TH115252B - Process for preparing JAK inhibitors and related intermediate compounds. - Google Patents
Process for preparing JAK inhibitors and related intermediate compounds.Info
- Publication number
- TH115252B TH115252B TH1101001161A TH1101001161A TH115252B TH 115252 B TH115252 B TH 115252B TH 1101001161 A TH1101001161 A TH 1101001161A TH 1101001161 A TH1101001161 A TH 1101001161A TH 115252 B TH115252 B TH 115252B
- Authority
- TH
- Thailand
- Prior art keywords
- pyrimidines
- intermediate compounds
- formula
- jak inhibitors
- related intermediate
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000126 substance Substances 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 claims 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 230000003197 catalytic Effects 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 claims 1
- SCFUWKDVGXGFJC-UHFFFAOYSA-N 2-(1H-pyrazol-5-yl)-7H-pyrrolo[2,3-d]pyrimidine Chemical class N1C2=NC=CC2=CN=C1C=1C=CNN=1 SCFUWKDVGXGFJC-UHFFFAOYSA-N 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N 289-95-2 Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 102000030951 Phosphotransferases Human genes 0.000 abstract 1
- 108091000081 Phosphotransferases Proteins 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 210000000278 Spinal Cord Anatomy 0.000 abstract 1
- 200000000018 inflammatory disease Diseases 0.000 abstract 1
- -1 pyrazyl pyrimidines Chemical class 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับกรรมวิธีสำหรับการเตรียมไพราโซลิล ไพรโรโล [2,3-d]ไพริมิดีนที่ถูกแทนที่ไครอล (chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines) ของสูตร lll,และสารประกอบตัวของกลางเซ็งสังเคราะห์ที่เกี่ยวข้อง ไพราโซลิลไพรโรโล[2,3-d]ไพริมิดีนที่ ถูกแทนที่ไครอลเป็นประโยชน์ในรูปตัวยับยั้งของเจนัส ไคเนส แฟมิลี่ของโปรตีน ไทโรซีนไคเนส (proteintyrosinekinases) (JAKs) สำหรับการรักษาของโรคที่มีการอักเสบ, ความผิดปกติ ของการเพิ่มจำนวนเซลล์ไขสันหลัง,และโรคอื่นๆ (สูตรเคมี) The invention involved a procedure for the preparation of pyrazyl pyrimidines [2,3-d] pyrazolyl pyrrolo [2,3-d] pyrimidines) of chiral substituted pyrazolyl pyrrolo [2,3-d] pyrimidines. Lll formula, and related synthetic intermediate compounds Pyrazolil prirolo [2,3-d] pyrimidine Cheryl is useful as an inhibitor of the genus kinase family of proteintyrosinekinases (JAKs) for the treatment of inflammatory diseases, disorders of Increase in the number of cells of the spinal cord, and other diseases (chemical formula)
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH115252B true TH115252B (en) | 2012-07-31 |
| TH115252A TH115252A (en) | 2012-07-31 |
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