TH128992A - Preparation Of Nalmefene Hydrochloride From Naltrexone - Google Patents
Preparation Of Nalmefene Hydrochloride From NaltrexoneInfo
- Publication number
- TH128992A TH128992A TH1101003269A TH1101003269A TH128992A TH 128992 A TH128992 A TH 128992A TH 1101003269 A TH1101003269 A TH 1101003269A TH 1101003269 A TH1101003269 A TH 1101003269A TH 128992 A TH128992 A TH 128992A
- Authority
- TH
- Thailand
- Prior art keywords
- nalmefene hydrochloride
- nalmefene
- naltrexone
- salt
- try
- Prior art date
Links
- 229960000677 Nalmefene hydrochloride Drugs 0.000 title claims abstract 11
- GYWMRGWFQPSQLK-OPHZJPRHSA-N (4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-7-methylidene-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol;hydron;chloride Chemical compound Cl.N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 GYWMRGWFQPSQLK-OPHZJPRHSA-N 0.000 title claims abstract 9
- 229960003086 Naltrexone Drugs 0.000 title claims abstract 4
- DQCKKXVULJGBQN-XFWGSAIBSA-N Naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 title claims abstract 4
- -1 salt nalmefene hydrochloride Chemical class 0.000 claims abstract 4
- 239000011780 sodium chloride Substances 0.000 claims abstract 4
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drugs Drugs 0.000 claims abstract 2
- JWUJQDFVADABEY-UHFFFAOYSA-N 2-Methyltetrahydrofuran Chemical compound CC1CCCO1 JWUJQDFVADABEY-UHFFFAOYSA-N 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- WJBLNOPPDWQMCH-MBPVOVBZSA-N Nalmefene Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 WJBLNOPPDWQMCH-MBPVOVBZSA-N 0.000 claims 1
- 238000007239 Wittig reaction Methods 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000005755 formation reaction Methods 0.000 claims 1
- 229960005297 nalmefene Drugs 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
Abstract
DC60 (23/11/54) วิธีการสำหรับการผลิตนาลเมฟีน ไฮโดรคลอไรด์ (nalmefene hydrochloride) จากนาล เทรกโซน (naltrexone) ซึ่งวิธีการจะถูกปรับให้เข้ากันเป็นอย่างดี โดยเฉพาะสำหรับการประยุกต์ใช้ ในอุตสาหกรรมขนาดใหญ่ และได้มีการค้นพบให้มีประสิทธิภาพ เพื่อให้ผลผลิตได้สูง และเพื่อ พยายามให้เกลือนาลเมฟีน ไฮโดรคลอไรด์ (nalmefene hydrochloride salt) มีความบริสุทธิ์สูง วิธีการสำหรับการผลิตนัลเมฟีน ไฮโดรคลอไรด์(nalmefene hydrochloride)จากนาล เทรกโซน(natrexone)ซึ่งวิธีการจะถูกปรับให้เข้ากันเป็นอย่างดี โดยเฉพาะสำหรับการประยุกต์ใช้ ในอุตสาหกรรมขนาดใหญ่ และได้มีการค้นพบให้มีประสิทธิภาพ เพื่อให้ผลผลิตได้สูง และเพื่อ พยายามให้เกลือนาลเมฟีน ไฮโดรคลอไรด์ (nalmefene hydrochloride salt)มีความบริสุทธิ์สูง สิทธิบัตรยา DC60 (23/11/54) A method for the production of nalmefene hydrochloride from naltrexone, in which the method is well adapted. Specifically for the application In a large industry And it has been found to be effective To provide high yields and to try to provide high purity nalmefene hydrochloride salt. Methods for the production of nalmefene Hydrochloride (nalmefene hydrochloride) from nal Trezone (natrexone), in which the method is well adjusted. Specifically for the application In a large industry And it has been found to be effective To achieve high yields and to try to provide salt nalmefene hydrochloride (nalmefene hydrochloride salt), high purity, patent drug
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH128992A true TH128992A (en) | 2013-11-14 |
| TH128992B TH128992B (en) | 2013-11-14 |
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