TH128143A - JAK2 inhibitors and their use for the treatment of myelopropylife and cancer. - Google Patents
JAK2 inhibitors and their use for the treatment of myelopropylife and cancer.Info
- Publication number
- TH128143A TH128143A TH1201000917A TH1201000917A TH128143A TH 128143 A TH128143 A TH 128143A TH 1201000917 A TH1201000917 A TH 1201000917A TH 1201000917 A TH1201000917 A TH 1201000917A TH 128143 A TH128143 A TH 128143A
- Authority
- TH
- Thailand
- Prior art keywords
- formula
- cancer
- treatment
- jak2
- compound
- Prior art date
Links
- 102100019516 JAK2 Human genes 0.000 title claims abstract 5
- 101700016050 JAK2 Proteins 0.000 title claims abstract 5
- 201000011510 cancer Diseases 0.000 title claims abstract 5
- 239000003112 inhibitor Substances 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 5
- XUIIKFGFIJCVMT-LBPRGKRZSA-N L-thyroxine zwitterion Chemical compound IC1=CC(C[C@H]([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-LBPRGKRZSA-N 0.000 claims abstract 4
- 102000030951 Phosphotransferases Human genes 0.000 claims abstract 4
- 108091000081 Phosphotransferases Proteins 0.000 claims abstract 4
- 229940034208 Thyroxine Drugs 0.000 claims abstract 4
- 230000001028 anti-proliferant Effects 0.000 claims abstract 4
- 239000003795 chemical substances by application Substances 0.000 claims abstract 4
- 230000000694 effects Effects 0.000 claims abstract 4
- 229950008325 levothyroxine Drugs 0.000 claims abstract 4
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 239000011780 sodium chloride Substances 0.000 claims abstract 4
- 239000000126 substance Substances 0.000 claims abstract 4
- 239000003814 drug Substances 0.000 claims abstract 3
- 229940079593 drugs Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract 1
Abstract
DC60 (24/05/55) การประดิษฐ์นี้ให้สารประกอบของสูตร I (สูตรเคมี) (I) และเกลือของมันที่เป็นที่ยอมรับเชิงเภสัชกรรม สารประกอบสูตร I ยับยั้งไทรอซีนไคเนสแอคติวิตี ของ JAK2, ดังนั้น ทำให้มันเป็นประโยชน์เป็นสารต่อต้านการเพิ่มจำนวนสำหรับการบำบัดมะเร็ง และโรคอื่น ๆ การประดิษฐ์นี้ให้สารประกอบของสูตร I (สูตรเคมี) (I) และเกลือของมันที่เป็นที่ยอมรับเชิงเภสัชกรรม สารประกอบสูตร I ยับยั้งไทรอซีนไคเนสแอคติวิตี ของ JAK2, ดังนั้น ทำให้มันเป็นประโยชน์เป็นสารต่อต้านการเพิ่มจำนวนสำหรับการบำบัดมะเร็ง และโรคอื่น ๆ สิทธิบัตรยา DC60 (24/05/55) This invention provides a compound of formula I (chemical formula) (I) and its salts that are pharmacologically acceptable. Formula I inhibits the thyroxine kinase activity of JAK2, thus making it useful as an anti-proliferation agent for the treatment of cancer and other ailments.This invention provides a compound of Formula I (chemical formula) (I). And its salts that are acceptable for pharmaceuticals Compound Formula I inhibits the thyroxine kinase activity of JAK2, thus making it useful as an anti-proliferation agent for the treatment of cancer and other diseases.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH128143A true TH128143A (en) | 2013-10-15 |
| TH128143B TH128143B (en) | 2013-10-15 |
Family
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