TH135239B - Solid pharmaceutical components containing amlodipine and losartan - Google Patents
Solid pharmaceutical components containing amlodipine and losartanInfo
- Publication number
- TH135239B TH135239B TH1101001236A TH1101001236A TH135239B TH 135239 B TH135239 B TH 135239B TH 1101001236 A TH1101001236 A TH 1101001236A TH 1101001236 A TH1101001236 A TH 1101001236A TH 135239 B TH135239 B TH 135239B
- Authority
- TH
- Thailand
- Prior art keywords
- losartan
- amlodipine
- solid pharmaceutical
- components containing
- pharmaceutical components
- Prior art date
Links
- HTIQEAQVCYTUBX-UHFFFAOYSA-N Amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 title claims abstract 4
- 239000002083 C09CA01 - Losartan Substances 0.000 title claims abstract 4
- KJJZZJSZUJXYEA-UHFFFAOYSA-N Losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 title claims abstract 4
- 229960004773 Losartan Drugs 0.000 title claims abstract 4
- 229960000528 amlodipine Drugs 0.000 title claims abstract 4
- 239000007787 solid Substances 0.000 title claims abstract 3
- 239000005426 pharmaceutical component Substances 0.000 title 1
- 210000004204 Blood Vessels Anatomy 0.000 claims abstract 2
- 229960001681 Croscarmellose Sodium Drugs 0.000 claims abstract 2
- 229920002785 Croscarmellose sodium Polymers 0.000 claims abstract 2
- 239000004480 active ingredient Substances 0.000 claims abstract 2
- 239000003795 chemical substances by application Substances 0.000 claims abstract 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims abstract 2
- 201000010099 disease Diseases 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 2
- 229940079832 sodium starch glycolate Drugs 0.000 claims abstract 2
- 229920003109 sodium starch glycolate Polymers 0.000 claims abstract 2
- 239000008109 sodium starch glycolate Substances 0.000 claims abstract 2
- 229960000913 Crospovidone Drugs 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinylpyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 238000000354 decomposition reaction Methods 0.000 claims 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 1
Abstract
การประดิษฐ์นี้เกี่ยวกับองค์ประกอบทางเภสัชกรรมประเภทของแข็งสำหรับป้องกันหรือ รักษาความผิดปกติของหัวใจร่วมหลอดเลือด ซึ่งประกอบรวมด้วยแอมโลดิพีนและโลซาร์แทนใน ฐานเป็นส่วนผสมออกฤทธิ์, และสารช่วยให้เม็ดยาแตกตัวซึ่งคือของผสมของส่วนประกอบอย่าง น้อยที่สุดสองชนิดซึ่งเลือกได้จากกลุ่มซึ่งประกอบด้วย โซเดียม สทาร์ช ไกลโคเลท, ครอสคาร์เมล โลส โซเดียม, และ ครอสโพวิโคน, ซึ่งแสดงระดับที่สูงและเสถียรของอัตราการละลายของ แอมโลดิพีน และโลซาร์แทน This invention deals with a pharmaceutical solid component for protection or Treat disorders of the heart, joint, blood vessels Which includes amlodipine and losartan in The base is an active ingredient, and the disintegrating agent is a mixture of components like Two minimums, which were selected from the group, consisted of sodium starch glycolate, croscarmellose sodium, and crospovicone, which exhibited a high and stable level of solubility of Amlodipine and Losartan
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH135239B true TH135239B (en) | 2014-07-21 |
| TH135239A TH135239A (en) | 2014-07-21 |
Family
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