TH137350B - Aerylmethylbenzoquinazolinone Positive allosteric modulators of M1 receptor - Google Patents
Aerylmethylbenzoquinazolinone Positive allosteric modulators of M1 receptorInfo
- Publication number
- TH137350B TH137350B TH1001000743A TH1001000743A TH137350B TH 137350 B TH137350 B TH 137350B TH 1001000743 A TH1001000743 A TH 1001000743A TH 1001000743 A TH1001000743 A TH 1001000743A TH 137350 B TH137350 B TH 137350B
- Authority
- TH
- Thailand
- Prior art keywords
- receptor
- formula
- aerylmethylbenzoquinazolinone
- positive allosteric
- allosteric modulators
- Prior art date
Links
- 102000017927 CHRM1 Human genes 0.000 title abstract 3
- 108060003365 CHRM1 Proteins 0.000 title abstract 3
- 230000003281 allosteric Effects 0.000 title abstract 2
- 230000000051 modifying Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 4
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 206010001897 Alzheimer's disease Diseases 0.000 abstract 1
- 206010040984 Sleep disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000001404 mediated Effects 0.000 abstract 1
- 201000008175 pain disease Diseases 0.000 abstract 1
- 239000005426 pharmaceutical component Substances 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 230000001225 therapeutic Effects 0.000 abstract 1
Abstract
การประดิษฐ์ครั้งนี้จะเกี่ยวข้องกับสารประกอบเบนโซควินาซิลิโนนตามสูตร(I)(สูตร)ซึ่งคือสารปรับควบคุมอัลโลสเตอริกแบบวกของM1รีเซพเตอร์และที่มีประโยน์ในการบำบัดโรคที่ซึ่งM1รีเซพเตอร์มีส่วนเกี่ยวข้อง,เช่นโรคอัลไซเมอร์,โรคจิตเภท,อาการปวดหรือความผิดปกติเกี่ยวกับการนอนอีกทั้งการประดิษฐ์จะเกี่ยวข้องกับองค์ประกอบเชิงเภสัชกรรมซึ่งประกอบรวมด้วยสารประกอบ,และกเกี่ยวข้องกับการใช้งานของสารประกอบและองค์ประกอบในการบำบัดโรคที่สื่อโดยM1รีเซพเตอร์ This invention involves the benzoquina Silinone compound according to formula (I) (formula), which is the M1 receptor-type allosteric modulator and its useful properties. In the treatment of diseases in which M1 receptors are involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders, and their invention relates to the pharmaceutical components that comprise With compounds, and A are involved in the use of compounds and therapeutic elements mediated by M1 receptor.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH137350A TH137350A (en) | 2014-10-17 |
| TH137350B true TH137350B (en) | 2014-10-17 |
Family
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