TH13398EX - Pharmacy - Google Patents

Abstract

Using the compound of the formula (I) ** chemical formula **, where n is 3 to 8; q is 5 to 11; R1 represents C1-6 Alkyl or C1-6 Alkyl; s is zero, 1 or 2; x instead of oxygen or sulfur; And Ar instead of the selected phenyl. It was obtained by 1-3 substituting groups selected from halo, C1-8 alkyl, C1-8 alkyl, C1-2 alkyl dioxin, trifluor. Romethyl, trifluoroxide, or Ph- (CH2) mY- (CH2) p- group, where ph is an optional substituted phenyl, m and p are independent of 0 to 4 and Y are bonds, O, S or CH = CH, provided that m + p is not greater than 4, or Ar is the selective tricyclic hetero aeryl group **. Chemical formula ** where Y1 is Y (CH2) x where x is 0 or 1 and y is O, S or NR when R is hydrogen or C1-4 alkyl, z is (CH2) r or -CH = CH, r is 0,1 or 2 or Ar is a corresponding hydro-cyclic orbital system, or a salt that is acceptable via Its pharmaceutical In the production of medical supplies for the treatment of conditions When antagonism of the gangcium channel to a new compound of formula (I) was identified, the method for its preparation. It and pharmaceutical mixtures that contain it as well:

Claims (1)

1. Using formula compounds (I) ** Chemical formula ** where n is 3 to 8; q is 5 to 11; R1 represents C1-6 alkyl or C1-6 alkyl; s is zero, 1 or 2; x represents oxygen. Or sulfur; And Ar instead of the selected phenyl. It was obtained by 1-3 substituting groups selected from halo, C1-8 alkyl, C1-8 alkyl, C1-2 alkyl dioxin, trifluor. Romethyl, trifluoroxide, or Ph- (CH2) mY- (CH2) p- group, where ph is an optional substituted phenyl, m and p are independent of 0 to 4 and Y are bonds, O, S or CH = CH, provided m + p is not greater than 4, or