TH106619B - Azaspiropperidine derivatives - Google Patents
Azaspiropperidine derivativesInfo
- Publication number
- TH106619B TH106619B TH701006773A TH0701006773A TH106619B TH 106619 B TH106619 B TH 106619B TH 701006773 A TH701006773 A TH 701006773A TH 0701006773 A TH0701006773 A TH 0701006773A TH 106619 B TH106619 B TH 106619B
- Authority
- TH
- Thailand
- Prior art keywords
- azaspiropperidine
- derivatives
- invention involves
- chemical formula
- azaspiropperidin
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 239000000126 substance Substances 0.000 claims abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 206010002855 Anxiety Diseases 0.000 abstract 1
- 206010057666 Anxiety disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000005426 pharmaceutical component Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับอนุพันธ์ใหม่ของ อินดอล-3-อิล-คาร์บอนิล-อะซาสไปโร พิเพอริดิน ซึ่งเป็น VIa รีเซพเตอร์ แอนทาโกนิสต์, การรผลิตของพวกมัน, องค์ประกอบทางเภสัชกรรมที่ มีพวกมัน และการใช้งานพวกมันเป็นเวชภัณฑ์ สารประกอบออกฤทธิ์ตามการประดิษฐ์ครั้งนี้จะมี ประโยชน์ในการป้องกัน และ/หรือ การบำบัดของความวิตกกังวล และความผิดปกติเกี่ยวกับ ภาวะ ซึมเศร้าและโรคอื่น ๆ โดยเฉพาะ, การประดิษฐ์นี้เกี่ยวข้องกับสารประกอบตามสูตรทั่วไป (I) (สูตรเคมี) โดยที่ R1 ถึง R6, U, V, W, X, Y และ Z คือดังที่ถูกนิยามไว้ในรายละเอียด This invention involves a new derivative of Indol-3-il-carbonyl-azaspiropperidin, which is the VIa receptor antagonist, their production, the pharmaceutical component that Have them and use them as medical supplies Active compounds according to the invention will have Anxiety prevention and / or therapy benefit And especially related to depression and other disorders, this invention involves compounds based on the general formula (I) (chemical formula) where R1 to R6, U, V, W, X, Y and Z are as follows. That are defined in detail
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH106619A TH106619A (en) | 2011-03-18 |
| TH106619B true TH106619B (en) | 2011-03-18 |
Family
ID=
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