TH128159B - Stable formulation containing anti-interlukin-6-receptor (IL-6R) antibody. - Google Patents
Stable formulation containing anti-interlukin-6-receptor (IL-6R) antibody.Info
- Publication number
- TH128159B TH128159B TH1201003397A TH1201003397A TH128159B TH 128159 B TH128159 B TH 128159B TH 1201003397 A TH1201003397 A TH 1201003397A TH 1201003397 A TH1201003397 A TH 1201003397A TH 128159 B TH128159 B TH 128159B
- Authority
- TH
- Thailand
- Prior art keywords
- interlukin
- receptor
- pharmaceutical formulation
- formulation containing
- antibody
- Prior art date
Links
- 102000004965 antibodies Human genes 0.000 title claims abstract 5
- 108090001123 antibodies Proteins 0.000 title claims abstract 5
- 238000009472 formulation Methods 0.000 title 1
- 108040006858 interleukin-6 receptor activity proteins Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 6
- 235000000346 sugar Nutrition 0.000 claims abstract 2
- 150000001720 carbohydrates Chemical class 0.000 claims 3
- 235000014633 carbohydrates Nutrition 0.000 claims 3
- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KAZBKCHUSA-N D-Mannitol Natural products OC[C@@H](O)[C@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KAZBKCHUSA-N 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-UUNJERMWSA-N Lactose Natural products O([C@@H]1[C@H](O)[C@H](O)[C@H](O)O[C@@H]1CO)[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1 GUBGYTABKSRVRQ-UUNJERMWSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N Trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 125000000185 sucrose group Chemical group 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N β-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000001195 anabolic Effects 0.000 abstract 1
- 230000003042 antagnostic Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
Abstract
การประดิษฐ์นี้ได้ให้สูตรผสมทางเภสัชกรรมที่ประกอบรวมด้วยแอนตอบอดีของมนุษย์ที่ จับเกาะอย่างจำเพาะกับตัวรับอินเตอร์ลูคิน-6 ของมนุษย์ (hIL-6R) เพิ่มเติมจากแอนติ-hIL-6R แอนติบอดีสูตรผสมอาจมีกรดอะมิโนอย่างน้อยหนึ่งชนิด,น้ำตาลอย่างน้อยหนึ่งชนิด,และ/หรือ สารลดแรงตึงผิวที่ไม่เป็นอิออนิกอย่างน้อยหนึ่งชนิดสูตรผสมทางเภสัชกรรมของการประดิษฐ์นี้ แสดงระดับเสถียรภาพของแอนติบอดีที่สูงหลังการเก็บรักษาเป็นเวลาหลายเดือน The invention provides a pharmaceutical formulation containing human anabolic antagonists. Specific binding to the human interlukin-6 receptor (hIL-6R) in addition to the antihil-6R. Formulated antibodies may contain at least one amino acid, at least one sugar, and / or At least one non-ionic surfactant, the pharmaceutical formulation of this invention. Shows high antibody stability levels after several months of storage.
Claims (4)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH128159A TH128159A (en) | 2013-10-15 |
| TH128159B true TH128159B (en) | 2013-10-15 |
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