TH102702B - Process for preparation 2- (2,6-dioxopiperidin-3-il) -1-oxoisoindolines were replaced. - Google Patents
Process for preparation 2- (2,6-dioxopiperidin-3-il) -1-oxoisoindolines were replaced.Info
- Publication number
- TH102702B TH102702B TH501004106A TH0501004106A TH102702B TH 102702 B TH102702 B TH 102702B TH 501004106 A TH501004106 A TH 501004106A TH 0501004106 A TH0501004106 A TH 0501004106A TH 102702 B TH102702 B TH 102702B
- Authority
- TH
- Thailand
- Prior art keywords
- dioxopiperidin
- preparation
- replaced
- oxoisoindolines
- condition
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 230000005856 abnormality Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002476 indolines Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- KNCYXPMJDCCGSJ-UHFFFAOYSA-N piperidine-2,6-dione Chemical compound O=C1CCCC(=O)N1 KNCYXPMJDCCGSJ-UHFFFAOYSA-N 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้เกี่ยวข้องกับกระบวนการใหม่สำหรับการเตรียม 2-(2, 6-ไดออกโซพิเพอริดิน- 3-อิล)-1-ออกโซไอโซอินโดไลน์ถูกแทนที่ซึ่งใช้ประโยชน์สำหรับการป้องกันหรือการรักษาโรคหรือ สภาวะเกี่ยวข้องกับความผิดปกติระดับสูงหรือสภาพในการออกฤทธิ์ของ TNFอัลฟา การประดิษฐ์นี้จัดให้ มีกระบวนการสำหรับการผลิตเชิงการค้าของ 2-(2, 6-ไดออกโซพิเพอริดิน-3-อิล)-1-ออกโซไอโซ อินโดไลน์ถูกแทนที่รวมถึง, แต่ไม่จำกัดต่อ, 3-(4-อะมิโน-1-ออกโซไอโซอินโดลิน-2-อิล) พิเพอริดีน- 2, 6-ไดโอนออกฤทธิ์ในการรักษา The invention involved a new process for the preparation of 2- (2, 6-dioxopiperidin-3-il) -1-oxoiso-indo lines, which were used for the prevention or Cure disease or The condition is associated with a high degree of abnormality or a condition of acting on TNF alpha. There is a process for commercial production of 2- (2, 6-dioxopiperidin-3-il) -1-oxo iso. Indolines were replaced including, but not limited to, 3- (4-amino-1-oxoisoindolin-2-il) piperidine-2, 6-dion. Be effective in treatment
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH102702B true TH102702B (en) | 2010-07-29 |
| TH102702A TH102702A (en) | 2010-07-29 |
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