compound according to claim 26, where R8 is H.

28. A compound, according to one of the claims from clauses 1-19, is formed where R6 and R9, when attached to the carbon atom to which the group is attached, form a cyclopropyl ring with alternative substitution by NH2.

29. A compound that meets one of the claims from clauses 1-28, where R9 is H.

30. A compound is formed according to one of the claims from clauses 1-19 such that when R6 and R9 are joined together, they form a linking group with the structural formula -CH2NH- which connects the carbon atom to which this group is attached.

31. A compound that meets one of the claims from clauses 1-30, where R10 is H.

32. A compound according to one of the claims from clauses 1 or 3-30, where R10 is a fluorocarbon.

33. A compound of claim I, chosen from among the following compounds: (3S)-1-(2,2,2-trifluoro-1-(3-(8-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolilin-3-amine hydrochloride; (3S)-1-(1-(3-(7-bromoquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrolidim-3-amine trihydrochloride. (3S)-1-(1-(3-(7-cyclopropylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride (3S)-1-(2,2,2-trifluoro-1-(3-(7-(1-methyl-1H-pyrazol-4-il)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine trihydrochloride (3S)-1-(1-(3-(8-(cyclopropylmethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride 8-methoxy-2-(6-(2,2,2-trifluoro-1-(pyrrolidin-1-il)ethyl)-[1,2,4]triazolo [4,3-a]pyridin-3-il)quinolin (3S)-1-(2,2,2-trifluoro-1-(3-(8-methoxyquinolin-2-il)-[1,2,4]triazolo [4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-ol (s)-1-((s)-2,2,2-trifluoro-1-(3-(8-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (s)-1-((r)-2,2,2-trifluoro-1-(3-(8-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,22,-trifluoro-1-(3-(8-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)le)pyrrolidin-3-amine dihydrochloride (S)-1-(S)-1-(3-(8-(cyclopropylmethoxy)quinolin-2-il)-[1,2,4]triazolo [4.3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-1-(3-(8-(cyclopropylmethoxy)quinolin-2-il)-[1,2,4]triazolo [4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrolidin-3-amine dihydrochloride (S)-1-(S)-1-(3-(7-cyclopropylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrolidin-3-amine (S)-1-(R)-1-(3-(7-cyclopropylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrolidin-3-amine (S)-1-((S)-2,2,2-trifluoro-1-(3-(7-(1-methyl-1H-pyrazol-4-il)quinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)ethyl)pyrrolidin-3-amine tri-hydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-(1-methyl-1H-pyrazol-4-il)quinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)ethyl)pyrrolidin-3-amine tri-hydrochloride (3R)-1-(1-(3-(8-(cyclopropylmethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride (3S)-1-(1-(3-(8-tertiary-butylquinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)ethyl)pyrrolidin-3-amine trihydrochloride (3S)-1-(2,2,2-trifluoro-1-(3-(7-(pyridin-3-il)quinolin-2-il)-[1,2,4]triazoloethyl Solo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3-amine trihydrochloride (3S,4S)-1-(2,2,2-trifluoro-1-(3-(8-methoxyquinolin-2-il)-[1,2,4]tria Solo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3,4-diol (3S)-1-(1-(3-(8-(cyclopropylmethoxy)quinolin-2-il)-[1,2,4]tria Solo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)-n-methylpyrolidin-3-amine trihydrochloride ((3R)-1-(1-(3-(8-(cyclopropylmethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-il)methanamine dihydrochloride (R)-1-((R)-1-(3-(8-(cyclopropylmethoxy)quinolin-2-il)-[1,2,4]triazolo [4,3-A]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidim-3-amine (R)-1-((S)-1-(3-(8-(cyclopropylmethoxy)quinolin-2-il)-[1,2,4]triazolo [4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine ((3s)-1-(1-(3-(8-(cyclopropylmethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-il)methanamine dihydrochloride 2-(6-(1-((1r,4r)-2,5-diazabicyclo[2.2.1]heptan-2-il)-2,2,2-trifluoroethyl (1,2,4]triazolo[4,3-a]pyridin-3-il)-8-(cyclopropylmethoxy)quinoline dihydrochloride (1R,5S,6S)-3-(1-(3-(8-(cyclopropylmethoxy)quinoline-2-il)-[1,2,4]triazolo[4,3-a]pyrikim-6-il)-2,2,2-trifuaroethyl)-3-azabicyclo[3.1.0]hexenzan-6-amine dihydrochloride 1-(1-(3-(8-(cyclopropylmethoxy)quinoline-2-il)-[1,2,4]triazolo[4,3-a]pyri (3S)-1-(2,2,2-trifluoroethyl)-3-methylpyrolidin-3-amine dihydrochloride 2-(6-(1-(3-amino-3-methylpyrolidin-1-yl)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyrikim-3-yl)quinolin-8-ol hydrochloride (3S)-1-(2,2,2-trofluoro-1-(3-(7-(trifluoromethyl)quinolin-2-yl)- [1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrolikin-3-amine dihydrochloride 2-(6-(1-((S)-3-aminopyrolikin-1-yl)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-N-isopropylquinoline-7-carboxamide dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinoline-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrolidin-3-amine dihydrochloride (3S)-1-(1-(3-(8-(cyclopropylmethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)-n-isopropylpyrrolidin-3-amine dihydrochloride (3S)-1-(1-(3-(8-(R)-1-methoxypropan-2-iloxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine trihydrochloride 2-(6-(R)-1-((S)-3-aminopyrrolidin-1-yl)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-yl)-N-isopropylquinoline-7-carboxamide dihydrochloride 2-(6((R)-(1S)-3-aminopyrrolidin-1-yl)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-yl)-N,N-dimethylquinoline-7-carboxamide dihydrochloride (S)-N-methyl-1-((S)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinoline-2- (1,2,4)triazolo[4,3-a]pyridin-6- (1,2,4)ethyl)pyrolikin-3-amine dihydrochloride (S)-1-((R)-1-(3-(8-ethylquinolin-2- (1,2,4)triazolo[4,3-a]pyridin-6- (1,2,2)-trifluoroethyl)pyrolidin-3-amine hydrochloride 2-(6-((R)-1-((S)-3-aminopyrolidin-1- (1,2,2)-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridim-3- (1,2,4)-n-ethylquinolin-7-carboxamide hydrochloride (S)-1-((R)-1-(3-(8-cyclopropylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-(trifluoromethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-isopropylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride 2-(6-(R)-1-((S)-3-aminopyrrolidin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)-n-methylquinolin-7-carboxamide dihydrochloride (S)-1-((R)-1-(3-(8-(cyclopropylmethoxy)quinolin-2-il)-[1,2,4]triazolo [4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)-m-methylpyrolidin-3-amine dihydrochloride N-(2-(6-(1-((S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-il)quinolin-7-il)isobutyramide (S)-1-((R)-1-(3-(8-tertiary-butylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrolidin-3-amine dihydrochloride 2-(6-((R)-1-((S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)-n-tertiary-butylquinoline-7-carboxamyl dihydrochloride (R)-1-((R)-1-(3-(8-cyclopropylquinoline-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrolidin-3-amine dihydrochloride 2-(6-((s)-1-((s)-3-aminopyrolidin-1-yl)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-yl)-n-isopropylquinoline-7-carboxamide dihydrochloride 2-(6-((r)-1-((r)-3-aminopyrolidin-1-yl)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-yl)-n-isopropylquinoline-7-carboxamide dihydrochloride N-((3S)-1-(1-(3-(8-(cyclopropylmethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrolidin-3-)acetamide (S)-1-((S)-1-(3-(8-cyclopropylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrolidin-3-amine dihydrochloride 2-(6-(s)-1-1-(r)-3-aminopyrolidin-1-yl)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-n-isopropylquinoline-7-carboxamide 2-(6-((R)-1-((S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)-N-(1-methylcyclopropyl)quinoline-7-carboxamide dihydrochloride 2-(6-((R)-1-((R)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)-N-tertiary-butylquinoline-7-carboxamide dihydrochloride 2-(6-((R)-1-((R)-3-aminopyrolikin-I-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)-N-(1-methylcyclopropyl)quinoline-7-carboxamide dihydrochloride (R)-1-((S)-1-(3-(8-cyclopropylquinoline-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrolidin-3-amine N-isopropyl-2-(6-((R)-2,2,2-trifluoro-1-((S)-3-(methylamino)pyrolikin Din-1-il)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)quinoline-7-carboxamide N N-tertiary-butyl-2-(6-((R)-2,2,2-trifluoro-1-(S)-3-(methylamino) Pyrrolidin-1-il)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)quinoline-7-carboxamide 2-(6-((R)-1-((R)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)-n-tertiary-pentylquinoline-7-carboxamide dihydrochloride (S)-1-(R)-1-(3-(8-cyclopropyl-7-fluoroquinoline-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrolidin-3-amine dihydrochloride (R)-1-(R)-1-(3-(7-cyclopropylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride 2-(6-((R)-1-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)-8-tertiary-butylquinolin 2-(6-((R)-1-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-7-fluoroquinoline dihydrochloride 2-(6-((R)-1-((1S,4S)-2,5-diazabicyclo[2.2.1]]heptan-2-yl)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-7-chloroquinoline dihydrochloride 2-(6-(R)-1-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-8-cydolpropylquinoline dihydrochloride 2-(6-((R)-1-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-8-ethylquinoline dihydrochloride 2-(6-((R)-1-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-A]pyridin-3-il)-8-(cyclopropylmethoxy)quinoline dihydrochloride 2-(6-((R)-1-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-A]pyridin-3-il)-7-bromoquinoline dihydrochloride (S)-1-((R)-1-(3-(7-cyclopropyl-8-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride N-(2-(6-((R)-1-((S)-3-aminopyrrolidin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)quinolin-7-il)isobutyramide N-(2-(6-((R)-1-((S)-3-aminopyrrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-il)twinolin-7-il)pyvalamide (3R,4R)-1-((R)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinolin-2-il)- [1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3,4-diol (3R,4R)-1-((R)-1-(3-(8-ethylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin (3R,4R)-2,2,2-trifluoroethyl)pyrrolidine-3,4-diol (3R,4R)-1-((R)-1-(3-(8-tertiary-butyl vinol-2-il)-[1,2,4]triazolo [4,3-a]pyridine-6-il)-2,2,2-trifluoroethyl)pyrrolidine-3,4-diol 2-(6-((R)-1-((S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-A]pyridin-3-il)-8-sopropoxyquinoline-7-carbonitrile dihydrochloride 2-(6-((S)-1-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-il)-2,2,2-tri Fluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)-8-(cyclopropylmethoxy)quinoline dihydrochloride 2-(6-((s)-1-1-(1s,4s)-2,5-diazabicyclo[2.2.1]heptan-2-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)-7-cyclopropylquinoline dihydrochloride (3r,4r)-1-((r)-1-(3-(8-cyclopylquinoline-2-il)-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-2,2,2-trifluoroethyl)pyrolidin-3,4-diol (S)-1-((R)-1-(3-(8-ectoxyquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-2,2,2-trifluoroethyl)pyrolikin-3-amine (S)-N-(2-fluoroethyl)-1-((R)-2,2,2-trifluoro-1-(3-(8-methoxyquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrolidin-3-amine dihydrochloride (3R,4R)-1-((S)-2,2,2-Trifluoro-1-(3-(8-isopropoxyquinolin-2-il)-[1,2,4]Triazolo[4,3-A]pyridin-6-il)ethyl)pyrrolidine-3-amine chihydrochloride (3R,4R)-1-((S)-2,2-Trifluoro-1-(3-(8-isopropoxyquinolin-2-il)-[1,2,4]Triazolo[4,3-A]pyridin-6-il)ethyl)pyrrolidine-3,4-diol 2-(6-(R)-1-((S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-A]pyridim-3-il)-tertiary-butyl-8-cyclopropylquinoline-7-carboxamide dihydrochloride 2-(6-((R)-1-((S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-pyridin-3-il)quinoline-7-carbotrile acid 2-(6-((S)-1-((R)-3-(tortieri-butoxycarbonylamino)pyrolidin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-A]pyridin-3-il)quinoline-7-carboxylic acid (S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-8-isopropoxyquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrolidin-3-amine hydrochloride 2-(6-(R)-1-((S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-il)-N-isopropylquinoline-8-carboxamide dihydrochloride 2-(6-((R)-1-((S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-il)quinoline-8-carbonitrile dihydrochloride 2- (6-(R)-1-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-A]pyridin-3-yl)quinoline-8-carbonitrile dihydrochloride (R)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinoline-2-yl)- [1,2,4]triazolo[4,3-A]pyridin-6-yl)ethyl)pyrolikin-3-amine dihydrochloride (R)-3-methyl-1-((R)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinolin-2-il)- [1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinolin-2-il)- [1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-3-methyl-1-((R)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (R)-1-((S)-1-(3-(8-cyclopropylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)-3-methylpyrrolidin-3-amine dihydrochloride (R)-1-((R)-1-(3-(8-cyclopropylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)-3-methylpyrrolidin-3-amine dihydrochloride (R)-1-((R)-1-(3-(8-cyclopropylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)-3-methylpyrrolidin-3-amine dihydrochloride (S)-1-(S)-1-(3-(8-cyclopropylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)-3-methylpyrolidin-3-amine dihydrochloride (S)-1-((R)-1-(3-(8-cyclopropylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)-3-methylpyrolidin-3-amine dihydrochloride (S)-1-(R)-2,2,2-trifluoro-1-(3-(6-fluoro-8-(2-methoxyethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine hydrochloride 2-(2-(6-((R)-1-((S)-aminopyrrolidin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)quinolin-8-il)-2-methylpropanitrile dihydrochloride 2-((S)-1-((R)-1-(3-(8-tertiary-butylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrolidin-3-ylamino)ethanol dihydrochloride 2-((S)-1-((R)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolikin-3-ylamino)ethanol dihydrochloride 2-((S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-8-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-ilamino)ethanol dihydrochloride (R)-1-((S)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-ilamino)ethanol dihydrochloride (R)-1-((S)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)pyrrolin-3-ol (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-(1-methoxy-2-methylpropan-2-il)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolin-3-amine dihydrochloride N-(2-(6-((R)-2,2,2-trifluoro-1-((S)-3-hydroxypyrrolidin-1-il)ethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-il)quinolin-7-il)isobutyramide N-(2-(6-((R)-2,2,2-trifluoro-1-(S)-3-hydroxypyrrolidin-1-il)ethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-il)quinolin-7-il)pivalamide (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-fluoro-8-(2-methoxyethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine hydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-fluoro-8-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine hydrochloride (S)-1-(R)-1-(3-(8-(1,3-dimethoxy-2-methylpropan-2-il)quinolin-2-il)- [1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-(2-methoxyethyl)quinolin-2-il)- [1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-(1-(methoxymethyl)cyclopropyl)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-7-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine hydrochloride (1-(2-(6-(R)-1-((S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-A]pyridin-3-il)quinolin-8-il)cyclopropyl)methanoldihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-8-methoquinolin-2-il)- [1,2,4]triazolo[4,3-A]pyridin-6-il)ethyl)pyrolidin-3-aminehydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-(2-methoxyethoxy)-8-methylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine hydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-(2-methoxyethoxy)-8-methylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine hydrochloride (3S)-1-((1R)-2,2,2-trifluoro-1-(3-(8-(1-methoxypropan-2-iloxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3-amine hydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-7-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3-amine hydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-7-(2-methoxyethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)ethyl)pyrrolidin-3-amine hydrochloride 2-(2-(6-((R)-1-((S)-aminopyrrolidin-1-yl)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-A]pyridin-3-yl)-6-fluoroquinolin-8-yl)-2-methylpropan-1-oldihydrochloride 2-(2-(6-((R)-1-((S)-3-aminopyrrolidin-1-yl)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-A]pyridin-3-yl)-6-fluoroquinolin-7-yloxy)ethyl acetate hydrochloride 2-(2-(6-((R)-1-((S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-1a]pyridin-3-il)-6-fluoroquinolin-7-iloxy)ethanol hydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-methoxy-8-methylquinolin-2-il)- [1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3-amine hydrochloride (1-(2-(6-(R)-1-((S)-3-aminopyrolidin-1-yl)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-A]pyridin-3-yl)-6-fluoroquinolin-8-yl)cyclopropyl)methanoldihydrochloride (S)-1-(R)-2,2,2-trifluoro-1-(3-(6-fluoro-8-(1-(hydroxymethyl)cyclopropyl (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-methoxy-6-methylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3-amine hydrochloride (3S,4R)-4-amino-1-(R)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3-amine hydrochloride (3S,4R)-4-amino-1-(R)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3-oldihydrochloride (3S,4R)-4-amino-1-(R)-1-1-(8-tertiary-butylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2-trifluoroethyl)pyrrolidin-3-oldihydrochloride (3S,4R)-4-amino-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-7-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-oldihydrochloride (3S,4R)-4-amino-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-8-isoprop oxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-allidrochloride (S)-1-((R)-1-(3-(7-ethoxy-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine hydrochloride (S)-1-((R)-1-(3-(7-(cyclopropylmethoxy)-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine hydrochloride (S)-1-((S)-2,2,2-trifluoro-1-(3-(6-fluoro-8-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine hydrochloride (3S,4R)-4-amino-1-(R)-2,2,2-trifluoro-1-(3-(6-fluoro-7-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine hydrochloride (3S,4R)-4-amino-1-(R)-2,2,2-trifluoro-1-(3-(8-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-ol dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine hydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-((S)-1-methoxypropan-2-yloxy) quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-((S)-1-methoxypropan-2-yloxy) quinolin-2-yl)-[1,2,4]triazolo[4,3-1a]pyridim-6-yl)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-1-(3-(8-cyclopropyl-7-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride (3S)-1-((1R)-2,2,2-trifluoro-1-(3-(8-methyl-8,9-dihydrofuro[2,3-H]quinolin Lin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (3R,4R)-4-amino-1-((R)-1-(3-(8-tertiary-butylquinolin-2-il)- [1,2,4]triazolo[4,3-a]pyridim-6il)-2,2,2-trifluoroethyl)pyrrolidin-3-ol dihydrochloride (3R,4R)-4-amino-1-((R)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinolin Lin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3-oldihydrochloride (3R,4R)-4-amino-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-8-isoprop) (S)-1-(R)-2,2,2-trifluoro-1-(3-(7-(2-methoxyethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-((R)-1-methoxypropan-2-yloxy) quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-(S)-1-methoxypropan-2-yloxy) quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-(R)-1-(3-(8-cyclopropyl-7-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-1-(3-(8-cyclopropyl-7-(2-methoxyethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-6-fluoro-7-(2-mexiethyl)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridine-6-il)ethyl)pyrolikin-3-amine dihydrochloride (S)-3-(fluoromethyl)-1-((R)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridine-6-il)ethyl)pyrolikin-3-amine dihydrochloride (R)-3-(fluoromethyl)-1-((R)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridine-6-yl)ethyl)pyrrolidine-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-6-fluoro-7-(tetrahydro-2H-pyran-4-iloxy)quinolin-2-il)-[1,2,4]trialo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine hydrochloride 2-(6-(R)-1-((S)-3-aminopyrrolidin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)-6-fluoroquinolin-7-ol hydrochloride (S)-1-((R)-1-(3-(8-(cyclopropylmethoxy)-6-fluoroquinolin-2-yl)-[1.2,4]triazolo[4,3-A]pyrilin-6-yl)-2,2,2-trifluoroethyl)pyrolidin-3-amine hydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-6-fluoro-7-((R)-1-methoxypropan-2-yloxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-6-fluoro-7-(R)-1-methoxypropan-2-yloxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((S)-2,2,2-trifluoro-1-(3-(8-(trifluoromethyl)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolicin-3-amine dihydrochloride (3R)-4-fluoro-1-((R)-2,2-trifluoro-1-(3-(6-fluoro-7-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolicin-3-amine dihydrochloride 2-(6-((R)-1-(S)-3-aminopyrolidin-1-yl)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-fluoroquinolin-8-ol hydrochloride (1-(2-(6-(R)-1-((S)-3-aminopyrolidin-1-yl)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-fluoroquinolin-7-yl)cyclopropyl)methanoldihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-7-(1-(methoxymethyl)cyclopropyl (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-fluoro-7-(2-metceethyl)quinolin-2- (S)-[1,2,4]triolin[4,3-A]pyridin-6- (Tethyl)pyridin-3-Amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-fluoro-7-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (R)-3-(fluoromethyl)-1-((R)-2,2,2-trifluoro-1-(3-(8-methoxyquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-amine (R) 3-(fluoromethyl)-1-((R)-2,2,2-trifluoro-1-(3-(8-methoxyquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-amine (S)-1-((R)-2,2,2-trifluoro-1-(8-fluoro-7-(1-methyl-1H-pyrazole-4-il)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine trihydrochloride (S)-1-((R)-1-(3-(7-cyclopropyl-8-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-7-(1-methyl-1H-pyrazole-4-yl)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-amine tri-hydrochloride (S)-1-((R)-1-(3-(8-chloro-7-(2-methoxyethoxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-2,2,2-trifluoroethyl)pyrrolidin-3-amine hydrochloride (S)-1-((R)-1-(3-(8-chloro-7-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrolidin-3-amine hydrochloride (S)-1-((R)-1-(3-(7-cyclopropyl-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrolikin-3-amine hydrochloride (S)-1-((R)-1-(3-(8-cyclopropyl-6-fluoroquinolin-2-il)-[1,2,4]triazolo Solo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-1-(3-(6,8-difluoro-7-methoxyquinolin-2-il)-[1,2,4]triazolo [4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifuguoro-1-(3-(8-fluoro-7-(2-methoxyethoxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-a)pyridin-6-yl)ethyl)pyrolidin-3-amine chihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-fluoro-7-(R)-1-methoxypropan-2-yloxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-aminedihydrochloride (3R,4R)-4-amino-1-(R)-1-(3-(8-cyclopropyl-6-fluoroquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-2,2,2-trifluoroethyl)pyrrolidin-3-oldihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-chloroquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-methylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-8-methylquinolin-2-il)- [1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-(methoxymethyl)quinolin-2-il)- [1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (R)-2-(2-(6-((R)-1-(S)-3-amipyrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-il)quinolin-8-iloxy)propan-1-oldihydrochloride (S)-1-(2-(6-((R)-1-(S)-3-amipyrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-il)quinolin-8-iloxy)propan-2-oldihydrochloride ((R)-3-amino-1-((R)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidim-3-il)methanol dihydrochloride ((R)-3-amino-1-((R)-1-(3-(8-tertiary-butylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidim-3-il)methanol dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-methyl-7-(4-methyl-1H-pyrazol-1-il) quinolin-2-ig)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-methyl-7-(1-methyl-1H-pyrazol-4-il) quinolin-2-ig)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-((3-methyloxytan-3-il)methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine diformate diastereomer 1 of 3-methyl-1-((R)-2,2,2-trifluoro-1-(3-(8-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a)pyridin-6-il)ethyl)pyrrolidin-3-ol hydrochloride Diasteromer 2 of 3-methyl-1-((R)-2,2,2-trifluoro-1-(3-(8-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3-ol hydrochloride Diasteremer 1 of 1-((R)-1-1-(3-(8-tertiary-butylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)-3-methylpyrolidin-3-olhydrochloride. Diasteremer 2 of 1-((R)-1-(3-(8-tertiary-butylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)-3-methylpyrolidin-3-olhydrochloride. (3-amino-1-((R)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-il)methanol dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-((3-methyloxytan-3-il)methoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine diformate 3-methyl-1-((s)-2,2,2-trifluoro-1-(3-(8-isopropoxycetinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-ol hydrochloride diastereomer 1 3-methyl-1-((s)-2,2,2-trifluoro-1-(3-(7-(1-methyl-1h-pyrazol-4-il)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-ol hydrochloride Diasteromer 2 of 3-methyl-1-((s)-2,2,2-trifluoro-1-(3-(7-(1-methyl-1H-pyrazol-4-il)quinolin-2-il)-[1,2,4]triazolo[4,3-a)pyridim-6-il)ethyl)pyrolidin-3-ol hydrochloride Diasteremer 1 of 3-methyl-1-((s)-2,2,2-trifluoro-1-(3-(6-fluoro-8-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-ol hydrochloride. Diasteremer 2 of 3-methyl-1-((s)-2,2,2-trifluoro-1-(3-(6-fluoro-8-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-ol hydrochloride. (3S)-1-((1R)-1-(3-(7-(1,3-dimethyl-1H-pyrazol-5-il)-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)2,2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride (3S)-1-((R)-1-(3-(1,3-dimethyl-1H-pyrazol-4-il)-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine (3S)-1-((1R)-1-(3-(1,5-dimethyl-1H-pyrazol-4-il)-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)2,2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride 3-methyl-1-(S)-2,2,2-trifluoro-1-(3-(8-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)ethyl)pyrrolidin-3-ol hydrochloride Diasteremer 2 2-(6-((R)-1-((S)-3-aminopyrrolidin-1-yl)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-oldihydrochloride 2-(6-(R)-1-((S)-3-aminopyrrolidin-1-yl)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-yl)-M-isopropyl-8-methylquinolin-7-carboxamide (3R,41OS)-4-fluoro-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-7-methoxyquinolin-7-carboxyamide Nolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (3R,4R)-4-fluoro-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-7-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-1amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-(S)-2-methoxypropoxy)quinolin-2- il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (3S)-1-((1R)-1-(3-(7-(1,3-dimethyl-1H-pyrazol-5-il)-8-methylquinolin-2- il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine (3S)-1-((1R)-1-(3-(1,5-dimethyl-1H-pyrazol-4-il)-8-methylquinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3amine dihydrochloride (S)-1-(R)-1-(3-(7-(difluoromethoxy)-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrolidin-3-amine dihydrochloride (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(6-fluoro-8-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3-amine dihydrochloride (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(8-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(6-fluoro-8-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine 2-(2-(6-((R)-1-((S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-A]pyridin-3-il)quinolin-8-iloxy)ethanol dihydrochloride (S)-1-(1os)-1-(3-(7-ethoxy-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)-2,2,2-trifluoroethyl)-3-methylpyrolidin-3-amine (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(6-fluoro-8-((R)-1-methoxypro (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(7-(1-methyl-1H-pyrazol-4-yl) Quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrolidin-3-amine dihydrochloride (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(7-(1-methyl-1H-pyrazol-4-yl) Quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrolidin-3-amine dihydrochloride (S)-1-(S)-1-(3-(7-cyclopropylquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin (2-(6-((R)-1-((S)-3-aminopyrrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-A]pyridin-3-il)quinolin-8-il)-3-methylbutan-1-ol dihydrochloride (2-(6-((R)-1-((S)-3-aminopyrrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo(4,3-A]pyrilim-3-il)quinolin-8-il)propan-2-ol (S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-7-(2,2,2-trifluoroethoxy)quinolin-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-(2-methoxyethoxy)quinolin [1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((R)-1-(3-(8-(difluoromethoxy)-6-fluoroquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-2,2,2-trifluoroethyl)pyrrolidin-3-aminedihydrochloride 3-(2-(6-((R)-1-((S)-3-aminopyrrolidin-1-yl)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-fluoroquinolin-8-yloxy)propan-1-oldihydrochloride 2-(2-(6-((R)-1-((S)-3-aminopyrrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-A]pyridin-3-il)quinolin-8-il)propan-2-oldihydrochloride 2-(2-(6-((R)-1-((S)-3-aminopyrrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-A]pyridin-3-il)quinolin-8-il)propan-2-oldihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-8-(2,2,2-trifluoroethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyrillin-6-il)ethyl)pyrolikin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-8-(3-methoxypropoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyrillin-6-il)ethyl)pyrolikin-3-amine dihydrochloride 2-(2-(6-((R)-1-((S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-A]pyridin-3-il)quinolin-8-il)-N,N-dimethylacetamide dihydrochloride 2-(2-(6-((R)-1-((S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-A]pyridin-3-il)quinolin-8-il)-M-ethylacetamide dihydrochloride 2-(2-(6 <(R)-1-((S)-3aminopyrolidin-1-yl)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yl)propan-2-oldihydrochloride 2-(2-(6-((R)-1-((S)-aminopyrolidin-1-yl)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yl)propan-2-oldihydrochloride (R)-2-(2-(6-((R)-1-((S)-3-aminopyrilidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-il)-6-fluoroquinolin-8-iloxy)propan-1-oldihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-(trifluoromethoxy)quinolin-2-il)- [1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrilidin-3-aminedihydrochloride (R)-3-methyl-1-((R)-2,2,2-trifluoro-1-(3-(8-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (R)-3-methyl-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-8-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride diasteremer 1 of 3-ethyl-1-((R)-2,2,2-trifluoro-1-(3-(8-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride 1-((R)-1-(3-(7-ethoxy-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)-3-ethylpyridin-3-amine dihydrochloride diasteromer 1 of 1-((R)-1-(3-(7-ethoxy-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)-3-ethylpyridin-3-amine dihydrochloride diasteromer 2 of 3-ethyl-1-((S)-2,2,2-trifluoro-1-(3-(8-methoxyqui Nolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride Diasteromer 2 of 1-((S)-1-(3-(7-ethoxy-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)-3-ethylpyrolidin-3-amine dihydrochloride (S)-3-methyl-1-((R)-2,2,2-trifluoro-1-(3-(8-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3-amine dihydrochloride (S)-1-(R)-1-(3-(7-ethoxy-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)-3-methylpyrrolidin-3-amine dihydrochloride (S)-3-methyl-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-8-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-(1OS)-1-(3-(7-ethoxy-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride diasteremer 1 of 3-ethyl-1-((S)-2,2,2-trifluoro-1-(3-(8-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride Diasteremer 1 of 1-((s)-1-(3-(7-ethoxy-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)-3-ethylpyrrolidin-3-amine dihydrochloride. Diasteremer 2 of 3-ethyl-1-((r)-2,2,2-trifluoro-1-(3-(8-methoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride. Diasteremer 2 of 1-((r)-(3-(7-ethoxy -6-fluoroquinoin-2-yl)-[1,2,4]triazolo[4,3-a]pyridim-6-yl)-2,2,2-trifluoroethyl)-3-ethylpyrrolidin-3-aminedihydrochloride 2-(2-(6-((r)-1-((s)-3-aminopyrrolidin-1-yl)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-quinolin-8-yloxy)ethanoldihydrochloride (S)-1-((R)-1-(3-7-ethoxyquinolin-2-il)[1,2,4]triazolo[4,3-a]pyridin--6-il)-2,2,2-trifluoroethyl)pyrolidin-3-amine dihydrochloride 7-ethoxy-2-(6-((1R)-2,2,2-trifluoro-1-(1,7-chiazaspiron[4.4]nonan-7-il)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)quinolin dihydrochloride 7-ethoxy-2-(6-((1s)-2,2,2-trifluoro-1-(1,7-diazaspiron[4.4]nonan-7-il)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)quinoline dihydrochloride 1-(2-(6-(R)-1-((S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-A]pyridin-3-il)-6-fluoroquinolin-8-iloxy)-2-methylpropan-2-ol formate (S)-3-methyl-1-(S)-2,2,2-trifluoro-1-(3-(7-(2-methoxyethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)ethyl)pyrolidin-3-amine dihydrochloride (S)-3-methyl-1-((R)-2,2-trifluoro-1-(3-(7-(2-methoxyethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((S)-1-(3-(7-ethoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)-methylpyrrolidin-3-amine dihydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(8-(1-methoxy-2-methylpropan-2-yloxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-A]pyridin-6-yl)ethyl)pyrrolidin-3-amineformate (S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-8-(1-methoxy-2-methylpropan-2-yloxy)quinolin-2-yl)-1,2,4]triazolo[4,3-a]pyrikim-6-yl)ethyl)pyrrolidin-3-amineformate 2-(2-(6-((R)-1-((S)-3-aminopyrrolidin-1-yl)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-7-yl)ethanoldihydrochloride (S)-1-((R)-1-(3-(7-(ethylthio)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-aminedrochloride 2-(2-(6-((R)-1-((S)-3-aminopyrrolidin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)quinolin-7-ylthio)ethanol hydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-(isopropylthio)quinolin-2-il)- [1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine hydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-(2-methoxyethyl)quinolin-2-il)- [1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride 2-(2-(6-((R)-1-((S)-3-aminopyrrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-A]pyridin-3-il)quinolin-8-iloxy)acetonitrileformate ((S)-1-(R)-1-(3-(8-(1,3-dimethoxypropan-2-iloxy)quinolin-2-il)- [1,2,4]triazolo[4,3-A]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride 1-(2-(6-((R)-1-((R)-3-amino-3-methylpyrrolidin-1-il)-2,2,2-trifluoroethyl Ethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)quinolin-8-iloxy)-2-methylpropan-2-oldihydrochloride (S)-1-(R)-1-(3-(8-(ethylthio)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-aminedihydrochloride (S)-1-((R)-1-(3-(7-ethoxyethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-aminedihydrochloride (A)-1-((R)-2,2,2-trifluoro-1-(3-(7-(3-methoxypropoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine dihydrochloride (1A)-1-((R)-2,2,2-trifluoro-1-(3-(8-(2-methoxy-2-methylpropoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine formate (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-((R)-2-methoxypropoxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-A]pyridin-6-yl)ethyl)pyrrolidin-3-amine dihydrochloride 1-(2-(6-((R)-1-((S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-1a]pyridin-3-il)quinolin-7-iloxy)-2-methylpropan-2-oldihydrochloride ((S)-1-(R)-1-(3-(7-ethoxy-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrolidin-3-il)methanamine hydrochloride ((R)-1-(R)-1-(3-(7-ethoxy-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-il)methanamine hydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-(2-(methylthio)ethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine hydrochloride (R)-1-(R)-1-(3-(7-ethoxy-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridim-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine hydrochloride (R)-1-(2-(6-((R)-1-((S)-3-aminopyrrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-il)quinolin-8-iloxy)propan-2-olformate (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(6-fluoro-7-(2-methoxyethyl)quinolin-8-iloxy)propan-2-olformate Nolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3-amine dihydrochloride 2-(2-(6-((R)-1-(S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-a]pyridin-3-il)-6-fluoroquinolin-7-iloxy)ethyl isobutyrate 2-(2-(6-((R)-1-((S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-A]pyridin-3-il)-6-fluoroquinolin-7-iloxy)ethylpyvalate (S)-1-(R)-2,2,2-trifluoro-1-(3-(7-((S)-2-methoxypropoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)ethyl)pyrolidin-3-aminedihydrochloride 2-(2-(6-((R)-1-((S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-A]pyridin-3-il)-6-fluoroquinolin-7-iloxy)ethyl 2-ethylbutanoate 2-(2-(6-((R)-1-((S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazolo[4,3-A]pyridin-3-il)-6-fluoroquinolin-7-iloxy)ethyl 2,2-Chymethylbutanoate (S)-2-(2-(6-((R)-1-(S)-3-aminopyrolidin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-A]pyridin-3-il)-6-fluoroquinolin-7-iloxy)ethyl 2-amino-3-methylbutanoate (S)-1-(R)-2,2,2-trifluoro-1-(3-(8-(R)-2-methoxypropoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)ethyl)pyrolikin-3-amineformate (R)-1-(1OS)-1-(3-(7-ethoxy-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)-2,2,2-trifluoroethyl)pyrrolidin-3-amine hydrochloride (R)-1-((R)-1-(3-(7-ethoxy-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)-2,2,2-trifluoroethyl)-3-methylpyrrolidin-3-amine hydrochloride (R)-1-((S)-1-(3-(7-ethoxy-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)-2,2,2-trifluoroethyl)-3-methispyridin-3-amine hydrochloride ((S)-1-(S)-1-(3-(7-ethoxy-6-fluoroquinolin-2-il)-[1,2,4]triazolo [4,3-A]pyridin-6-il)-2,2-trifluoroethyl)pyridin-3-il)methanamine hydrochloride ((R)-1-((S)-1-(3-(7-ethoxy-6-fluoroquinolin-2-il)-[1,2,4]triazolo [4,3-a]pyridin-6-yl)-2,2,2-trifluoroethyl)pyrrolidin-3-yl)methanamine hydrochloride 1-(2-(6-((s)-1-((s)-3-amino-3-methylpyrrolidin-1-yl)-2,2,2-trifluoroethyl Ethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-7-yloxy)-2-methylpropan-2-oldihydrochloride (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(6-fluoro-7-(2-methoxyethoxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrolidin-3-aminedihydrochloride (3R,4R)-1-((R)-1-(3-(7-ethoxy-6-fluoroquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrr ... Solo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)-4-methoxypyrolidin-3-amine dihydrochloride (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(7-(2-methoxyethyl)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3-amine dihydrochloride 1-(2-(6-((S)-1-((S)-3-amino-3-methylpyrolidin-1-il)-2,2,2-trifluoro Ethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-fluoroquinolin-7-yloxy)-2-methylpropan-2-ol dihydrochloride 1-(2-(6-((R)-1-((S)-3-aminopyrrolidin-1-yl)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-fluoroquinolin-7-yloxy)-2-methylpropan-2-ol dihydrochloride (S)-N,N-dimethyl-1-((R)-2,2,2-trifluoro-1-(3-(8-((R)-1-terxipro (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(7-((S)-2-methoxypropoxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrolidin-3-amine dihydrochloride (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(7-((S)-2-methoxypropoxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrolidin-3-amine (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(7-((R)-2-methoxypropoxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrolidin-3-amine (S)-1-((S)-1-(3-(7-ethoxyethoxy)quinolin-2-il)-[1,2,4]triazolo [4,3-a]pyridin-6-il)ethyl)pyrolidin-3-amine (S)-1-((R)-1-(3-(8-tertiary-butylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)-2,2,2-trifluoroethyl)-3-methylpyrolidim-3-amine (S)-1-((R)-1-(3-(8-tertiary-butylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3-amine trihydrochloride (S)-1-((S)-1-(3-(8-tertiary-butylquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine trihydrochloride (S)-1-((R)-1-(3-(7-ethoxy-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine trihydrochloride (S)-1-((S)-1-(3-(7-ethoxy-6-fluoroquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine trihydrochloride (S)-3-methyl-1-((S)-2,2-trifluoro-1-(3-(6-fluoro-7-(2-methoxyethyl)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridim-6-il)ethyl)pyrrolidin-3-amine (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(7-methoxyquinolin-2-il)- [1,2,4]triazilo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine 2-((2-(6-((R)-1-((S)-3-aminopyrrolidin-1-il)-2,2,2-trifluoroethyl)- [1,2,4]triazilo[4,3-a]pyridin-3-il)-6-fluoroquinolin-7-il)oxy)ethylbenzoate (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(7-isopropoxyquinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(7-((R)-1-methoxypropan-2-il)oxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-(oxytan-3-il)quinolin-2-il)- [1,2,4]triazilo[4,3-a]pydim-6-il)ethyl)pyrrodin-3-amine 2-(2-(6-((S)-1-((S)-3-amino-3-methylpyrrodin-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazilo[4,3-a]pydim-3-il)quinolin-7-il)ethanol (3R,4R)-4-methoxy-1-(R)-2,2,2-trifluoro-1-(3-(7-(2-methoxyethoxy)quinolin-7-il) Quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3-amine diasteromer 1 of trams-2-((2-(6-(r)-((s)-3-laminopyrilidim-1-il)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-il)quinolin-7-il)oxy)cycloclopentanol dihydrochloride (5-methyl-2-oxo-1,3-dioxol-4-il)methyl ((S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-7-(2-hydroxyethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-A]pyrilin-6-il) ethyl)pyrolidin-3-il)carbamate (S)-3-methyl-1-(S)-2,2,2-trifluoro-1-(3-(6-fluoro-7-((S)-2-methoxypropyl (S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-7-((S)-2-methoxypropoxy) Quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3-aminedi-hydrochloride (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(6-fluoro-7-((S)-2-methoxypropoxy) Quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrolidin-3-aminedi-hydrochloride (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(6-fluoro-7-((R)-2-methoxypropoxy C)Quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidim-3-aminedi-hydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-7-((R)-2-methoxypropoxy)Quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidim-3-aminedi-hydrochloride (S)-1-((R)-2,2,2-trifluoro-1-(3-(3-fluoro-7-(2-methoxyethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine (S)-3-methyl-1-((R)-2,2,2-trifluoro-1-(3-(3-fluoro-7-(2-methoxyethoxy)quinolin-2-il)-[1,2,4]triazolo[4,3-a]pyridin-6-il)ethyl)pyrrolidin-3-amine (S)-1-((R)-2,2,2-trifluoro-1-(3-(3-fluoro-7-((R)-2-methoxypropoxy) quinolin-2-il)-[1,2,4]triazolo[4,3-A]pyridin-6-il)ethyl)pyrolidin-3-amine

34. A composition consisting of one of the compounds described in any of the claims under clauses 1-33, or a pharmaceutically acceptable salt of such compound, and a pharmaceutically acceptable diluent or carrier.

35. A compound with structural formula I as defined in any of the claims 1 through 33, or a pharmaceutically acceptable salt of such compound for use in the treatment of diseases caused by inflammation or autoimmune disease.

36. A compound as defined in claim 35, whereby the disease caused by inflammation or autoimmune disease is: multiple sclerosis, lupus, inflammatory bowel disease, or rheumatoid arthritis.

37. A compound with structural formula I as defined in any of the claims 1 through 33, or a pharmaceutically acceptable salt of such compound, for use in the treatment of cancer.

38. A compound with structural formula I as defined in one of the claims from 1 to 33, or a pharmacologically acceptable salt of such compound, for use in the manufacture of a drug to treat a condition in which PIM-1 and/or PIM-2 and/or PIM-3 kinases are mediated in mammals.

39. A compound with structural formula I as defined in one of the claims 1 through 33, or a pharmacologically acceptable salt of such compound, for use in the manufacture of drugs to treat an inflammatory or autoimmune disorder in mammals.

40. Compounds as defined in claim 39, whereby the inflammatory or autoimmune diseases mentioned are multiple sclerosis, lupus, inflammatory bowel disease, or rheumatoid arthritis.

41. Any compound as defined in any of the claims 1 through 33, or a pharmaceutically acceptable salt of such compound, for use in the manufacture of drugs to treat cancer in patients.

42. A process for the preparation of a compound of claim I which consists of (a) the reaction of a coherent compound of structural formula II or a protected derivative of such compound (chemical formula) in which R4 satisfies as specified for structural formula I with a coherent compound of structural formula III or a protected derivative of such compound (chemical formula) in which R1, R2 and R3 satisfies as specified for structural formula I in the presence of an organo-hypervalent iodine reagent; or (b) for a compound of structural formula I in which R2 is hetAr1 or a cyclopropyl ring of alternative substitution of -CH2OH or -CH2O(1-6C alkyl), the reaction of a coherent compound of structural formula IV or a protected derivative of such compound (chemical formula) in which R1, R2 and R3 satisfies as specified for structural formula I (c) For one such compound (chemical formula) in which R1, R3 and R4 satisfy the definition for structural formula I, with one such reactant (chemical formula) in which hetAr1 satisfy the definition for structural formula I, Cyc is cyclopropyl with alternative substitution of -CH2OH or -CH2O(1-6C alkyl) and Rx and Ry are H or (1-6C)alkyl, or Rx and Ry, when attached to the atoms to which such groups are attached, form a 5-6 polygonal ring with alternative substitution of 1-4 substituents chosen from (1-3C alkyl), where the reaction occurs in the presence of a palladium catalyst and by alternatively in the presence of a ligand and a ligand, or (c) for one such compound with structural formula I in which R2 is -NReC(=O)Rf, the reaction of one such corresponding compound with structural formula IV or its protected derivative. (d) for a compound with structural formula I, where R2 is (1-6C alkyl)sulfanyl or hydroxy(2-6C alkyl)sulfanyl; coupling of a corresponding compound with structural formula IV or a protected derivative of such compound (chemical formula), where R1, R2, R3, and R4 satisfy the requirements for structural formula I, with a reagent of structural formula HNReC(=O)Rf, while a base and a metal catalyst are present; or (e) for a compound with structural formula I, where R2 is -C(=O)NReRf; coupling of a corresponding compound with structural formula V or a protected derivative of such compound (chemical formula), where R1, R2, R3, and R4 satisfy the requirements for structural formula I, with a reagent of structural formula HS(1-6C alkyl) or HS(1-6C alkyl)OH, respectively, while a different type is present; or (e) for a compound with structural formula I, where R2 is -C(=O)NReRf; coupling of a corresponding compound with structural formula V or a protected derivative of such compound (chemical formula). (f) for a compound with structural formula I, where R1 is -CH2C(=O)NRcRd, a coupling of a corresponding compound with structural formula VI, or a protected derivative of such compound (chemical formula), where R2, R3, and R4 are as specified for structural formula I, with a reagent with structural formula HNReRf, where Rc and Rd are as specified for structural formula I, while a base and a coupling reagent are present; or (c) for a compound with structural formula I, where R1 is -CH2C(=O)NRcRd, a coupling of a corresponding compound with structural formula VI, or a protected derivative of such compound (chemical formula), where R2, R3, and R4 are as specified for structural formula I, with a reagent with structural formula HNRcRd, where Rc and Rd are as specified for structural formula I, while a base is present. (c) for a compound of structural formula I, where R2 is (1-6C)alkoxy substituted by (1-6C alkyl)C(=O)O-, a coupling of a corresponding compound of structural formula VII, or a protected derivative of such compound (chemical formula), where R1, R3, and R4 satisfy the requirements for structural formula I with a (1-6C)alkyl anhydride or a (1-6C)alkyl chloride, while a base is present; or (h) for a compound of structural formula I, where R2 is (1-6C)alkoxy substituted by amino(1-6C) Alkyl)C(=O)O- is a coupling of a corresponding compound with structural formula VII or a derivative that provides a type of protective amine of such compound (chemical formula) in which R1, R3, and R4 are as defined for structural formula I with a compound with structural formula P1NH(1-6C alkyl)C(=O)OH, where P1 is H or a protective amine group, while it is alkaline. (1) For a compound with structural formula I, where R4 is part of the structure (chemical formula) in which R5, R5a and R7 satisfy the requirements for structural formula I, R8 is H, halogen, OH or (1-6C) alkoxy, and R9 is H. Reacting with a corresponding compound with structural formula VIII (chemical formula) in which R1, R2, R3, R5, R5a and R7 satisfy the requirements for structural formula I, R8 is H, halogen, OH or (1-6C) alkoxy, and R9 is H with an acid (1-6C) alkylcarboxylic acid anhydride or an acid (1-6C) alkylcarboxylic acid chloride. While there is a type of alkali (ญ) for a compound with structural formula I, where R4 is part of the structure (chemical formula), where R5, R5a, and R7 satisfy the requirements for structural formula I, R8 is H, halogen, OH, or (1-6C) alkoxy, and R9 is H, reacting with a corresponding compound with structural formula VIII (chemical formula), where R1, R2, R3, R5, R5a, and R7 satisfy the requirements for structural formula I, R8 is H, halogen, OH, or (1-6C) alkoxy, and R9 is H with (1-6C) an alkylide or a protected (1-6C) aldehyde, while a type of catalyst and a type of alkali are present, followed by the addition of a receptor. (ฏ) For a compound with structural formula I, where R4 is part of the structure (chemical formula), where R5, R5a, and R7 satisfy the requirements for structural formula I, R8 is H, halogen, OH, or (1-6C) alkoxy, and R9 is H. A reaction with a corresponding compound with structural formula VIII (chemical formula), where R1, R2, R3, R5, R5a, and R7 satisfy the requirements for structural formula I, R8 is H, halogen, OH, or (1-6C) alkoxy, and R9 is H, while there is a reactant with structural formula HC(=O)(1-5C alkyl) and an electron acceptor, or (ฏ) For a compound with structural formula I, where R4 is part of the structure (chemical formula), where R7 satisfy the requirements for structural formula I, R8 is H, halogen, OH, or (1-6C) alkoxy, R9 is H, and P2 is H. Or a protective amine group. The reaction produces a corresponding compound with structural formula IX (chemical formula) where R1, R2, and R3 satisfy those for structural formula I, in the presence of a Lewis acid, followed by the addition of an electron acceptor, the removal of any or various protective groups, and the formation of a salt, if desired.

43. A compound with structural formula II-A (chemical formula) which incorporates the enantiomer and diastereomer of such compound, where P3 is H or a protective amine group and R7 is H, (1-6C)alkyl, fluoro(1-6C)alkyl or hydroxy(1-6C)alkyl.

44. A compound of claim number 43, where R7 is (1-5C)alkyl.

45. A compound of claim 44, where R7 is H or methyl.