TH140652A - Antigens-IGF antibodies - Google Patents
Antigens-IGF antibodiesInfo
- Publication number
- TH140652A TH140652A TH901005583A TH0901005583A TH140652A TH 140652 A TH140652 A TH 140652A TH 901005583 A TH901005583 A TH 901005583A TH 0901005583 A TH0901005583 A TH 0901005583A TH 140652 A TH140652 A TH 140652A
- Authority
- TH
- Thailand
- Prior art keywords
- igf
- insulin
- antibody
- binding
- receptor
- Prior art date
Links
- 102000004965 antibodies Human genes 0.000 title claims abstract 9
- 108090001123 antibodies Proteins 0.000 title claims abstract 9
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims abstract 8
- 102000004877 Insulin Human genes 0.000 claims abstract 4
- 108090001061 Insulin Proteins 0.000 claims abstract 4
- 102400000022 Insulin-Like Growth Factor II Human genes 0.000 claims abstract 4
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims abstract 4
- 102000004218 Insulin-like growth factor I Human genes 0.000 claims abstract 4
- 108090000723 Insulin-like growth factor I Proteins 0.000 claims abstract 4
- 230000001404 mediated Effects 0.000 claims abstract 4
- 102000038595 IGF Type 1 Receptor Human genes 0.000 claims abstract 2
- 108010031794 IGF Type 1 Receptor Proteins 0.000 claims abstract 2
- 102000003746 Insulin Receptor Human genes 0.000 claims abstract 2
- 108010001127 Insulin Receptor Proteins 0.000 claims abstract 2
- 201000011510 cancer Diseases 0.000 claims abstract 2
- 230000002297 mitogenic Effects 0.000 claims abstract 2
- 102000005962 receptors Human genes 0.000 claims abstract 2
- 108020003175 receptors Proteins 0.000 claims abstract 2
- 230000011664 signaling Effects 0.000 claims abstract 2
Abstract
DC60 (25/02/53) โมเลกุลแอนติบอดีโดยเฉพาะแอนติบิดีมนุษย์ที่สมบูรณ์ ที่เกาะจับกับ IGF-1 ของมนุษย์ และทำปฏิกิริยาข้ามกับ IGF-2 ในลักษณะที่ขัดขวางการเกาะจับของ IGF-1 และ IGF-2 กับ IGF-1 รีเซบเตอร์ และยับยั้งการส่งสัญญาณที่สื่อด้วย IGF-1 รีเซบเตอร์ แอนติบอดีนี้ไม่เกาะจับกับอินซูลิน และดังนั้นไม่กระทบสมบัติไมโตเจนิกของอินซูลินที่สื่อ โดยการเกาะจับของมันกับอินซูลินรีเซบเตอร์ แอนติบอดีนี้มีประโยชน์สำหรับการบำบัดโรคไฮเปอร์โพรลิเฟอเรทีฟ โดยเฉพาะมะเร็ง DC60 (25/02/53) Antibody molecules, especially complete human antibodies. Binds to human IGF-1 and interacts with IGF-2 in a way that disrupts the binding of IGF-1 and IGF-2 to IGF-1 receptors and inhibits IGF--mediated signaling. 1 This antibody receptor does not bind to insulin. And therefore does not affect the mitogenic properties of the insulin-mediated By binding of it to the insulin receptor This antibody is useful for the treatment of hyperproperties. Especially cancer
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH140652A true TH140652A (en) | 2015-05-29 |
| TH0901005583A TH0901005583A (en) | 2015-05-29 |
Family
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