TH132228B - Monoclonal antibodies (Monoclonal anitbody) - Google Patents
Monoclonal antibodies (Monoclonal anitbody)Info
- Publication number
- TH132228B TH132228B TH1201001370A TH1201001370A TH132228B TH 132228 B TH132228 B TH 132228B TH 1201001370 A TH1201001370 A TH 1201001370A TH 1201001370 A TH1201001370 A TH 1201001370A TH 132228 B TH132228 B TH 132228B
- Authority
- TH
- Thailand
- Prior art keywords
- fibrinogen
- domain
- fibrin
- antibodies
- monoclonal
- Prior art date
Links
- 229960000070 antineoplastic Monoclonal antibodies Drugs 0.000 title 1
- 229960000060 monoclonal antibodies Drugs 0.000 title 1
- 102000005614 monoclonal antibodies Human genes 0.000 title 1
- 108010045030 monoclonal antibodies Proteins 0.000 title 1
- 102000004965 antibodies Human genes 0.000 claims abstract 10
- 108090001123 antibodies Proteins 0.000 claims abstract 10
- 229940012952 Fibrinogen Drugs 0.000 claims abstract 9
- 102000008946 Fibrinogen Human genes 0.000 claims abstract 9
- 108010049003 Fibrinogen Proteins 0.000 claims abstract 9
- 229940019698 Fibrinogen containing hemostatics Drugs 0.000 claims abstract 9
- 229950003499 FIBRIN Drugs 0.000 claims abstract 7
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims abstract 7
- 102000009123 Fibrin Human genes 0.000 claims abstract 7
- 108010073385 Fibrin Proteins 0.000 claims abstract 7
- 210000000274 Microglia Anatomy 0.000 claims abstract 2
- 210000003008 brain-resident macrophage Anatomy 0.000 claims abstract 2
- 101700063896 mac-1 Proteins 0.000 claims abstract 2
- 201000010874 syndrome Diseases 0.000 claims abstract 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 208000008581 Brain Disease Diseases 0.000 claims 1
- 206010014623 Encephalopathy Diseases 0.000 claims 1
- 206010014625 Encephalopathy Diseases 0.000 claims 1
- 230000000881 depressing Effects 0.000 claims 1
- 210000004556 Brain Anatomy 0.000 abstract 1
- 210000000278 Spinal Cord Anatomy 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000004027 cells Anatomy 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 238000005755 formation reaction Methods 0.000 abstract 1
Abstract
การประดิษฐ์ปัจจุบันนี้ได้จัดให้มีแอนติบอดีแยกเดี่ยว(isolatedantibody)ที่เข้าจับไฟบริน หรือไฟบริโนเจนYCโดเมนในแง่มุมต่างๆแอนติบอดีไปยับยั้งการยึดเกาะไมโครเกลียกับ ไฟบรินหรือไฟบริโนเจนyCโดเมน,ยับยั้งMac-1ที่เข้าจับไฟบรินหรือไฟบริโนเจนyCโดเมน และ/หรือกดกลุ่มอาการทางคลินิกของโรคสมองและไขสันหลังอักเสบเหตุภูมิต้านตนเองในการ ทดลอง(EAE)วิธีการต่างๆของการใช้แอนติบอดี,องค์ประกอบทางเภสัชกรรม,ชุดสำเร็จรูป, เวคเตอร์,เซลล์ที่ประกอบด้วยเวคเตอร์และวิธีการสร้างแอนติบอดีได้ถูกจัดให้มีขึ้น (กราฟ) The present invention provides for a single antibody (isolatedantibody) that binds fibrin. Or fibrinogen YC domain, in various aspects, antibodies to inhibit microglia adhesion to Fibrinogen or fibrinogen yC domain, inhibits Mac-1 binding fibrin or fibrinogen yC domain. And / or suppress clinical syndromes of the brain and spinal cord, autoimmune causes of Experimental (EAE) methods of antibody utilization, pharmaceutical constituents, prefabricated kits, vectors, vector-containing cells and antibody formation methods were provided (graph).
Claims (3)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH132228A TH132228A (en) | 2014-04-01 |
| TH132228B true TH132228B (en) | 2014-04-01 |
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