TH131135B - Aryl- and hetero-aryl carbonyl derivatives of hexahydroindopyridine. And octahydrophobic benzoquinoline - Google Patents
Aryl- and hetero-aryl carbonyl derivatives of hexahydroindopyridine. And octahydrophobic benzoquinolineInfo
- Publication number
- TH131135B TH131135B TH1201002093A TH1201002093A TH131135B TH 131135 B TH131135 B TH 131135B TH 1201002093 A TH1201002093 A TH 1201002093A TH 1201002093 A TH1201002093 A TH 1201002093A TH 131135 B TH131135 B TH 131135B
- Authority
- TH
- Thailand
- Prior art keywords
- aryl
- octahydrophobic
- hexahydroindopyridine
- benzoquinoline
- hetero
- Prior art date
Links
- 125000005129 aryl carbonyl group Chemical group 0.000 title 1
- WZJYKHNJTSNBHV-UHFFFAOYSA-N benzo[h]quinoline Chemical compound C1=CN=C2C3=CC=CC=C3C=CC2=C1 WZJYKHNJTSNBHV-UHFFFAOYSA-N 0.000 title 1
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 239000000126 substance Substances 0.000 claims abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- -1 furanil Chemical group 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract 2
- 210000004369 Blood Anatomy 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 102000004316 Oxidoreductases Human genes 0.000 abstract 1
- 108090000854 Oxidoreductases Proteins 0.000 abstract 1
- 208000001072 Type 2 Diabetes Mellitus Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 230000002503 metabolic Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับสารประกอบดังถูกนิยามด้วยสูตร I (สูตรเคมี) ที่ซึ่ง R1,R2,R3,R4 และ m ถูกนิยามไว้ดังในข้อถือสิทธิ 1 ซึ่งมีค่าในการออกฤทธิ์ทาง เภสัชวิทยา โดยเฉพาะอย่างยิ่ง สารประกอบเป็นสารยับยั้งเอนไซม์ 11เบตา-ไฮดรอกซีสเตียรอยด์ดีไฮโดร จีเนส(HSD) 1 ดังนั้น จึงเหมาะสมสำหรับการรักษาและการป้องกันโรคต่างๆ ซึ่งมีผลได้โดยการ ยับยั้งเอนไซม์นี้ เช่น ความผิดปกติในการสร้างและทำลาย (metabolic)โดยเฉพาะเบาหวานชนิด 2, โรคอ้วน, และการที่เลือดมีไขมันผิดปกติ This invention relates to a compound defined with the formula I (chemical formula) where R1, R2, R3, R4 and m are defined as in claim 1, which has a particular pharmacological action value. The compound is an enzyme inhibitor. 11 Beta-hydroxyst steroid dehydrogenase (HSD) 1, therefore suitable for treatment and prevention of many diseases. Which is effective by Inhibit this enzyme, such as production and destruction disorders. (metabolic), especially type 2 diabetes, obesity, and abnormal blood fat.
Claims (1)
Publications (2)
Publication Number | Publication Date |
---|---|
TH131135B true TH131135B (en) | 2014-01-24 |
TH131135A TH131135A (en) | 2014-01-24 |
Family
ID=
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