TH124200A - Interaction inhibitors between MDM2 and P53. - Google Patents
Interaction inhibitors between MDM2 and P53.Info
- Publication number
- TH124200A TH124200A TH501004416A TH0501004416A TH124200A TH 124200 A TH124200 A TH 124200A TH 501004416 A TH501004416 A TH 501004416A TH 0501004416 A TH0501004416 A TH 0501004416A TH 124200 A TH124200 A TH 124200A
- Authority
- TH
- Thailand
- Prior art keywords
- formula
- mdm2
- protein
- compounds
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title claims abstract 3
- 230000002401 inhibitory effect Effects 0.000 title claims abstract 3
- 102100019155 MDM2 Human genes 0.000 title 1
- 101700032565 MDM2 Proteins 0.000 title 1
- 230000003993 interaction Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 4
- 102000004169 proteins and genes Human genes 0.000 claims abstract 3
- 108090000623 proteins and genes Proteins 0.000 claims abstract 3
- 210000000349 Chromosomes Anatomy 0.000 claims abstract 2
- 230000001413 cellular Effects 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drugs Drugs 0.000 claims abstract 2
- 239000005426 pharmaceutical component Substances 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- 230000001629 suppression Effects 0.000 claims 1
- 102000001742 Tumor Suppressor Proteins Human genes 0.000 abstract 1
- 108010040002 Tumor Suppressor Proteins Proteins 0.000 abstract 1
- 239000000225 tumor suppressor protein Substances 0.000 abstract 1
Abstract
DC60 (21/03/55) การประดิษฐ์นี้ให้สารประกอบของสูตร (I), การใช้สารเหล่านี้เป็นสารยับยั้งอันตรกิริยา p53 (protein 53 KDa, tumour suppressor protein) - MDM2 (murine double minute chromosome protien 2, cellular proto-oncogene) และเช่นเดียวกันองค์ประกอบทางเภสัชกรรม ซึ่งประกอบรวม ด้วยสารประกอบดังกล่าวของสูตร (I) (สูตรเคมี) (I) ซึ่ง n, m, p, s, t, R1, R2, R3, R4, R5, R6, R7, X, Y, Q และ Z ได้มีการกำหนดความหมายไว้ สิทธิบัตรยา DC60 (21/03/55) This invention provides compounds of formula (I), the use of them as inhibitors of p53 (protein 53 KDa, tumor suppressor protein) - MDM2 (murine double minute chromosome protien 2, cellular proto-oncogene) and, likewise, pharmaceutical components Included With such compounds of formula (I) (chemical formula) (I), where n, m, p, s, t, R1, R2, R3, R4, R5, R6, R7, X, Y, Q and Z are Prescribed drug patents
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH124200A true TH124200A (en) | 2013-05-31 |
| TH124200B TH124200B (en) | 2013-05-31 |
Family
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