TH124154B - The process of preparing Itraconazole is an amorphous solid that dissolves rapidly in the digestive tract. By evaporation under vacuum At low temperatures - Google Patents

Info

Publication number

TH124154B

TH124154B TH1001000227A TH1001000227A TH124154B TH 124154 B TH124154 B TH 124154B TH 1001000227 A TH1001000227 A TH 1001000227A TH 1001000227 A TH1001000227 A TH 1001000227A TH 124154 B TH124154 B TH 124154B

Authority

TH

Thailand

Prior art keywords

under vacuum

low temperatures

digestive tract

amorphous solid

evaporation under

Prior art date

2010-02-15

Links

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• VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 title 1
• 230000008020 evaporation Effects 0.000 title 1
• 238000001704 evaporation Methods 0.000 title 1
• 210000001035 gastrointestinal tract Anatomy 0.000 title 1
• 229960004130 itraconazole Drugs 0.000 title 1
• 238000000034 method Methods 0.000 title 1
• 239000007787 solid Substances 0.000 title 1