TH133904B - Non-invasive drug form that releases aromatase inhibitors and gestagen to treat endometriosis. - Google Patents
Non-invasive drug form that releases aromatase inhibitors and gestagen to treat endometriosis.Info
- Publication number
- TH133904B TH133904B TH1201005210A TH1201005210A TH133904B TH 133904 B TH133904 B TH 133904B TH 1201005210 A TH1201005210 A TH 1201005210A TH 1201005210 A TH1201005210 A TH 1201005210A TH 133904 B TH133904 B TH 133904B
- Authority
- TH
- Thailand
- Prior art keywords
- gestagen
- aromatase inhibitors
- releases
- ovarian
- drug form
- Prior art date
Links
- 229940046844 Aromatase inhibitors Drugs 0.000 title claims abstract 4
- 239000003886 aromatase inhibitor Substances 0.000 title claims abstract 4
- 239000000583 progesterone congener Substances 0.000 title claims abstract 3
- 239000003814 drug Substances 0.000 title abstract 4
- 229940079593 drugs Drugs 0.000 title abstract 4
- 201000009273 endometriosis Diseases 0.000 title abstract 2
- 230000002611 ovarian Effects 0.000 claims abstract 2
- 230000016087 ovulation Effects 0.000 claims abstract 2
- 230000000638 stimulation Effects 0.000 claims abstract 2
- 239000004083 gastrointestinal agent Substances 0.000 claims 1
- 210000003679 Cervix Uteri Anatomy 0.000 abstract 1
- 210000001035 Gastrointestinal Tract Anatomy 0.000 abstract 1
- 102000006771 Gonadotropins Human genes 0.000 abstract 1
- 108010086677 Gonadotropins Proteins 0.000 abstract 1
- 210000003097 Mucus Anatomy 0.000 abstract 1
- 210000001672 Ovary Anatomy 0.000 abstract 1
- 210000004291 Uterus Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 235000013601 eggs Nutrition 0.000 abstract 1
- 239000002622 gonadotropin Substances 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000000287 oocyte Anatomy 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 230000032258 transport Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้สำหรับการรักษาภาวะเยื่อบุมดลูกเจริญผิดที่เกี่ยวข้องกับการนำเสนอรูปแบบ ยา(ระบบนำส่งยา)ที่ไม่ผ่านทางเดินอาหาร เพื่อปลดปล่อยสารยับยั้งอะโรมาเทส (AI)แบบควบคุม ด้วยอัตราการปลดปล่อยต่อวันที่ไม่ชักนำการกระตุ้นรังไข่โดยการป้อนกลับเชิงลบของ pituitary- ovarian-axis (ซึ่งจะทำให้เกิดการหลั่งโกนาโดโทรปินและการกระตุ้นการเจริญเติบโตของฟอลลิเคิล ของรังไข่)และเจสตาเจนด้วยอัตราการปลดปล่อยที่ต่ำกว่าขนาดยาที่ยับยั้งการตกไข่ซึ่งทำให้มี ประสิทธิผลด้านการคุ้กำเนิดบนพื้นฐานของผลเฉพาะที่(เช่นการลดปริมาณและการข้นขึ้นของเมือก ที่ปากมดลูกซึ่งจะทำให้อสุจิเดินทางขึ้นไปข้างบนได้น้อยลง, ผลต่อเยื่อบุมดลูกและต่อการเคลื่อนไหว เองของท่ำนำไข่ซึ่งจะไปลดการฝังตัวและการขนส่งไข่) This invention is for the treatment of endometriosis associated with the model presentation. Medicines (drug delivery systems) that do not pass through the digestive tract To release aromatase inhibitors (AI) controlled model With a non-induced daily release rate, ovarian stimulation by negative pituitary- ovarian-axis feedback (which leads to gonadotropin secretion and follicle-stimulating growth). Ovaries) and gestagen, with a release rate lower than that of ovulation-inhibiting drug, resulting in The effectiveness of the origin based on local effects (e.g. reducing the volume and thickening of mucus, In the cervix, which allows the sperm to travel less upward, affecting the lining of the uterus and on its movement The oocyte itself, which reduces implantation and egg transport)
Claims (1)
Publications (2)
Publication Number | Publication Date |
---|---|
TH133904B true TH133904B (en) | 2014-05-26 |
TH133904A TH133904A (en) | 2014-05-26 |
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