TH123656B - IAP inhibitors - Google Patents
IAP inhibitorsInfo
- Publication number
- TH123656B TH123656B TH801002156A TH0801002156A TH123656B TH 123656 B TH123656 B TH 123656B TH 801002156 A TH801002156 A TH 801002156A TH 0801002156 A TH0801002156 A TH 0801002156A TH 123656 B TH123656 B TH 123656B
- Authority
- TH
- Thailand
- Prior art keywords
- alkyl
- iap inhibitors
- compounds
- heterocyclic
- formula
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- -1 Mecapto Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000005343 heterocyclic alkyl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000022534 cell killing Effects 0.000 abstract 1
- 230000009089 cytolysis Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000017074 necrotic cell death Effects 0.000 abstract 1
Abstract
การประดิษฐ์ได้จัดให้มีตัวยับยั้งชนิดใหม่ของ LAP ที่เป็นประโยชน์ในฐานะสารรักษา สำหรับการบำบัดเนื้อร้ายโดยสารประกอบที่มีสูตรทั่วไป U1-M-U2 โดยที่ M คือหมู่เชื่อมต่อที่เชื่อมกันแบบโควาเลนท์ R1, R2, R3, R4 หรือ R5 ของหมู่ U1 กับ R2, R3, R4 หรือ R5 ของ U2; U1 และ U2 มีสูตรทั่วไป (I) (สูตรเคมี) I และ G, X1, X2, R2, R3, R3', R4, R4' และ R5 เป็นดังที่ถูกบรรยายไว้ในที่นี้ The invention provides a useful novel inhibitor of LAP as a therapeutic agent. For the necrosis treatment of compounds with the general formula U1-M-U2, where M is a covalent linkage group R1, R2, R3, R4 or R5 of the U1 and R2, R3, R4 or R5 groups. Of U2; U1 and U2 have general formulas (I) (chemical formulas), I and G, X1, X2, R2, R3, R3 ', R4, R4', and R5 are described here.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH123656B true TH123656B (en) | 2013-05-23 |
| TH123656A TH123656A (en) | 2013-05-23 |
Family
ID=
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