TH105555A - N-azabisyclic carboxamide derivatives, preparation and therapeutic use of this substance - Google Patents
N-azabisyclic carboxamide derivatives, preparation and therapeutic use of this substanceInfo
- Publication number
- TH105555A TH105555A TH901000212A TH0901000212A TH105555A TH 105555 A TH105555 A TH 105555A TH 901000212 A TH901000212 A TH 901000212A TH 0901000212 A TH0901000212 A TH 0901000212A TH 105555 A TH105555 A TH 105555A
- Authority
- TH
- Thailand
- Prior art keywords
- independent
- groups
- formula
- nitrogen atoms
- preparation
- Prior art date
Links
- 239000000126 substance Substances 0.000 title claims abstract 3
- 229940053202 antiepileptics Carboxamide derivatives Drugs 0.000 title 1
- 230000001225 therapeutic Effects 0.000 title 1
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims abstract 6
- 125000004432 carbon atoms Chemical group C* 0.000 claims abstract 4
- 239000002253 acid Substances 0.000 claims abstract 2
- 150000007513 acids Chemical class 0.000 claims abstract 2
- 125000003118 aryl group Chemical group 0.000 claims abstract 2
- 125000002619 bicyclic group Chemical group 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drugs Drugs 0.000 claims abstract 2
- 125000004430 oxygen atoms Chemical group O* 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 239000011780 sodium chloride Substances 0.000 claims abstract 2
- 239000012453 solvate Substances 0.000 claims abstract 2
- 125000004434 sulfur atoms Chemical group 0.000 claims abstract 2
- 206010003246 Arthritis Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract 1
Abstract
DC60 (09/04/52) การประดิษฐ์นี้เกี่ยวข้องกับสารประกอบตามสูตรทั่วไป (I) (สูตรเคมี) (I) ซึ่ง X1,X2,X3 และ X4, ซึ่งเป็นอิสระต่อกัน, หมายถึง ไนโตรเจนอะตอม หรือหมู่ C-R1; W หมายถึง ออกซิเจน หรือซัลเฟอร์อะตอม; n เท่ากับ 0, 1, 2 หรือ 3; Y หมายถึง แอริล หรือเฮเทอโรแอริล ซึ่งอาจ เลือกให้ถูกแทนที่ ; A หมายถึง ไบไซคลิกเฮเทอโรแอริลตามสูตร (สูตร) ซึ่ง Z1,Z2,Z3, และ Z4, ซึ่งเป็นอิสระต่อกัน, หมายถึง คาร์บอนอะตอม, ไนโตรเจนอะตอม หรือหมู่ C-R2a; Z5,Z6 และ Z7, ซึ่งเป็นอิสระต่อกัน, หมายถึง ไนโตรเจนอะตอม หรือหมู่ C-R2b;Z8 หมายถึง คาร์บอนอะตอม; ในรูปของเบสหรือของเกลือจากการเติมของกรด, และเช่นเดียวกับในรูปของ ไฮเดรตหรือโซลเวต กรรมวิธีการเตรียมและการใช้ในการรักษาโรค สิทธิบัตรยา DC60 (09/04/52) This invention involves compounds following the general formula (I) (chemical formula) (I), where X1, X2, X3 and X4, independent of each other, refer to nitrogen atoms or C-R1 groups. ; W denotes oxygen or sulfur atoms; n is equal to 0, 1, 2, or 3; Y denotes aryl or heteroeryl, which may be chosen to be replaced; A refers to bicyclic heteroaryyl according to the formula (formula), which Z1, Z2, Z3, and Z4, which are independent of each other, are carbon atoms, nitrogen atoms or C-R2a groups; Z5, Z6 and Z7, independent of each other, refer to nitrogen atoms or C-R2b groups; Z8 represents carbon atoms; In the form of bases or salts from the addition of acids, and as in the form of Hydrate or solvate Methods for preparation and use in the treatment of disease, drug patent.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH105555B TH105555B (en) | 2010-12-30 |
| TH105555A true TH105555A (en) | 2010-12-30 |
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