TH13940A - Brady Kainin - Antagonis For use in the treatment of acute pancreatitis. - Google Patents

Abstract

This invention involves the use of Bradyquinin-antagonis of the formula R1 - A - B - C - E - F - G - J - K - R2. Here R1 represents the hydrogen C1-4 -alkanoy 1 represented. mercapto, hydroxyphenyl, (4-benzoyl) phenoxy or substitute (4-benzoyl) benzoyl-Lys, A substitute for D-Arg or D-Lys or replace direct bond, B substitute Arg that can be replaced with No2 or tolnol-4 sulfouyl or Instead of Lys, which was represented by tolnol-4-sulfunyl or CO-NH-C6H5 or replace direct bond, C instead of Hyp-Pro-Gly, Pro-Hyp-Gly, Pro-Pro Gly, or dehydro Pro-Hyp-Gly; E instead of Thi, Phe, Len, or Cha; F stands for Ser or Cys; G is for D-tic, D-Phe or D-Hyp is replaced. C1-C4-alkoxy; J stands for Tic, Aoc or Oic, K instead of Arg or Ahx or directly, R2 is hydroxy or amino, and its salt form is physically resistant, for Treatment of acute pancreatitis for medicated agents And the use of including Prepare the appropriate drug ingredient, patent drug

Claims (1)

1. Components of drugs used for the treatment of pancreatitis. Contains the number of active ingredients of Peptide Formula 1 R1 - A - B - C - E - F - G - J - K - R2 (1) Here R1 represents hydrogen, C1 - C4 -alkanoy 1 is represented. With mercapto, hydroxyphenyl, (4-benzoyl) phenoxy, or instead of (4-benzoyl) benzoyl-Lys, A replaces D-Arg or D-Lys, or replaces straight bonds, B replaces Arg that can be replaced with No2 or tolnol-4 sulfouyl. Or instead of Lys, which is represented by tolnol-4-sulfunyl or CO-NH-C6H5 or replace direct bond, C instead of Hyp-Pro-Gly, Pro-Hyp-Gly, Pro-P. Tag: drug patent.