TH132080A - Emido-Tropane Derivatives (Amido-tropane derivatives) - Google Patents

Abstract

DC60 (17/12/55). This invention. It is related to compounds of the general formula I (chemical formula) I, where R1, R2 and R3 are independent of each other, each of them is hydrogen, low-molecular-mass alkyl, mass alkoxy. Low molecule, cycloalkyl, molecular mass alkyl Low that is replaced by halogen or low molecular mass S-alkyl; Or with the addition of a pharmaceutical acidic acid salt, with a resamic mixture, or with its corresponding enanthiomer and / or its optical isomer. It has been found surprisingly A compound of the general formula I is a good inhibitor of the glycine 1 (GlyT-1) transporter, and that it has a good selective state, also a glycine 2 (GlyT-2) transporter inhibitor may be used. In the treatment of neurological and psychiatric disorders. This invention It is related to compounds of the general formula I (chemical formula) I, where R1, R2 and R3 are independent of each other, each of them is hydrogen, low-molecular-mass alkyl, mass alkoxy. Low molecule, cycloalkyl, molecular mass alkyl Low that is replaced by halogen or low molecular mass S-alkyl; Or salts from the addition of a pharmaceutical acid, a resimic mixture, or Its corresponding enanthiomers and / or its optical isomers. It has been found surprisingly Compounds of the general formula I are good inhibitors of glycine transporters. 1 (GlyT-1), and that it would have a good selective state, also a glycine-2 (GlyT-2) inhibitor compound may be used in the treatment of neurological and psychiatric disorders. . Drug patent

Claims (1)

: DC60 (17/12/55) This invention It is related to compounds of the general formula I (chemical formula) I, where R1, R2 and R3 are independent of each other, each of them is hydrogen, low-molecular-mass alkyl, mass alkoxy. Low molecule, cycloalkyl, molecular mass alkyl Low that is replaced by halogen or low molecular mass S-alkyl; Or with the addition of a pharmaceutical acidic acid salt, with a resamic mixture, or with its corresponding enanthiomer and / or its optical isomer. It has been found surprisingly A compound of the general formula I is a good inhibitor of the glycine 1 (GlyT-1) transporter, and that it has a good selective state, also a glycine 2 (GlyT-2) transporter inhibitor may be used. In the treatment of neurological and psychiatric disorders. This invention It is related to compounds of the general formula I (chemical formula) I, where R1, R2 and R3 are independent of each other, each of them is hydrogen, low-molecular-mass alkyl, mass alkoxy. Low molecule, cycloalkyl, molecular mass alkyl Low that is replaced by halogen or low molecular mass S-alkyl; Or salts from the addition of a pharmaceutical acid, a resimic mixture, or Its corresponding enanthiomers and / or their optical isomers. It has been found surprisingly Compounds of the general formula I are good inhibitors of glycine transporters. 1 (GlyT-1), and that it would have a good selective state, also a glycine-2 (GlyT-2) inhibitor compound may be used in the treatment of neurological and psychiatric disorders. Claims (Item one) which will appear on the advertisement page: 1. Compounds of the general formula (chemical formula) I, where R1, R2 and R3 are independent of each other, they are hydrogen, low-molecular-mass alkyl, low-molecular alkoxy. , Cycloalkyl (cycloalkyl), molecular mass alkyl Low that is replaced by halogen or low molecular mass S-alkyl; Tag: drug patent