TH127131B - The process of preparing the photoreactive compound using Transfused hydrogenation - Google Patents
The process of preparing the photoreactive compound using Transfused hydrogenationInfo
- Publication number
- TH127131B TH127131B TH901005821A TH0901005821A TH127131B TH 127131 B TH127131 B TH 127131B TH 901005821 A TH901005821 A TH 901005821A TH 0901005821 A TH0901005821 A TH 0901005821A TH 127131 B TH127131 B TH 127131B
- Authority
- TH
- Thailand
- Prior art keywords
- hydrogenation
- preparation
- transfused
- preparing
- photoreactive compound
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 5
- 150000001875 compounds Chemical class 0.000 title claims abstract 3
- 238000005984 hydrogenation reaction Methods 0.000 title 1
- 238000010531 catalytic reduction reaction Methods 0.000 claims abstract 2
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- LFVPBERIVUNMGV-UHFFFAOYSA-N fasudil hydrochloride Chemical compound Cl.C=1C=CC2=CN=CC=C2C=1S(=O)(=O)N1CCCNCC1 LFVPBERIVUNMGV-UHFFFAOYSA-N 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- GQZXRLWUYONVCP-QMMMGPOBSA-N 3-[(1s)-1-(dimethylamino)ethyl]phenol Chemical compound CN(C)[C@@H](C)C1=CC=CC(O)=C1 GQZXRLWUYONVCP-QMMMGPOBSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 238000009901 transfer hydrogenation reaction Methods 0.000 abstract 1
Abstract
การประดิษฐ์นี้ได้ให้กระบวนการแบบมีการเร่งปฏิกิริยาสำหรับการเตรียมสารประกอบ ที่มีความว่องไวต่อปฏิกิริยาทางแสง และการแปลงผันหลังจากนั้นไปเป็นตัวยาที่ต้องการ โดยเฉพาะกระบวนการนี้สัมพันธ์กับการเตรียม(S)-3-(1-ไดเมททิลามิโน-เอททิล)-ฟีนอล โดยใช้การรีดักชันแบบมีการเร่งปฏิกิริยาชนิดไม่สมมาตรและการไฮโดรจีเนชันแบบถ่ายเท ทำให้ ได้เส้นทางที่ปรับปรุงเพื่อการเตรียมตัวยา เช่น ไรวาสทิกมีนและไรวาสทิกมีนไฮโดรเจนทาร์เทรต This invention provides a catalytic process for the preparation of compounds. That are sensitive to light reactions And conversion after that to the desired drug Specifically, this process is related to the preparation of (S) -3- (1-dimethylamino-ethyl) -phenol. By using asymmetric catalytic reduction and transfer hydrogenation, improved pathways for drug preparation such as rivastigamine and rivastigamine hydrogen tartare were obtained. Square
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH127131B true TH127131B (en) | 2013-09-19 |
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