TH136428B - Combination therapy of afucosylated CD20 antibody CD20 (afucosylated CD20 antibody) with bentamustine. (bendamustine) - Google Patents
Combination therapy of afucosylated CD20 antibody CD20 (afucosylated CD20 antibody) with bentamustine. (bendamustine)Info
- Publication number
- TH136428B TH136428B TH1201000561A TH1201000561A TH136428B TH 136428 B TH136428 B TH 136428B TH 1201000561 A TH1201000561 A TH 1201000561A TH 1201000561 A TH1201000561 A TH 1201000561A TH 136428 B TH136428 B TH 136428B
- Authority
- TH
- Thailand
- Prior art keywords
- antibody
- afucosylated
- bendamustine
- bentamustine
- combination therapy
- Prior art date
Links
- 102000004965 antibodies Human genes 0.000 title claims abstract 5
- 108090001123 antibodies Proteins 0.000 title claims abstract 5
- YTKUWDBFDASYHO-UHFFFAOYSA-N Bendamustine Chemical compound ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 YTKUWDBFDASYHO-UHFFFAOYSA-N 0.000 title claims abstract 3
- 229960002707 bendamustine Drugs 0.000 title claims abstract 3
- 238000002648 combination therapy Methods 0.000 title abstract 3
- 102100000165 MS4A1 Human genes 0.000 title 2
- 101710010909 MS4A1 Proteins 0.000 title 2
- 201000011510 cancer Diseases 0.000 claims abstract 3
- SHZGCJCMOBCMKK-DHVFOXMCSA-N Fucose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims 1
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000004676 glycans Polymers 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 150000004804 polysaccharides Polymers 0.000 claims 1
Abstract
การประดิษฐ์ปัจจุบันถูกมุ่งตรงไปยังการบำบัดแบบการรวมของ แอนทิบอดีแอนทิ-CD20 อะฟู โคซิเลต (afucosylated anti-CD20 antibody) กับเบนดามัสทีน (bendamustine) สำหรับการรักษาของ มะเร็ง, โดยเฉพาะอย่างยิ่ง ไปยังการบำบัดแบบการรวมของมะเร็งที่แสดงออก CD20 กับ แอนทิบอดี B- Ly1 ซึ่งถูกทำให้มีลักษณะมนุษย์อะฟูโคซิเลตและ เบนดามัสทีน The present invention is directed towards the combination therapy of Antibody-CD20 afucosylated (afucosylated anti-CD20 antibody) with bendamastine. (bendamustine) for the treatment of cancer, especially To the combined therapy of CD20-expressed cancer with the B-Ly1 antibody, which is characterized by human aphucosylate and bentamustine.
Claims (4)
Publications (2)
Publication Number | Publication Date |
---|---|
TH136428A TH136428A (en) | 2014-09-09 |
TH136428B true TH136428B (en) | 2014-09-09 |
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