TH137477B - Cancer treatment in mammals By using a combined agent of MEK and / or B-Raf inhibitors. - Google Patents
Cancer treatment in mammals By using a combined agent of MEK and / or B-Raf inhibitors.Info
- Publication number
- TH137477B TH137477B TH1201001681A TH1201001681A TH137477B TH 137477 B TH137477 B TH 137477B TH 1201001681 A TH1201001681 A TH 1201001681A TH 1201001681 A TH1201001681 A TH 1201001681A TH 137477 B TH137477 B TH 137477B
- Authority
- TH
- Thailand
- Prior art keywords
- mek
- mammals
- raf inhibitors
- cancer treatment
- combined agent
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title abstract 4
- 101700004551 BRAF Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 239000011780 sodium chloride Substances 0.000 claims abstract 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate Chemical class CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- -1 3-cyclopropyl Chemical group 0.000 abstract 3
- 229940093912 Gynecological Sulfonamides Drugs 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079867 intestinal antiinfectives Sulfonamides Drugs 0.000 abstract 1
- 229940005938 ophthalmologic antiinfectives Sulfonamides Drugs 0.000 abstract 1
- 239000005426 pharmaceutical component Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 229940026752 topical Sulfonamides Drugs 0.000 abstract 1
Abstract
การรวมกันแบบใหม่ซึ่งประกอบรวมด้วยตัวยับยั้งMEKN-{3-[3-ไซโคลโพรพิล-5-(2- ฟลูออโร-4-ไอโอโด-ฟีนิลอะมิโน)6,8-ไดเมธิล;-2,4,7-ไทรออกโซ-3,4,6,7-เททราไฮโดร-2H-ไพริโด [4,3-d]ไพริมิดิน-1-อิล]ฟีนิล}อะเซทาไมด์ หรือเกลือที่ยอมรับได้ทางเภสัชกรรม หรือโซลเวตของมัน กับตัวยับยั้งB-RafโดยเฉพาะN-{3-[5-(2-อะมิโน-4-ไพริมิดินิล)-2-(1,1-ไดเมธิลเอธิล)-1,3- ไธอะซอล-4-อิล]-2-ฟลูออโรฟีนิล)-2,6-ไดฟลูออโรเบนซีนซัลโฟนาไมด์ หรือเกลือที่ยอมรับได้ทาง เภสัชกรรมของมัน, องค์ประกอบทางเภสัชกรรมซึ่งประกอบรวมด้วยสิ่งเดียวกัน และวิธีของการใช้ การรวมกันเหล่านี้และองค์ประกอบในการรักษาภาวะซึ่งการยับยั้งของ MEK และ/หรือB-Raf เป็น ประโยชน์ เช่น มะเร็ง New combination consisting of a MEKN- (3- (3-cyclopropyl -5- (2-fluoro-4-iodo-phenylamino) inhibitor) - dimethyl; -2,4,7-triaco -3,4,6,7-tetrahydro-2H-pyrido [4,3-d] pyrimidin-1-il] phenyl} acetamide Or a pharmaceutical acceptable salt Or its solvette With B-Raf inhibitors, especially N- (3- (5- (2-amino-4-pyrimidinyl) -2- (1,1-dimethylethyl) -1, 3-thiazol-4-il) -2-fluorophenyl) -2,6-diffluorobenzene sulfonamides Or salt that is acceptable via Its pharmaceuticals, pharmaceutical components which are made up of the same And methods of use These combinations and constituents in the treatment of conditions in which the inhibition of MEK and / or B-Raf is beneficial, such as cancer.
Claims (3)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH137477B true TH137477B (en) | 2014-10-17 |
| TH137477A TH137477A (en) | 2014-10-17 |
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