TH107947A - Macro cyclic urea derivatives and sulfamides derivatives are chain inhibitors of TAFIa. - Google Patents
Macro cyclic urea derivatives and sulfamides derivatives are chain inhibitors of TAFIa.Info
- Publication number
- TH107947A TH107947A TH901002501A TH0901002501A TH107947A TH 107947 A TH107947 A TH 107947A TH 901002501 A TH901002501 A TH 901002501A TH 0901002501 A TH0901002501 A TH 0901002501A TH 107947 A TH107947 A TH 107947A
- Authority
- TH
- Thailand
- Prior art keywords
- derivatives
- formula
- tafia
- sulfamides
- cyclic urea
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title claims abstract 3
- 230000002401 inhibitory effect Effects 0.000 title claims abstract 3
- NVBFHJWHLNUMCV-UHFFFAOYSA-N Sulfamide Chemical class NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 title 1
- -1 cyclic urea derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 4
- 239000003814 drug Substances 0.000 claims abstract 4
- 229940079593 drugs Drugs 0.000 claims abstract 4
- NKCXQMYPWXSLIZ-PSRDDEIFSA-N (2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[2-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-3-m Chemical class O=C([C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)O)C(C)C)N1CCC[C@H]1C(=O)N[C@@H](CO)C(O)=O NKCXQMYPWXSLIZ-PSRDDEIFSA-N 0.000 claims abstract 2
- 206010009802 Coagulopathy Diseases 0.000 claims abstract 2
- 208000005189 Embolism Diseases 0.000 claims abstract 2
- 208000007536 Thrombosis Diseases 0.000 claims abstract 2
- 230000035602 clotting Effects 0.000 claims abstract 2
- 230000015271 coagulation Effects 0.000 claims abstract 2
- 201000010099 disease Diseases 0.000 claims abstract 2
- 230000002265 prevention Effects 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- 230000002792 vascular Effects 0.000 claims abstract 2
- 239000012528 membrane Substances 0.000 claims 1
- 210000003195 Fascia Anatomy 0.000 abstract 1
Abstract
DC60 (04/08/52) การประดิษฐ์นี้เกี่ยวกับสารประกอบของสูตร I (สูตรเคมี) (I) ซึ่งเป็นสารยับยั้งการละลายตัวของลิ่มเลือดที่สามารถถูกแอคทิเวทได้ด้วยธรอมบินที่ถูกแอคทิเวท สารประกอบของสูตร I เหมาะสมสำหรับผลิตยารักษาโรคสำหรับการป้องกัน, การป้องกันขั้นทุติยภูมิ และการรักษาโรคของความผิดปกติหนึ่งชนิดหรือมากกว่าที่ เกี่ยวข้องกับ การเกิดลิ่มเลือดในหลอด เลือด, ภาวะสิ่งหลุดอุดหลอดเลือด, ภาวะที่สามารถจับเป็นลิ่มมากเกินไป หรือการเปลี่ยนแปลงของ พังผืด สิทธิบัตรยา DC60 (04/08/52) This invention deals with the compound of formula I (chemical formula) (I), a clot-dissolving inhibitor that can be activated with the activated thrombin. magic Formula I compounds are suitable for the production of prophylactic, secondary prevention drugs. And the treatment of one or more disorders that Related to Vascular thrombosis, embolism, excessive clotting Or changes in the fascia drug patent
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH107947B TH107947B (en) | 2011-05-20 |
| TH107947A true TH107947A (en) | 2011-05-20 |
Family
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