TH105731B - Thia (Dai) Sol, an antagonist of fast-dissociated dopamine receptors. - Google Patents
Thia (Dai) Sol, an antagonist of fast-dissociated dopamine receptors.Info
- Publication number
- TH105731B TH105731B TH801001987A TH0801001987A TH105731B TH 105731 B TH105731 B TH 105731B TH 801001987 A TH801001987 A TH 801001987A TH 0801001987 A TH0801001987 A TH 0801001987A TH 105731 B TH105731 B TH 105731B
- Authority
- TH
- Thailand
- Prior art keywords
- antagonist
- sol
- fast
- thia
- dai
- Prior art date
Links
- 230000003042 antagnostic Effects 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 102000015554 Dopamine receptor family Human genes 0.000 title 1
- 108050004812 Dopamine receptor family Proteins 0.000 title 1
- 241000534944 Thia Species 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 4
- 239000000126 substance Substances 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N Fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 206010061920 Psychotic disease Diseases 0.000 abstract 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 201000008779 central nervous system disease Diseases 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 abstract 1
- 229960003495 thiamine Drugs 0.000 abstract 1
- 235000019157 thiamine Nutrition 0.000 abstract 1
- 239000011721 thiamine Substances 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับสารอนุพันธ์ [1-(เบนซิล)-พิเพอริดิน-4-อิล]-([1,3,4]ไธอะไดอะ โซล-2-อิล)-เอมีน และ [1-(เบนซิล)-พิเพอริดิน-4-อิล]-(ไธอะโซล-2-อิล)-เอมีน ซึ่งเป็นแอนทาโกนิสท์ ของรีเซพเตอร์โดพามีน 2 ที่แยกตัวออกเร็ว, กระบวนการสำหรับการเตรียมสารประกอบเหล่านี้, องค์ประกอบทางเภสัชกรรม ซึ่งประกอบรวมด้วยกระบวนการสำหรับการเตรียมสารประกอบเหล่านี้ ที่เป็นส่วนผสมออกฤทธิ์ สารประกอบพบว่ามีประโยชน์เป็นยา สำหรับการบำบัดหรือการป้องกัน ความผิดปรกติของระบบประสาทส่วนกลาง, ตัวอย่างเช่น โรคจิตเภท, โดยมีผลในการรักษาโรคจิต โดยไม่มีผลข้างเคียงต่อระบบการเคลื่อนไหวร่างกาย This invention relates to derivatives. [1- (benzyl) -piperidin-4-il] - ([1,3,4] thiamine Sol-2-il) -amine and [1- (benzyl) -piperidin-4-il] - (thiazole-2-il) -amine. Which is an antagonist Of fast-isolated dopamine 2 receptor, process for the preparation of these compounds, pharmaceutical constituents This includes a process for the preparation of these compounds. As an active ingredient The compound was found to be useful as a medicine. For therapy or prevention Central nervous system disorders, for example schizophrenia, with psychotic effects Without any adverse effects on the movement system
Claims (1)
Publications (2)
Publication Number | Publication Date |
---|---|
TH105731B true TH105731B (en) | 2011-01-26 |
TH105731A TH105731A (en) | 2011-01-26 |
Family
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TH105731B (en) | Thia (Dai) Sol, an antagonist of fast-dissociated dopamine receptors. | |
TH105731A (en) | Thia (Dai) Sol, an antagonist of fast-dissociated dopamine receptors. |