TH103164B - New imicasolidine derivatives, the preparation of such substances, the use of the above pharmaceutical mixtures containing such substances. - Google Patents
New imicasolidine derivatives, the preparation of such substances, the use of the above pharmaceutical mixtures containing such substances.Info
- Publication number
- TH103164B TH103164B TH201000797A TH0201000797A TH103164B TH 103164 B TH103164 B TH 103164B TH 201000797 A TH201000797 A TH 201000797A TH 0201000797 A TH0201000797 A TH 0201000797A TH 103164 B TH103164 B TH 103164B
- Authority
- TH
- Thailand
- Prior art keywords
- substances
- formula
- cell
- imicasolidine
- derivatives
- Prior art date
Links
- 239000000126 substance Substances 0.000 title claims abstract 5
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 239000011347 resin Substances 0.000 claims 2
- 229920005989 resin Polymers 0.000 claims 2
- -1 (C1-C4) -lcoxi Chemical group 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 238000006073 displacement reaction Methods 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 108010008212 Integrin alpha4beta1 Proteins 0.000 abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 230000008619 cell matrix interaction Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002461 imidazolidines Chemical class 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 230000008611 intercellular interaction Effects 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 230000005945 translocation Effects 0.000 abstract 1
Abstract
อนุพันธ์อิมิดาโซลิดีนชนิดใหม่ตามสูตร I (สูตรเคมี) I โดยที่ A,E,Z,R1,R2,R3,R4 และ R5 มีความหมายดังระบุในข้อถือสิทธิ สารประกอบตามสูตร I เป็น สารออกฤทธิ์ทางเภสัชกรรมที่มีคุณค่าซึ่งเหมาะสมสำหรับอาทิการรักษาโรคซึ่งมีการอักเสบ เช่น ข้อ อักเสบรูมาตอยด์ หรือโรคภูมิแพ้ สารประกอบตามสูตร I เป็นสารยับยั้งการยึดติดและการย้ายที่ของ ลิวโคไซต์ และ/หรือเป็นแอนตะกอนิสต์ของตัวรับการยึดติด VLA-4 ซึ่งจัดอยู่ในกลุ่มของอิทีกริน โดยทั่วไปสารเหล่านี้มีความเหมาะสมสำหรับรักษาโรคซึ่งเกิดจากการยึดติดและ/หรือการย้ายที่ของ ลิวโคไซต์ในขอบข่ายที่ไม่พึงประสงค์ หรือเกี่ยวข้องกับการยึดติดและการย้ายที่ดังกล่าวหรือโดยที่ อันตรกิริยาเซลล์-เซลล์หรือเซลล์-แมทริกซ์ซึ่งมีพื้นฐานบนอันตรกิริยาของตัวรับ VLA-4 กับลิแกนด์มี บทบาท นอกจากนี้ การประดิษฐ์นี้ยังเกี่ยวข้องกับกระบวนการในการเตรียมสารประกอบตามสูตร I, การใช้สารดังกล่าวและเภสัชภัณฑ์ซึ่งมีสารประกอบตามสูตร I A new type of imidazolidine derivative according to formula I (chemical formula) I, where A, E, Z, R1, R2, R3, R4 and R5 have the meanings in the claim. Formula I compound is a valuable pharmaceutical active ingredient suitable for such as the treatment of inflammatory diseases such as rheumatoid arthritis. Or allergies Formula I compounds are inhibitors of leucocyte adhesion and translocation and / or an anhydrous of VLA-4 adhesives, which are classified as etigrin. These substances are generally suitable for the treatment of disease caused by adhesion and / or relocation of The leukocyte in the area that is not desirable. Or relating to the attachment and relocation thereof, or where The cell-cell or cell-matrix interaction, which is based on the interaction of the VLA-4 receptor with the ligand, also plays a role. And pharmaceuticals containing compounds according to formula I.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH103164A TH103164A (en) | 2010-08-11 |
| TH103164B true TH103164B (en) | 2010-08-11 |
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