TH11239B - - Google Patents
Info
- Publication number
- TH11239B TH11239B TH9201001237A TH9201001237A TH11239B TH 11239 B TH11239 B TH 11239B TH 9201001237 A TH9201001237 A TH 9201001237A TH 9201001237 A TH9201001237 A TH 9201001237A TH 11239 B TH11239 B TH 11239B
- Authority
- TH
- Thailand
- Prior art keywords
- pharmaceutical
- tramadol
- mixtures
- approximately
- oxicodone
- Prior art date
Links
- 239000000203 mixture Substances 0.000 claims abstract 15
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 claims abstract 6
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims abstract 6
- 229960004380 tramadol Drugs 0.000 claims abstract 6
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 claims abstract 6
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims abstract 5
- 229960004126 codeine Drugs 0.000 claims abstract 3
- PPKXEPBICJTCRU-XMZRARIVSA-N (R,R)-tramadol hydrochloride Chemical compound Cl.COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 PPKXEPBICJTCRU-XMZRARIVSA-N 0.000 claims 3
- 229960003107 tramadol hydrochloride Drugs 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 abstract 2
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 abstract 2
- 229960000240 hydrocodone Drugs 0.000 abstract 2
- 230000000144 pharmacologic effect Effects 0.000 abstract 2
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 abstract 2
- 206010010774 Constipation Diseases 0.000 abstract 1
- 206010011224 Cough Diseases 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 206010059866 Drug resistance Diseases 0.000 abstract 1
- 208000000059 Dyspnea Diseases 0.000 abstract 1
- 206010013975 Dyspnoeas Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 229940127240 opiate Drugs 0.000 abstract 1
- 208000013220 shortness of breath Diseases 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับสารผสมที่ประกอบด้วยสารทรามาดอลและโคเดอีน,ออกซิโคโดน หรือ ไฮโดรโคโดน อย่างใดอย่างหนี่งและการใช้ประโยชน์ของสารเหล่านี้สารผสมเหล่านี้เป็นประโยชน์เชิงเภสัชวิทยาในการบำบัดสภาวะความเจ็บปวดท้องเสียและอาการไอ สารผสมเหล่านี้มีผลข้างเคียงน้อยกว่างเมื่อเปรียบเทียบกับสารผสมที่มีโอปิเอทบริสุทธิ์เป็นพื้นฐาน อย่างเช่น การขาดสติ การดื้อยา ท้องผูกและการหายใจติดขัด นอกจากนั้นเมื่อส่วนผสมต่างๆ นั่นคือ สารทรามาดอลและโคเดอีน,ออกซิโคโดนหรือไฮโดรโคโดนอย่างใดอย่างหนี่ง ของสารผสมเหล่านี้ อยู่ภายในอัตราส่วนบางอัตราส่วน ผลทางเภสัชวิทยาของสารผสมเหล่านี้เป็นผลบวกมาก(เสริมฤทธิ์กัน) สิทธิบัตรยา The invention involved some mixtures containing tramadol and codeine, oxicodone or hydrocodone and their uses. Pharmacological benefits for treating pain, diarrhea and cough conditions. These mixtures have fewer side effects compared to pure opiate-based mixtures, such as lack of consciousness, drug resistance, constipation and shortness of breath. Moreover, when the ingredients are tramadol and codeine, oxicodone or hydrocodone. Of these mixtures Is within some aspect ratio The pharmacological effects of these mixtures are very positive (synergistic).
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH13506A TH13506A (en) | 1993-12-15 |
| TH11239B true TH11239B (en) | 2001-11-12 |
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