TH135295B - Pyrazolospirokeatone derivative for use as an acetyl-COA carboxylase inhibitor. - Google Patents
Pyrazolospirokeatone derivative for use as an acetyl-COA carboxylase inhibitor.Info
- Publication number
- TH135295B TH135295B TH1301005986A TH1301005986A TH135295B TH 135295 B TH135295 B TH 135295B TH 1301005986 A TH1301005986 A TH 1301005986A TH 1301005986 A TH1301005986 A TH 1301005986A TH 135295 B TH135295 B TH 135295B
- Authority
- TH
- Thailand
- Prior art keywords
- acetyl
- pyrazolospirokeatone
- derivative
- coa carboxylase
- carboxylase inhibitor
- Prior art date
Links
- 229940121373 acetyl-CoA carboxylase inhibitors Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 239000011780 sodium chloride Substances 0.000 claims abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- KLTWGRFNJPLFDA-UHFFFAOYSA-N benzimidazolide Chemical compound C1=CC=C2[N-]C=NC2=C1 KLTWGRFNJPLFDA-UHFFFAOYSA-N 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000005426 pharmaceutical component Substances 0.000 abstract 1
Abstract
การประดิษฐ์ได้ให้สารประกอบของสูตร(I) หรือเกลือที่ยอมรับได้ทางเภสัชกรรมของมัน โดยที่ R1,R2 เเละ R3 เป็นดังที่ได้บรรยายในที่นี้ องค์ประกอบทางเภสัชกรรมของมัน เเละการใช้ของมัน ในการรักษาโรค ภาวะหรือความผิดปกติที่ป่รับเปลี่ยนได้โดยการยับยั้งเอนไซม์อะซีทิล CoA คาร์บอกศิเลสในสัตว์ The invention provided compounds of formula (I), or its pharmacologically acceptable salts, where R1, R2 and R3 are described here. Its pharmaceutical components And the use of it In the treatment of disease Conditions or Abnormalities Changed by Inhibition of the enzyme acetyl, CoA, carboxylase in animals.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH135295A TH135295A (en) | 2014-07-21 |
| TH135295B true TH135295B (en) | 2014-07-21 |
Family
ID=
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