TH136339B - Combination of ferrocin and artemisinin derivatives. For the treatment of malaria - Google Patents
Combination of ferrocin and artemisinin derivatives. For the treatment of malariaInfo
- Publication number
- TH136339B TH136339B TH601001766A TH0601001766A TH136339B TH 136339 B TH136339 B TH 136339B TH 601001766 A TH601001766 A TH 601001766A TH 0601001766 A TH0601001766 A TH 0601001766A TH 136339 B TH136339 B TH 136339B
- Authority
- TH
- Thailand
- Prior art keywords
- ferrocin
- malaria
- treatment
- combination
- involves
- Prior art date
Links
- BLUAFEHZUWYNDE-NNWCWBAJSA-N Artemisinin Chemical class C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 title claims abstract 5
- HJCYGTUHOXJXHD-IERUDJENSA-N Ferrocin Chemical compound O=C1NCC(=O)NC(C(C)C)C(=O)NC(CO)C(=O)NC2C(=O)NC(C)C(=O)NCC(=O)NC(CCCN([C-]([OH+]3)C)O4)C(=O)NCC(=O)OCC(NC(=O)C\C=C\CCCCCC)C(=O)NC1CCCN(O1)[C-](C)[OH+][Fe]134(O1)[OH+][C-](C)N1CCC2 HJCYGTUHOXJXHD-IERUDJENSA-N 0.000 title abstract 3
- 201000004792 malaria Diseases 0.000 title abstract 3
- 150000004677 hydrates Chemical class 0.000 claims abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- SXYIRMFQILZOAM-HVNFFKDJSA-N (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepines Chemical compound C1C[C@H]2[C@H](C)CC[C@H]3[C@@H](C)[C@@H](OC)O[C@H]4[C@]32OO[C@@]1(C)O4 SXYIRMFQILZOAM-HVNFFKDJSA-N 0.000 claims 1
- DLYPREQTTOHKSM-UHFFFAOYSA-N 7-chloro-N-[[2-[(dimethylamino)methyl]cyclopenta-1,4-dien-1-yl]methyl]quinolin-4-amine;cyclopenta-1,3-diene;iron(2+) Chemical compound [Fe+2].C1C=CC=[C-]1.C1=[C-]CC(CN(C)C)=C1CNC1=CC=NC2=CC(Cl)=CC=C12 DLYPREQTTOHKSM-UHFFFAOYSA-N 0.000 claims 1
- 229950010451 Ferroquine Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229960000981 artemether Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000000890 drug combination Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000011780 sodium chloride Substances 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drugs Drugs 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 230000001225 therapeutic Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับการใช้ยาร่วมกันซึ่งประกอบรวมด้วยเฟอร์โรควินในรูปฟรีเบส, เกลือ, ไฮเดรต หรือโซเวต และอนุพันธ์อาร์ทีมิซินิน. การประดิษฐ์ยังเกี่ยวข้องกับสารผสมทางเภสัชกรรม ซึ่งประกอบรวมด้วย เฟอร์โรควิน, ในรูป ของชนิดใดชนิดหนึ่งของเกลือ ของไฮเดรต หรือของโซลเวตที่ยอมรับได้ทางเภสัชกรรมของเฟอร์โรควิน, และอนุพันธ์อาร์ทีมิซินินอย่างน้อยที่สุดหนึ่งชนิด การประดิษฐ์นี้ยังเกี่ยวข้องกับการใชัยาร่วมกันดังกล่าวสำหรับการเตรียมผลิตภัณฑ์ยาสำหรับใช้ ในการรักษา หรือ การป้องกันมาลาเรีย สุดท้าย การประดิษฐ์นี้เกี่ยวข้องกับชุดอุปกรณ์สำหรับการรักษาหรือ การป้องกันมาลาเรีย The invention involved a combination of drugs that included ferrocin as free bases, salts, hydrates or sovates, and artemisinin derivatives. The invention also involves pharmaceutical mixtures. It contains ferrocin, in the form of either a type of hydrate salt or of a chemically acceptable ferrocinate salt, and at least one artemisinin derivative. type The invention also involves the use of such drugs for the preparation of medicinal products for use in the treatment or prevention of malaria. Finally, this invention involves a therapeutic kit or Malaria prevention
Claims (2)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH136339A TH136339A (en) | 2014-09-01 |
| TH136339B true TH136339B (en) | 2014-09-01 |
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