TH13394B - Injectable solution or solution released into a blood vessel - Google Patents
Injectable solution or solution released into a blood vesselInfo
- Publication number
- TH13394B TH13394B TH9501003419A TH9501003419A TH13394B TH 13394 B TH13394 B TH 13394B TH 9501003419 A TH9501003419 A TH 9501003419A TH 9501003419 A TH9501003419 A TH 9501003419A TH 13394 B TH13394 B TH 13394B
- Authority
- TH
- Thailand
- Prior art keywords
- solution
- weight
- flow
- acid
- endoflozacin
- Prior art date
Links
- 210000004204 blood vessel Anatomy 0.000 title claims 4
- 229940102223 injectable solution Drugs 0.000 title 1
- 239000000243 solution Substances 0.000 claims abstract 10
- 239000000203 mixture Substances 0.000 claims abstract 8
- 239000000126 substance Substances 0.000 claims abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000002253 acid Substances 0.000 claims abstract 3
- 238000009472 formulation Methods 0.000 claims abstract 3
- 238000002347 injection Methods 0.000 claims abstract 3
- 239000007924 injection Substances 0.000 claims abstract 3
- 150000007513 acids Chemical class 0.000 claims abstract 2
- 239000008280 blood Substances 0.000 claims abstract 2
- 210000004369 blood Anatomy 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 235000012208 gluconic acid Nutrition 0.000 claims 1
- 239000000174 gluconic acid Substances 0.000 claims 1
- 229940097043 glucuronic acid Drugs 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- SPFYMRJSYKOXGV-UHFFFAOYSA-N Baytril Chemical compound C1CN(CC)CCN1C(C(=C1)F)=CC2=C1C(=O)C(C(O)=O)=CN2C1CC1 SPFYMRJSYKOXGV-UHFFFAOYSA-N 0.000 abstract 2
- 229960000740 enrofloxacin Drugs 0.000 abstract 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 1
- 229960001138 acetylsalicylic acid Drugs 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000003708 ampul Substances 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับสารละลายฉีดและสารละลายที่ปล่อยให้ไหลเข้าหลอด เลือดของสารผสมต่อไป a) 0.1 ถึง 20% โดยน้ำหนักของเอ็นโรฟลอซาซิน, บนพื้นฐานลง น้ำหนักสารละลายทั้งหมด, ในรูปของเกลือของมันกับกรดไฮดรอกซิ คาร์บอกลิค หรือกรดอมิโน หรือของผสมของสาร เหล่านี้ b) กรดโพลีไฮดรอกซิคาร์บอกซีลิค, กรดอมิโน หรือของผสมของ สารเหล่านี้ใน 0.1 ถึง 5 โมลาร์ที่มากเกินพอ, บนพื้นฐานของ เอ็นโรฟลอซาซิน c) อย่างเลือกได้ 0.1 ถึง 30% โดยน้ำหนักของสาร ช่วยฟอร์มูเลชั่น, บนพื้นฐานของน้ำหนัก สารละลายทั้งหมด d) น้ำให้ถึง 100% โดยน้ำหนัก สิทธิบัตรยา This invention involves the injection solution and the let-through solution into the ampoule. the blood of the next mixture a) 0.1 to 20% by weight of enrofloxacin, on a weighted basis of the total solution, in the form of its salts with hydroxycarboxylic acids or acetylsalicylic acid. aminos or mixtures of these; b) polyhydroxycarboxylic acids, amino acids or mixtures of These substances in 0.1 to 5 molar excess, based on enrofloxacin c) selectively 0.1 to 30% by weight of substance. Helps formulation, on a weight-based basis. Total solution d) Water to 100% by weight. Drug patent.
Claims (4)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH19908A TH19908A (en) | 1996-08-07 |
| TH13394B true TH13394B (en) | 2002-08-30 |
Family
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